TMG1_PONAB
ID TMG1_PONAB Reviewed; 218 AA.
AC Q5RCB6;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Transmembrane gamma-carboxyglutamic acid protein 1;
DE AltName: Full=Proline-rich gamma-carboxyglutamic acid protein 1;
DE Short=Proline-rich Gla protein 1;
DE Flags: Precursor;
GN Name=PRRG1; Synonyms=TMG1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- PTM: Gla residues are produced after subsequent post-translational
CC modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
CC {ECO:0000250}.
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DR EMBL; CR858360; CAH90591.1; -; mRNA.
DR RefSeq; NP_001125319.1; NM_001131847.1.
DR RefSeq; XP_009232979.1; XM_009234704.1.
DR RefSeq; XP_009232980.1; XM_009234705.1.
DR RefSeq; XP_009232981.1; XM_009234706.1.
DR RefSeq; XP_009232982.1; XM_009234707.1.
DR RefSeq; XP_009232983.1; XM_009234708.1.
DR AlphaFoldDB; Q5RCB6; -.
DR SMR; Q5RCB6; -.
DR STRING; 9601.ENSPPYP00000022644; -.
DR Ensembl; ENSPPYT00000023604; ENSPPYP00000022644; ENSPPYG00000020235.
DR GeneID; 100172218; -.
DR KEGG; pon:100172218; -.
DR CTD; 5638; -.
DR eggNOG; ENOG502RU75; Eukaryota.
DR GeneTree; ENSGT00950000182841; -.
DR HOGENOM; CLU_103591_0_0_1; -.
DR InParanoid; Q5RCB6; -.
DR OMA; WYSFYLA; -.
DR OrthoDB; 1305760at2759; -.
DR TreeFam; TF332123; -.
DR Proteomes; UP000001595; Chromosome X.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 4.10.740.10; -; 1.
DR InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR InterPro; IPR035972; GLA-like_dom_SF.
DR InterPro; IPR000294; GLA_domain.
DR Pfam; PF00594; Gla; 1.
DR PRINTS; PR00001; GLABLOOD.
DR SMART; SM00069; GLA; 1.
DR SUPFAM; SSF57630; SSF57630; 1.
DR PROSITE; PS00011; GLA_1; 1.
DR PROSITE; PS50998; GLA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT PROPEP 1..20
FT /evidence="ECO:0000255"
FT /id="PRO_0000352669"
FT CHAIN 21..218
FT /note="Transmembrane gamma-carboxyglutamic acid protein 1"
FT /id="PRO_0000352670"
FT TOPO_DOM 21..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 20..66
FT /note="Gla"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT REGION 161..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 37..42
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
SQ SEQUENCE 218 AA; 24933 MW; D037D9A7C90D9641 CRC64;
MGRVFLTGEK ANSVLKRYPR ANGFFEEIRQ GNIERECKEE FCTFEEAREA FENNEKTKEF
WSTYTKAQQG ESNRGSDWFQ FYLTFPLIFG LFIILLVIFL IWRCFLRNKT RRQTVTEGHI
PFPQHLNIIT PPPPPDEVFD SSGLSPGFLG YVVGRSDSVS TRLSNCDPPP TYEEATGQVN
LQRSETEPHL DPPPEYEDIV NSNSASAIPM VPVVTTIK