ID   TMG1_BOVIN              Reviewed;         218 AA.
AC   A7Z070;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Transmembrane gamma-carboxyglutamic acid protein 1;
DE   AltName: Full=Proline-rich gamma-carboxyglutamic acid protein 1;
DE            Short=Proline-rich Gla protein 1;
DE   Flags: Precursor;
GN   Name=PRRG1; Synonyms=TMG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: Gla residues are produced after subsequent post-translational
CC       modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
CC       {ECO:0000250}.
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DR   EMBL; BC153268; AAI53269.1; -; mRNA.
DR   RefSeq; NP_001099110.1; NM_001105640.1.
DR   AlphaFoldDB; A7Z070; -.
DR   SMR; A7Z070; -.
DR   Ensembl; ENSBTAT00000083644; ENSBTAP00000072442; ENSBTAG00000050233.
DR   GeneID; 785916; -.
DR   KEGG; bta:785916; -.
DR   CTD; 5638; -.
DR   VEuPathDB; HostDB:ENSBTAG00000050233; -.
DR   VGNC; VGNC:106878; PRRG1.
DR   GeneTree; ENSGT00940000158538; -.
DR   InParanoid; A7Z070; -.
DR   OMA; WYSFYLA; -.
DR   OrthoDB; 1305760at2759; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000050233; Expressed in spermatocyte and 99 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 4.10.740.10; -; 1.
DR   InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   Pfam; PF00594; Gla; 1.
DR   PRINTS; PR00001; GLABLOOD.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   PROPEP          1..20
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000352667"
FT   CHAIN           21..218
FT                   /note="Transmembrane gamma-carboxyglutamic acid protein 1"
FT                   /id="PRO_0000352668"
FT   TOPO_DOM        21..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..66
FT                   /note="Gla"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   REGION          160..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        37..42
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
SQ   SEQUENCE   218 AA;  25045 MW;  75104E5FF49E73A1 CRC64;
     MGRIFLTGEK ANSVLKRYPR ANGLFEEIRQ GNIERECKEE VCTFEEAREA FENNEKTKEF
     WNTYTKAQQG ESNRGSDWFQ FYLTFPLIFG LFIILLVIFL IWRCFLRNKT RRQTVTESHI
     PFPQHLNIIT TPPPPDEVFD NSGLSPGFLE YVVGRSDSVS TRLSNCDPPP TYEEATGQMN
     LRRSETEPHL DPPPEYEDII NSNSASAIAM VPVATTIK