TMM11_DROME
ID TMM11_DROME Reviewed; 182 AA.
AC Q8IQ56; Q9VRP7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transmembrane protein 11 homolog, mitochondrial;
DE AltName: Full=Protein PMI;
GN Name=Pmi; ORFNames=CG33718;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=11106397; DOI=10.1073/pnas.97.25.13772;
RA Werner T., Liu G., Kang D., Ekengren S., Steiner H., Hultmark D.;
RT "A family of peptidoglycan recognition proteins in the fruit fly Drosophila
RT melanogaster.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:13772-13777(2000).
RN [4] {ECO:0000305}
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo {ECO:0000269|PubMed:18327897};
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21274005; DOI=10.1038/embor.2010.214;
RA Rival T., Macchi M., Arnaune-Pelloquin L., Poidevin M., Maillet F.,
RA Richard F., Fatmi A., Belenguer P., Royet J.;
RT "Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis
RT independently of the DRP1/MFN fission/fusion pathways.";
RL EMBO Rep. 12:223-230(2011).
CC -!- FUNCTION: Plays a role in mitochondrial morphogenesis.
CC {ECO:0000269|PubMed:21274005}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000305|PubMed:21274005}; Multi-pass membrane protein
CC {ECO:0000305|PubMed:21274005}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B {ECO:0000269|PubMed:10731132};
CC IsoId=Q8IQ56-1; Sequence=Displayed;
CC Name=A {ECO:0000269|PubMed:10731132};
CC IsoId=Q8IQ56-2; Sequence=VSP_053044;
CC -!- SIMILARITY: Belongs to the TMEM11 family. {ECO:0000255}.
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DR EMBL; AE014296; AAF50746.3; -; Genomic_DNA.
DR EMBL; AE014296; AAN12113.3; -; Genomic_DNA.
DR RefSeq; NP_001027109.2; NM_001031938.3. [Q8IQ56-1]
DR RefSeq; NP_001027110.2; NM_001031939.3. [Q8IQ56-2]
DR RefSeq; NP_001303405.1; NM_001316476.1. [Q8IQ56-2]
DR RefSeq; NP_001334670.1; NM_001347759.1. [Q8IQ56-2]
DR AlphaFoldDB; Q8IQ56; -.
DR IntAct; Q8IQ56; 16.
DR MINT; Q8IQ56; -.
DR STRING; 7227.FBpp0289218; -.
DR iPTMnet; Q8IQ56; -.
DR PaxDb; Q8IQ56; -.
DR PRIDE; Q8IQ56; -.
DR DNASU; 3772100; -.
DR EnsemblMetazoa; FBtr0299940; FBpp0289217; FBgn0044419. [Q8IQ56-2]
DR EnsemblMetazoa; FBtr0299941; FBpp0289218; FBgn0044419. [Q8IQ56-1]
DR EnsemblMetazoa; FBtr0347274; FBpp0312522; FBgn0044419. [Q8IQ56-2]
DR EnsemblMetazoa; FBtr0445398; FBpp0401566; FBgn0044419. [Q8IQ56-2]
DR GeneID; 3772100; -.
DR KEGG; dme:Dmel_CG33718; -.
DR UCSC; CG33718-RC; d. melanogaster.
DR CTD; 3772100; -.
DR FlyBase; FBgn0044419; Pmi.
DR VEuPathDB; VectorBase:FBgn0044419; -.
DR eggNOG; ENOG502QUAI; Eukaryota.
DR GeneTree; ENSGT00390000006617; -.
DR InParanoid; Q8IQ56; -.
DR OMA; LYTVSWQ; -.
DR PhylomeDB; Q8IQ56; -.
DR BioGRID-ORCS; 3772100; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 3772100; -.
DR PRO; PR:Q8IQ56; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0044419; Expressed in Malpighian tubule and 11 other tissues.
DR Genevisible; Q8IQ56; DM.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IMP:FlyBase.
DR GO; GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IMP:FlyBase.
DR GO; GO:0070584; P:mitochondrion morphogenesis; IMP:FlyBase.
DR GO; GO:0007005; P:mitochondrion organization; IMP:UniProtKB.
DR InterPro; IPR026120; TMEM11.
DR PANTHER; PTHR15099; PTHR15099; 1.
DR Pfam; PF14972; Mito_morph_reg; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..182
FT /note="Transmembrane protein 11 homolog, mitochondrial"
FT /id="PRO_0000367035"
FT TRANSMEM 70..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 173..182
FT /note="NRFVHSAGSG -> K (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10731132"
FT /id="VSP_053044"
SQ SEQUENCE 182 AA; 20333 MW; 60C2EF945E82ED71 CRC64;
MVSRNIESTS KVPTFHVIRE VYDSSNAHER FEAELDKALE AKLDFIVIEP PRLGDETGRW
IWVGNCLHKT AVATGVVSLV ASLLWRDRPI IAAPACALSI FCTGLYTVSW NYDPCCQYQV
ENNDTVLEKL PLTDVSSPVI LGYSPNSKTK YLHRSVSLLS AALCAWQIWR SYNRFVHSAG
SG
