TMIG3_MOUSE
ID TMIG3_MOUSE Reviewed; 209 AA.
AC G3X8R9; Q9DAR9;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Transmembrane domain-containing protein TMIGD3;
DE Flags: Precursor;
GN Name=Tmigd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P0DMS9}; Single-
CC pass type I membrane protein {ECO:0000255}.
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DR EMBL; AK005581; BAB24135.1; -; mRNA.
DR EMBL; AC121847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466608; EDL07540.1; -; Genomic_DNA.
DR CCDS; CCDS38582.1; -.
DR RefSeq; NP_081301.2; NM_027025.4.
DR AlphaFoldDB; G3X8R9; -.
DR SMR; G3X8R9; -.
DR STRING; 10090.ENSMUSP00000010279; -.
DR PhosphoSitePlus; G3X8R9; -.
DR PaxDb; G3X8R9; -.
DR PRIDE; G3X8R9; -.
DR ProteomicsDB; 259255; -.
DR Antibodypedia; 20120; 88 antibodies from 19 providers.
DR DNASU; 11542; -.
DR Ensembl; ENSMUST00000010279; ENSMUSP00000010279; ENSMUSG00000074344.
DR Ensembl; ENSMUST00000198080; ENSMUSP00000143300; ENSMUSG00000074344.
DR GeneID; 69296; -.
DR KEGG; mmu:69296; -.
DR UCSC; uc008qvh.3; mouse.
DR CTD; 57413; -.
DR MGI; MGI:5604098; Tmigd3.
DR VEuPathDB; HostDB:ENSMUSG00000074344; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00930000151073; -.
DR OMA; VHFLPVM; -.
DR PhylomeDB; G3X8R9; -.
DR TreeFam; TF334441; -.
DR BioGRID-ORCS; 69296; 0 hits in 32 CRISPR screens.
DR PRO; PR:G3X8R9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; G3X8R9; protein.
DR Bgee; ENSMUSG00000074344; Expressed in spermatid and 20 other tissues.
DR ExpressionAtlas; G3X8R9; baseline and differential.
DR Genevisible; Q9DAR9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..209
FT /note="Transmembrane domain-containing protein TMIGD3"
FT /id="PRO_0000441841"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 179..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 80
FT /note="I -> V (in Ref. 1; BAB24135)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 209 AA; 23452 MW; B4596AE7FA1FC1AB CRC64;
MEFLLLLSLA LFSDAMVMDE KVKSGVELET ASAVCVYDAY YKDHTKYWCR GYFRDSCNII
AFTPNSTNRV ALKDTGNQLI ITISCLVKED TGWYWCGIQR DLARDDMDFT QLIVTDNRED
RANGFSSDPS GNRTRSCRAS KAVQKAEGSR MSILIICILI TSLGIIFIIS HLSRGRRSQR
NREVTGKSIS RNPQASQGPS MVSITLARI
