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TMG1_PONAB
ID   TMG1_PONAB              Reviewed;         218 AA.
AC   Q5RCB6;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Transmembrane gamma-carboxyglutamic acid protein 1;
DE   AltName: Full=Proline-rich gamma-carboxyglutamic acid protein 1;
DE            Short=Proline-rich Gla protein 1;
DE   Flags: Precursor;
GN   Name=PRRG1; Synonyms=TMG1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: Gla residues are produced after subsequent post-translational
CC       modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
CC       {ECO:0000250}.
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DR   EMBL; CR858360; CAH90591.1; -; mRNA.
DR   RefSeq; NP_001125319.1; NM_001131847.1.
DR   RefSeq; XP_009232979.1; XM_009234704.1.
DR   RefSeq; XP_009232980.1; XM_009234705.1.
DR   RefSeq; XP_009232981.1; XM_009234706.1.
DR   RefSeq; XP_009232982.1; XM_009234707.1.
DR   RefSeq; XP_009232983.1; XM_009234708.1.
DR   AlphaFoldDB; Q5RCB6; -.
DR   SMR; Q5RCB6; -.
DR   STRING; 9601.ENSPPYP00000022644; -.
DR   Ensembl; ENSPPYT00000023604; ENSPPYP00000022644; ENSPPYG00000020235.
DR   GeneID; 100172218; -.
DR   KEGG; pon:100172218; -.
DR   CTD; 5638; -.
DR   eggNOG; ENOG502RU75; Eukaryota.
DR   GeneTree; ENSGT00950000182841; -.
DR   HOGENOM; CLU_103591_0_0_1; -.
DR   InParanoid; Q5RCB6; -.
DR   OMA; WYSFYLA; -.
DR   OrthoDB; 1305760at2759; -.
DR   TreeFam; TF332123; -.
DR   Proteomes; UP000001595; Chromosome X.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 4.10.740.10; -; 1.
DR   InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR   InterPro; IPR035972; GLA-like_dom_SF.
DR   InterPro; IPR000294; GLA_domain.
DR   Pfam; PF00594; Gla; 1.
DR   PRINTS; PR00001; GLABLOOD.
DR   SMART; SM00069; GLA; 1.
DR   SUPFAM; SSF57630; SSF57630; 1.
DR   PROSITE; PS00011; GLA_1; 1.
DR   PROSITE; PS50998; GLA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   PROPEP          1..20
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000352669"
FT   CHAIN           21..218
FT                   /note="Transmembrane gamma-carboxyglutamic acid protein 1"
FT                   /id="PRO_0000352670"
FT   TOPO_DOM        21..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..66
FT                   /note="Gla"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT   REGION          161..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        37..42
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
SQ   SEQUENCE   218 AA;  24933 MW;  D037D9A7C90D9641 CRC64;
     MGRVFLTGEK ANSVLKRYPR ANGFFEEIRQ GNIERECKEE FCTFEEAREA FENNEKTKEF
     WSTYTKAQQG ESNRGSDWFQ FYLTFPLIFG LFIILLVIFL IWRCFLRNKT RRQTVTEGHI
     PFPQHLNIIT PPPPPDEVFD SSGLSPGFLG YVVGRSDSVS TRLSNCDPPP TYEEATGQVN
     LQRSETEPHL DPPPEYEDIV NSNSASAIPM VPVVTTIK
 
 
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