TMG3_MOUSE
ID TMG3_MOUSE Reviewed; 231 AA.
AC Q6PAQ9; A3KGD9; B2RPV1;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transmembrane gamma-carboxyglutamic acid protein 3;
DE AltName: Full=Proline-rich gamma-carboxyglutamic acid protein 3;
DE Short=Proline-rich Gla protein 3;
DE Flags: Precursor;
GN Name=Prrg3; Synonyms=Gm368, Tmg3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- PTM: Gla residues are produced after subsequent post-translational
CC modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC060135; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL731693; CAM46055.1; -; Genomic_DNA.
DR EMBL; BC137616; AAI37617.1; -; mRNA.
DR EMBL; BC137619; AAI37620.1; -; mRNA.
DR EMBL; BC060135; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS41001.1; -.
DR RefSeq; NP_001074604.1; NM_001081135.2.
DR RefSeq; NP_001289957.1; NM_001303028.1.
DR RefSeq; XP_006527987.1; XM_006527924.3.
DR RefSeq; XP_006527988.1; XM_006527925.3.
DR RefSeq; XP_006527989.1; XM_006527926.3.
DR RefSeq; XP_006527990.1; XM_006527927.3.
DR AlphaFoldDB; Q6PAQ9; -.
DR SMR; Q6PAQ9; -.
DR STRING; 10090.ENSMUSP00000038947; -.
DR iPTMnet; Q6PAQ9; -.
DR PhosphoSitePlus; Q6PAQ9; -.
DR PaxDb; Q6PAQ9; -.
DR PRIDE; Q6PAQ9; -.
DR ProteomicsDB; 259128; -.
DR Antibodypedia; 30695; 131 antibodies from 21 providers.
DR Ensembl; ENSMUST00000048790; ENSMUSP00000038947; ENSMUSG00000033361.
DR Ensembl; ENSMUST00000170096; ENSMUSP00000128073; ENSMUSG00000033361.
DR GeneID; 208748; -.
DR KEGG; mmu:208748; -.
DR UCSC; uc009tkh.2; mouse.
DR CTD; 79057; -.
DR MGI; MGI:2685214; Prrg3.
DR VEuPathDB; HostDB:ENSMUSG00000033361; -.
DR eggNOG; ENOG502RXJN; Eukaryota.
DR GeneTree; ENSGT00940000160946; -.
DR HOGENOM; CLU_103591_0_0_1; -.
DR InParanoid; Q6PAQ9; -.
DR OMA; TVYMVVP; -.
DR OrthoDB; 1305760at2759; -.
DR PhylomeDB; Q6PAQ9; -.
DR TreeFam; TF332123; -.
DR BioGRID-ORCS; 208748; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Prrg3; mouse.
DR PRO; PR:Q6PAQ9; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6PAQ9; protein.
DR Bgee; ENSMUSG00000033361; Expressed in sciatic nerve and 201 other tissues.
DR ExpressionAtlas; Q6PAQ9; baseline and differential.
DR Genevisible; Q6PAQ9; MM.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 4.10.740.10; -; 1.
DR InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
DR InterPro; IPR035972; GLA-like_dom_SF.
DR InterPro; IPR000294; GLA_domain.
DR Pfam; PF00594; Gla; 1.
DR PRINTS; PR00001; GLABLOOD.
DR SMART; SM00069; GLA; 1.
DR SUPFAM; SSF57630; SSF57630; 1.
DR PROSITE; PS00011; GLA_1; 1.
DR PROSITE; PS50998; GLA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Gamma-carboxyglutamic acid; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT PROPEP 1..19
FT /evidence="ECO:0000255"
FT /id="PRO_0000022549"
FT CHAIN 20..231
FT /note="Transmembrane gamma-carboxyglutamic acid protein 3"
FT /id="PRO_0000022550"
FT TOPO_DOM 20..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 20..65
FT /note="Gla"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT REGION 140..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 22
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 25
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 26
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 33
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 35
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 38
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 39
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 44
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 45
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 48
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 51
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 54
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT MOD_RES 58
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
FT DISULFID 36..41
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
SQ SEQUENCE 231 AA; 25877 MW; FFB97C767F6EA103 CRC64;
MAVFLEAKNA HAVLKRFPRA NEFLEELRQG TIERECMEEI CSYEEVKEVF ENKEKTMEFW
KGYPNAVYSV RDPSQSSDAM YVVVPLLGVV LLIVIALFII WRCQLQKATR HHPSYAQNRY
LASRAGHNLP RVMVYRGTVH SQGESSGHRE AGNNPQIVMG PSRGGRTTVR LESTLYLPEL
SLSRLSSATP PPSYEEVTAP QEGSSEEASV SYSDPPPKYE EIVAASPSAD K
