ID   BTBD6_XENLA             Reviewed;         529 AA.
AC   Q2LE78;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=BTB/POZ domain-containing protein 6;
GN   Name=btbd6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bury F.J., Moers V., Bellefroid E.J.;
RT   "XBTBD6, a XCullin-3 interacting Protein, is expressed during neurogenesis
RT   in Xenopus laevis.";
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, SUBUNIT, DEVELOPMENTAL STAGE, SUBCELLULAR
RP   LOCATION, AND INTERACTION WITH CUL3.
RX   PubMed=18855900; DOI=10.1002/dvdy.21748;
RA   Bury F.J., Moers V., Yan J., Souopgui J., Quan X.J., De Geest N.,
RA   Kricha S., Hassan B.A., Bellefroid E.J.;
RT   "Xenopus BTBD6 and its Drosophila homologue lute are required for neuronal
RT   development.";
RL   Dev. Dyn. 237:3352-3360(2008).
CC   -!- FUNCTION: Adapter protein for the cul3 E3 ubiquitin-protein ligase
CC       complex (By similarity). Involved in late neuronal development and
CC       muscle formation (PubMed:18855900). {ECO:0000250|UniProtKB:A9JRD8,
CC       ECO:0000269|PubMed:18855900}.
CC   -!- SUBUNIT: Homodimer and heterodimer. Interacts with cul3 via the BTB
CC       domain. {ECO:0000269|PubMed:18855900}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18855900}.
CC       Note=Found in punctated bodies in the cytoplasm.
CC       {ECO:0000269|PubMed:18855900}.
CC   -!- DEVELOPMENTAL STAGE: Highly expressed in the developing nervous system.
CC       {ECO:0000269|PubMed:18855900}.
CC   -!- DISRUPTION PHENOTYPE: Embryos show strong defects in late neuronal
CC       markers and strongly reduced and disorganized axons while early neural
CC       development is unaffected. Muscle development is also affected.
CC       {ECO:0000269|PubMed:18855900}.
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DR   EMBL; DQ327672; ABC59313.1; -; mRNA.
DR   EMBL; BC169436; AAI69436.1; -; mRNA.
DR   EMBL; BC169440; AAI69440.1; -; mRNA.
DR   RefSeq; NP_001082188.1; NM_001088719.1.
DR   AlphaFoldDB; Q2LE78; -.
DR   SMR; Q2LE78; -.
DR   GeneID; 398279; -.
DR   KEGG; xla:398279; -.
DR   CTD; 398279; -.
DR   Xenbase; XB-GENE-6251792; btbd6.L.
DR   OMA; QACYEIV; -.
DR   OrthoDB; 660286at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 398279; Expressed in camera-type eye and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.120.820; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR012983; PHR.
DR   InterPro; IPR038648; PHR_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF08005; PHR; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..529
FT                   /note="BTB/POZ domain-containing protein 6"
FT                   /id="PRO_0000380250"
FT   DOMAIN          127..197
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ   SEQUENCE   529 AA;  58919 MW;  E2CF0E80DEA2A898 CRC64;
     MPLDPGCLNG RVMKCLTFFL LLPETLKKSR KSARAQGKVQ ACYEIVPLAL KKKMAAELYP
     ASANTNIANS NATANAKKNA LQLQHTAPPP PQLHNLNNNN IESSNWQSFH PTLRERNALM
     FNNELMADVH FIVGPAGASK KVPAHKYILA VGSSVFYAMF YGDLAEVKSE IHIPDVEPAA
     FLILLKYLYS DEIDLEADTV LATLYAAKKY IVPALAKACV NFLETSLEAK NACVLLSQSR
     LFEEPDLTLR CWEVIDAQAE LALKSEGFCE IDLPTLEIIV TRETLNTKED VVFEAVLNWA
     EAECKRQGLP ITPVNKRNVL GKALYLVRIP TMTLEEFANG AAQSDILTLE ETRSIFLWYT
     AANKPQLEFP LIKRKGLAPQ RCHRFQSSAY RSNQWRYRGR CDSIQFAVDK RIFIAGLGLY
     GSSCGKAEYS VKIELKRQGV VLAQNLTKFV SDGCSNTFSV WFEHPVQVEQ DTFYTVSAIL
     DGNELSYFGQ EGMTEVQCGK VTFQFQCSSD STNGTGVQGG QIPELIFYA