ID   BTBD6_XENTR             Reviewed;         529 AA.
AC   Q0V9W6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=BTB/POZ domain-containing protein 6;
GN   Name=btbd6;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein for the cul3 E3 ubiquitin-protein ligase
CC       complex (By similarity). Involved in late neuronal development and
CC       muscle formation (By similarity). {ECO:0000250|UniProtKB:A9JRD8,
CC       ECO:0000250|UniProtKB:Q2LE78}.
CC   -!- SUBUNIT: Homodimer and heterodimer. Interacts with cul3 via the BTB
CC       domain. {ECO:0000250|UniProtKB:Q2LE78}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q2LE78}.
CC       Note=Found in punctated bodies in the cytoplasm.
CC       {ECO:0000250|UniProtKB:Q2LE78}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI21369.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC121368; AAI21369.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q0V9W6; -.
DR   SMR; Q0V9W6; -.
DR   STRING; 8364.ENSXETP00000015189; -.
DR   PaxDb; Q0V9W6; -.
DR   PRIDE; Q0V9W6; -.
DR   eggNOG; KOG2075; Eukaryota.
DR   InParanoid; Q0V9W6; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0022008; P:neurogenesis; IBA:GO_Central.
DR   Gene3D; 2.60.120.820; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR012983; PHR.
DR   InterPro; IPR038648; PHR_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF08005; PHR; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..529
FT                   /note="BTB/POZ domain-containing protein 6"
FT                   /id="PRO_0000380251"
FT   DOMAIN          127..197
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ   SEQUENCE   529 AA;  58825 MW;  2F245DEDC4EBD155 CRC64;
     MPLDPGCLNG RVMKCLTFFL LLPETLKKSR KSARAQGKVQ ACYEIVPLAL KKKMAAELYP
     ASANTNIANS NAAANAKKNA LQLQQAAPPP PQLHNLNNNN IESGNWQSFH PTLRERNALM
     FNNELMADVH FIVGPAGASK KVPVHKYILA VGSSVFYAMF YGDLAEVKSE IHIPDVEPAA
     FLILLKYLYS DEIDLEADTV LATLYAAKKY IVPALAKACV NFLETSLEAK NACVLLSQSR
     LFEEPDLTLR CWEVIDAQAE LALKSEGFCE IDLQTLEIIV TRETLNTKED VVFEAVLNWA
     EAECKRQGLS ITPVNKRNVL GKALYLVRIP TMTLEEFANG AAQSDILTLE ETRSIFLWYT
     AANKPQLEFP LIKRKGLAPQ RCHRFQSSAY RSNQWRYRGR CDSIQFAVDK RIFIAGLGLY
     GSSCGKAEYS VKIELKRQGA VLAQNLTKFV SDGSSNTFSV WFEHPVQVEQ DTFYTVSAIL
     DGNELSYFGQ EGMTEVQCGK VTFQFQCSSD STNGTGVQGG QIPELIFYA