TMIG1_HUMAN
ID TMIG1_HUMAN Reviewed; 262 AA.
AC Q6UXZ0; A8K2K1; Q6ZMC6;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transmembrane and immunoglobulin domain-containing protein 1;
DE Flags: Precursor;
GN Name=TMIGD1 {ECO:0000312|HGNC:HGNC:32431};
GN Synonyms=TMIGD {ECO:0000312|HGNC:HGNC:32431}; ORFNames=UNQ9372/PRO34164;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Colon, and Ileal mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, AND FUNCTION.
RX PubMed=26342724; DOI=10.1016/j.ajpath.2015.06.006;
RA Arafa E., Bondzie P.A., Rezazadeh K., Meyer R.D., Hartsough E.,
RA Henderson J.M., Schwartz J.H., Chitalia V., Rahimi N.;
RT "TMIGD1 is a novel adhesion molecule that protects epithelial cells from
RT oxidative cell injury.";
RL Am. J. Pathol. 185:2757-2767(2015).
CC -!- FUNCTION: May control cell-cell adhesion, cell migration and
CC proliferation, cell morphology, and protects renal epithelial cells
CC from oxidative cell injury to promote cell survival.
CC {ECO:0000269|PubMed:26342724}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:26342724}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26342724};
CC Single-pass type I membrane protein {ECO:0000305}. Cytoplasm
CC {ECO:0000269|PubMed:26342724}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UXZ0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UXZ0-2; Sequence=VSP_017075, VSP_017076;
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:26342724}.
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DR EMBL; AK172838; BAD18803.1; -; mRNA.
DR EMBL; AK290266; BAF82955.1; -; mRNA.
DR EMBL; AY358153; AAQ88520.1; -; mRNA.
DR CCDS; CCDS32605.1; -. [Q6UXZ0-1]
DR CCDS; CCDS82099.1; -. [Q6UXZ0-2]
DR RefSeq; NP_001306871.1; NM_001319942.1. [Q6UXZ0-2]
DR RefSeq; NP_996663.1; NM_206832.2. [Q6UXZ0-1]
DR RefSeq; XP_011523089.1; XM_011524787.1. [Q6UXZ0-1]
DR AlphaFoldDB; Q6UXZ0; -.
DR SMR; Q6UXZ0; -.
DR BioGRID; 132662; 1.
DR IntAct; Q6UXZ0; 2.
DR MINT; Q6UXZ0; -.
DR STRING; 9606.ENSP00000332404; -.
DR GlyGen; Q6UXZ0; 5 sites.
DR iPTMnet; Q6UXZ0; -.
DR PhosphoSitePlus; Q6UXZ0; -.
DR BioMuta; TMIGD1; -.
DR DMDM; 74758583; -.
DR MassIVE; Q6UXZ0; -.
DR PaxDb; Q6UXZ0; -.
DR PeptideAtlas; Q6UXZ0; -.
DR PRIDE; Q6UXZ0; -.
DR ProteomicsDB; 67681; -. [Q6UXZ0-1]
DR ProteomicsDB; 67682; -. [Q6UXZ0-2]
DR TopDownProteomics; Q6UXZ0-2; -. [Q6UXZ0-2]
DR Antibodypedia; 15126; 60 antibodies from 22 providers.
DR DNASU; 388364; -.
DR Ensembl; ENST00000328886.5; ENSP00000332404.4; ENSG00000182271.13. [Q6UXZ0-1]
DR Ensembl; ENST00000538566.6; ENSP00000446118.2; ENSG00000182271.13. [Q6UXZ0-2]
DR GeneID; 388364; -.
DR KEGG; hsa:388364; -.
DR MANE-Select; ENST00000328886.5; ENSP00000332404.4; NM_206832.3; NP_996663.1.
DR UCSC; uc002hfa.1; human. [Q6UXZ0-1]
DR CTD; 388364; -.
DR DisGeNET; 388364; -.
DR GeneCards; TMIGD1; -.
DR HGNC; HGNC:32431; TMIGD1.
DR HPA; ENSG00000182271; Tissue enriched (intestine).
DR neXtProt; NX_Q6UXZ0; -.
DR OpenTargets; ENSG00000182271; -.
DR PharmGKB; PA142670725; -.
DR VEuPathDB; HostDB:ENSG00000182271; -.
DR eggNOG; ENOG502RZZ3; Eukaryota.
DR GeneTree; ENSGT00510000048311; -.
DR HOGENOM; CLU_082747_0_0_1; -.
DR InParanoid; Q6UXZ0; -.
DR OMA; VQNHTRD; -.
DR OrthoDB; 1099491at2759; -.
DR PhylomeDB; Q6UXZ0; -.
DR TreeFam; TF336634; -.
DR PathwayCommons; Q6UXZ0; -.
DR SignaLink; Q6UXZ0; -.
DR BioGRID-ORCS; 388364; 5 hits in 1057 CRISPR screens.
DR ChiTaRS; TMIGD1; human.
DR GenomeRNAi; 388364; -.
DR Pharos; Q6UXZ0; Tbio.
DR PRO; PR:Q6UXZ0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6UXZ0; protein.
DR Bgee; ENSG00000182271; Expressed in rectum and 30 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; IDA:UniProtKB.
DR GO; GO:0042127; P:regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0090559; P:regulation of membrane permeability; IMP:UniProtKB.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cytoplasm; Disulfide bond;
KW Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..262
FT /note="Transmembrane and immunoglobulin domain-containing
FT protein 1"
FT /id="PRO_0000045790"
FT TOPO_DOM 30..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..114
FT /note="Ig-like C2-type 1"
FT DOMAIN 122..207
FT /note="Ig-like C2-type 2"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 54..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 143..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 214..218
FT /note="DKTVG -> ALHEG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_017075"
FT VAR_SEQ 219..262
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_017076"
SQ SEQUENCE 262 AA; 29185 MW; 004383C6D7948952 CRC64;
MAWKSSVIMQ MGRFLLLVIL FLPREMTSSV LTVNGKTENY ILDTTPGSQA SLICAVQNHT
REEELLWYRE EGRVDLKSGN KINSSSVCVS SISENDNGIS FTCRLGRDQS VSVSVVLNVT
FPPLLSGNDF QTVEEGSNVK LVCNVKANPQ AQMMWYKNSS LLDLEKSRHQ IQQTSESFQL
SITKVEKPDN GTYSCIAKSS LKTESLDFHL IVKDKTVGVP IEPIIAACVV IFLTLCFGLI
ARRKKIMKLC MKDKDPHSET AL
