BTBD6_MOUSE
ID BTBD6_MOUSE Reviewed; 539 AA.
AC Q8K2J9; Q3UIB3;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=BTB/POZ domain-containing protein 6;
DE Flags: Precursor;
GN Name=Btbd6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Adapter protein for the cul3 E3 ubiquitin-protein ligase
CC complex (By similarity). Involved in late neuronal development and
CC muscle formation (By similarity). {ECO:0000250|UniProtKB:A9JRD8,
CC ECO:0000250|UniProtKB:Q2LE78}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q2LE78}.
CC Note=Found in punctated bodies in the cytoplasm.
CC {ECO:0000250|UniProtKB:Q2LE78}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K2J9-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K2J9-1; Sequence=VSP_061437;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH31195.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK146991; BAE27593.1; -; mRNA.
DR EMBL; CH466549; EDL18570.1; -; Genomic_DNA.
DR EMBL; BC031195; AAH31195.1; ALT_INIT; mRNA.
DR CCDS; CCDS49193.1; -. [Q8K2J9-2]
DR CCDS; CCDS49194.1; -. [Q8K2J9-1]
DR RefSeq; NP_001139372.1; NM_001145900.1.
DR RefSeq; NP_964008.2; NM_201646.2.
DR RefSeq; XP_006516119.1; XM_006516056.3.
DR AlphaFoldDB; Q8K2J9; -.
DR SMR; Q8K2J9; -.
DR STRING; 10090.ENSMUSP00000002880; -.
DR PhosphoSitePlus; Q8K2J9; -.
DR PaxDb; Q8K2J9; -.
DR PRIDE; Q8K2J9; -.
DR ProteomicsDB; 273559; -.
DR Antibodypedia; 15012; 162 antibodies from 29 providers.
DR DNASU; 399566; -.
DR Ensembl; ENSMUST00000002880; ENSMUSP00000002880; ENSMUSG00000002803. [Q8K2J9-2]
DR Ensembl; ENSMUST00000165079; ENSMUSP00000127286; ENSMUSG00000002803. [Q8K2J9-1]
DR Ensembl; ENSMUST00000221104; ENSMUSP00000152889; ENSMUSG00000002803. [Q8K2J9-1]
DR GeneID; 399566; -.
DR KEGG; mmu:399566; -.
DR UCSC; uc011yvh.1; mouse. [Q8K2J9-2]
DR CTD; 90135; -.
DR MGI; MGI:3026623; Btbd6.
DR VEuPathDB; HostDB:ENSMUSG00000002803; -.
DR eggNOG; KOG2075; Eukaryota.
DR GeneTree; ENSGT00940000155720; -.
DR HOGENOM; CLU_015899_2_1_1; -.
DR InParanoid; Q8K2J9; -.
DR OMA; AKACVHF; -.
DR OrthoDB; 660286at2759; -.
DR PhylomeDB; Q8K2J9; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 399566; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q8K2J9; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8K2J9; protein.
DR Bgee; ENSMUSG00000002803; Expressed in embryonic brain and 218 other tissues.
DR ExpressionAtlas; Q8K2J9; baseline and differential.
DR Genevisible; Q8K2J9; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022008; P:neurogenesis; IBA:GO_Central.
DR Gene3D; 2.60.120.820; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR012983; PHR.
DR InterPro; IPR038648; PHR_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF08005; PHR; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..539
FT /note="BTB/POZ domain-containing protein 6"
FT /evidence="ECO:0000255"
FT /id="PRO_0000186214"
FT DOMAIN 137..207
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT VAR_SEQ 1..51
FT /note="Missing (in isoform 2)"
FT /id="VSP_061437"
SQ SEQUENCE 539 AA; 59100 MW; F6C1BF37278298C3 CRC64;
MLLPLACLHG RVAQCLTSLL VLAEPFPRPR RGAKARGAAP TSAEPAPAVA KMAAELYPPA
SPSAATATDI ANSNAAGAAE STKVGLCCPP CLAPAPLPPL PAPPLPDNNN PESPNWQSFH
PTLRERNALM FNNELMADVH FIVGALGAAR RVPAHKYVLA VGSSVFYAMF YGDLAEVKSE
IHIPDVEPAA FLVLLKYMYS DEIDLEADTV LATLYAAKKY IVPALAKACV NFLETSLEAK
NACVLLSQSR LFEEPELTQR CWEVIDAQAE MALRSEGFCE IDRQTLEIIV TREALNTKEA
VVFEAVLNWA EAECKRQGLP VTPHNKRHVL GRALYLVRIP TMTLEEFANG AAQSDILTLE
ETHNIFLWYT AAKKPLLDFP LTKRKGLAPQ RCHRFQSSAY RSNQWRYRGR CDSIQFAVDR
RVFIAGLGLY GSSSGKAEYS VKIELKRLGM VLAQNLTKFV SDGSSNTFPV WFEHPVQVEQ
DTFYTASAVL DGSELSYFGQ EGMTEVQCGK VAFQFQCSSD STNGTGVQGG QIPELIFYA
