ID   TMM11_BOVIN             Reviewed;         192 AA.
AC   A5D7N3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transmembrane protein 11, mitochondrial;
GN   Name=TMEM11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in mitochondrial morphogenesis.
CC       {ECO:0000250|UniProtKB:P17152}.
CC   -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex, composed of at least MICOS10/MIC10,
CC       CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26
CC       and QIL1/MIC13. This complex was also known under the names MINOS or
CC       MitOS complex. The MICOS complex associates with mitochondrial outer
CC       membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner
CC       membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.
CC       {ECO:0000250|UniProtKB:P17152}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P17152}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P17152}.
CC   -!- SIMILARITY: Belongs to the TMEM11 family. {ECO:0000305}.
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DR   EMBL; BC140623; AAI40624.1; -; mRNA.
DR   RefSeq; NP_001091467.1; NM_001097998.2.
DR   AlphaFoldDB; A5D7N3; -.
DR   STRING; 9913.ENSBTAP00000013971; -.
DR   PaxDb; A5D7N3; -.
DR   PRIDE; A5D7N3; -.
DR   Ensembl; ENSBTAT00000013971; ENSBTAP00000013971; ENSBTAG00000010566.
DR   GeneID; 508598; -.
DR   KEGG; bta:508598; -.
DR   CTD; 8834; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010566; -.
DR   VGNC; VGNC:35950; TMEM11.
DR   eggNOG; ENOG502QUAI; Eukaryota.
DR   GeneTree; ENSGT00390000006617; -.
DR   HOGENOM; CLU_095460_0_0_1; -.
DR   InParanoid; A5D7N3; -.
DR   OMA; LYTVSWQ; -.
DR   OrthoDB; 1222072at2759; -.
DR   TreeFam; TF324685; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000010566; Expressed in laryngeal cartilage and 106 other tissues.
DR   ExpressionAtlas; A5D7N3; baseline.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   InterPro; IPR026120; TMEM11.
DR   PANTHER; PTHR15099; PTHR15099; 1.
DR   Pfam; PF14972; Mito_morph_reg; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..192
FT                   /note="Transmembrane protein 11, mitochondrial"
FT                   /id="PRO_0000367036"
FT   TRANSMEM        84..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   192 AA;  21479 MW;  289C0D6BBA5D44BB CRC64;
     MAAWGRRRLG PGSGGGGARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE QALEAQYKYI
     VIEPTRIGDE TARWITVGNC LHKTTVLAGT ACLFTPLALP LDYSHYISLP AGVLSLACCT
     LYGISWQFDP CCKYQVEYDA YRLSRLPLHT LTSSTPVVLV RKDDLHRKRL HNTIALAALV
     YCVKKIYELC AV