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TMG1_HUMAN
ID   TMG1_HUMAN              Reviewed;         218 AA.
AC   O14668; B2R7A3; C9JXL7; D3DWA9; Q5JT66;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 171.
DE   RecName: Full=Transmembrane gamma-carboxyglutamic acid protein 1;
DE   AltName: Full=Proline-rich gamma-carboxyglutamic acid protein 1;
DE            Short=Proline-rich Gla protein 1;
DE   Flags: Precursor;
GN   Name=PRRG1; Synonyms=PRGP1, TMG1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=9256434; DOI=10.1073/pnas.94.17.9058;
RA   Kulman J.D., Harris J.E., Haldeman B.A., Davie E.W.;
RT   "Primary structure and tissue distribution of two novel proline-rich gamma-
RT   carboxyglutamic acid proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:9058-9062(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Astrocytoma, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [7]
RP   VARIANT [LARGE SCALE ANALYSIS] ILE-60.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- INTERACTION:
CC       O14668; P07919: UQCRH; NbExp=3; IntAct=EBI-12111452, EBI-1224427;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O14668-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O14668-2; Sequence=VSP_044789, VSP_044790;
CC   -!- TISSUE SPECIFICITY: Highly expressed in the spinal cord.
CC   -!- PTM: Gla residues are produced after subsequent post-translational
CC       modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
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DR   EMBL; AF009242; AAB67070.1; -; mRNA.
DR   EMBL; AK312904; BAG35750.1; -; mRNA.
DR   EMBL; AL356858; CAI40412.1; -; Genomic_DNA.
DR   EMBL; CH471141; EAW59457.1; -; Genomic_DNA.
DR   EMBL; CH471141; EAW59458.1; -; Genomic_DNA.
DR   EMBL; BC041591; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC060833; AAH60833.1; -; mRNA.
DR   CCDS; CCDS14239.1; -. [O14668-1]
DR   CCDS; CCDS55397.1; -. [O14668-2]
DR   RefSeq; NP_000941.1; NM_000950.2. [O14668-1]
DR   RefSeq; NP_001135867.1; NM_001142395.1. [O14668-1]
DR   RefSeq; NP_001166957.1; NM_001173486.1. [O14668-2]
DR   RefSeq; NP_001166960.1; NM_001173489.1. [O14668-1]
DR   RefSeq; NP_001166961.1; NM_001173490.1. [O14668-1]
DR   AlphaFoldDB; O14668; -.
DR   SMR; O14668; -.
DR   BioGRID; 111621; 15.
DR   IntAct; O14668; 2.
DR   STRING; 9606.ENSP00000444278; -.
DR   iPTMnet; O14668; -.
DR   PhosphoSitePlus; O14668; -.
DR   BioMuta; PRRG1; -.
DR   jPOST; O14668; -.
DR   MassIVE; O14668; -.
DR   MaxQB; O14668; -.
DR   PaxDb; O14668; -.
DR   PeptideAtlas; O14668; -.
DR   PRIDE; O14668; -.
DR   ProteomicsDB; 48160; -. [O14668-1]
DR   Antibodypedia; 35083; 117 antibodies from 20 providers.
DR   DNASU; 5638; -.
DR   Ensembl; ENST00000378628.9; ENSP00000367894.4; ENSG00000130962.18. [O14668-1]
DR   Ensembl; ENST00000449135.6; ENSP00000390332.2; ENSG00000130962.18. [O14668-1]
DR   Ensembl; ENST00000463135.1; ENSP00000419999.1; ENSG00000130962.18. [O14668-2]
DR   Ensembl; ENST00000542554.5; ENSP00000444278.1; ENSG00000130962.18. [O14668-1]
DR   Ensembl; ENST00000543642.5; ENSP00000443271.1; ENSG00000130962.18. [O14668-1]
DR   GeneID; 5638; -.
DR   KEGG; hsa:5638; -.
DR   MANE-Select; ENST00000378628.9; ENSP00000367894.4; NM_001142395.2; NP_001135867.1.
DR   UCSC; uc004ddn.4; human. [O14668-1]
DR   CTD; 5638; -.
DR   DisGeNET; 5638; -.
DR   GeneCards; PRRG1; -.
DR   HGNC; HGNC:9469; PRRG1.
DR   HPA; ENSG00000130962; Tissue enhanced (brain).
DR   MIM; 300935; gene.
DR   neXtProt; NX_O14668; -.
DR   OpenTargets; ENSG00000130962; -.
DR   PharmGKB; PA33824; -.
DR   VEuPathDB; HostDB:ENSG00000130962; -.
DR   eggNOG; ENOG502RU75; Eukaryota.
DR   GeneTree; ENSGT00940000158538; -.
DR   HOGENOM; CLU_103591_0_0_1; -.
DR   InParanoid; O14668; -.
DR   OMA; VGHTDIQ; -.
DR   PhylomeDB; O14668; -.
DR   TreeFam; TF332123; -.
DR   PathwayCommons; O14668; -.
DR   SignaLink; O14668; -.
DR   BioGRID-ORCS; 5638; 8 hits in 701 CRISPR screens.
DR   ChiTaRS; PRRG1; human.
DR   GenomeRNAi; 5638; -.
DR   Pharos; O14668; Tbio.
DR   PRO; PR:O14668; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; O14668; protein.
DR   Bgee; ENSG00000130962; Expressed in inferior vagus X ganglion and 187 other tissues.
DR   ExpressionAtlas; O14668; baseline and differential.
DR   Genevisible; O14668; HS.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 4.10.740.10; -; 1.
DR   InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   Pfam; PF00594; Gla; 1.
DR   PRINTS; PR00001; GLABLOOD.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Disulfide bond; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   PROPEP          1..20
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000022541"
FT   CHAIN           21..218
FT                   /note="Transmembrane gamma-carboxyglutamic acid protein 1"
FT                   /id="PRO_0000022542"
FT   TOPO_DOM        21..83
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          21..66
FT                   /note="Gla"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   REGION          161..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        37..42
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   VAR_SEQ         58..82
FT                   /note="KEFWSTYTKAQQGESNRGSDWFQFY -> GLVLLPRLECSCEHGSLQPQLPV
FT                   PK (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_044789"
FT   VAR_SEQ         83..218
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_044790"
FT   VARIANT         60
FT                   /note="F -> I (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036268"
FT   CONFLICT        O14668-2:75
FT                   /note="Q -> R (in Ref. 5; BC041591)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   218 AA;  24947 MW;  26538A61AB0AEB98 CRC64;
     MGRVFLTGEK ANSILKRYPR ANGFFEEIRQ GNIERECKEE FCTFEEAREA FENNEKTKEF
     WSTYTKAQQG ESNRGSDWFQ FYLTFPLIFG LFIILLVIFL IWRCFLRNKT RRQTVTEGHI
     PFPQHLNIIT PPPPPDEVFD SSGLSPGFLG YVVGRSDSVS TRLSNCDPPP TYEEATGQVN
     LQRSETEPHL DPPPEYEDIV NSNSASAIPM VPVVTTIK
 
 
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