TMM11_MOUSE
ID TMM11_MOUSE Reviewed; 190 AA.
AC Q8BK08; Q5NCT6;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane protein 11, mitochondrial;
DE AltName: Full=Protein PM1;
GN Name=Tmem11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in mitochondrial morphogenesis.
CC {ECO:0000250|UniProtKB:P17152}.
CC -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC organizing system (MICOS) complex, composed of at least MICOS10/MIC10,
CC CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26
CC and QIL1/MIC13. This complex was also known under the names MINOS or
CC MitOS complex. The MICOS complex associates with mitochondrial outer
CC membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner
CC membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.
CC {ECO:0000250|UniProtKB:P17152}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P17152}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P17152}.
CC -!- SIMILARITY: Belongs to the TMEM11 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI35260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK077600; BAC36891.1; -; mRNA.
DR EMBL; AL596215; CAI35259.1; -; Genomic_DNA.
DR EMBL; AL596215; CAI35260.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC048514; AAH48514.1; -; mRNA.
DR CCDS; CCDS24801.1; -.
DR RefSeq; NP_775655.1; NM_173453.3.
DR AlphaFoldDB; Q8BK08; -.
DR BioGRID; 229795; 3.
DR IntAct; Q8BK08; 1.
DR MINT; Q8BK08; -.
DR STRING; 10090.ENSMUSP00000059494; -.
DR iPTMnet; Q8BK08; -.
DR PhosphoSitePlus; Q8BK08; -.
DR SwissPalm; Q8BK08; -.
DR EPD; Q8BK08; -.
DR jPOST; Q8BK08; -.
DR MaxQB; Q8BK08; -.
DR PaxDb; Q8BK08; -.
DR PeptideAtlas; Q8BK08; -.
DR PRIDE; Q8BK08; -.
DR ProteomicsDB; 259428; -.
DR Antibodypedia; 26137; 67 antibodies from 16 providers.
DR DNASU; 216821; -.
DR Ensembl; ENSMUST00000062677; ENSMUSP00000059494; ENSMUSG00000043284.
DR GeneID; 216821; -.
DR KEGG; mmu:216821; -.
DR UCSC; uc007jgs.2; mouse.
DR CTD; 8834; -.
DR MGI; MGI:2144726; Tmem11.
DR VEuPathDB; HostDB:ENSMUSG00000043284; -.
DR eggNOG; ENOG502QUAI; Eukaryota.
DR GeneTree; ENSGT00390000006617; -.
DR HOGENOM; CLU_095460_0_0_1; -.
DR InParanoid; Q8BK08; -.
DR OMA; LYTVSWQ; -.
DR OrthoDB; 1222072at2759; -.
DR PhylomeDB; Q8BK08; -.
DR TreeFam; TF324685; -.
DR BioGRID-ORCS; 216821; 6 hits in 70 CRISPR screens.
DR ChiTaRS; Tmem11; mouse.
DR PRO; PR:Q8BK08; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BK08; protein.
DR Bgee; ENSMUSG00000043284; Expressed in embryonic brain and 258 other tissues.
DR ExpressionAtlas; Q8BK08; baseline and differential.
DR Genevisible; Q8BK08; MM.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR InterPro; IPR026120; TMEM11.
DR PANTHER; PTHR15099; PTHR15099; 1.
DR Pfam; PF14972; Mito_morph_reg; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..190
FT /note="Transmembrane protein 11, mitochondrial"
FT /id="PRO_0000072563"
FT TRANSMEM 84..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..124
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 190 AA; 21312 MW; 84ECC3BA30BB2EA5 CRC64;
MAAWGRRRLG PGGGGSRERV SLSATDCYIV HEIYSGENAQ DQFEYELEQA LEAQYKYIVI
EPTRIGDETA RWITVGNCLH KTAVLAGTAC LFTPLALPLD YSHYISLPAG VLSLACCTLY
GISWQFDPCC KYQVEYDAYK LSRLPLHTLT SSTPVVLVRK DDLHRKRLHN TIALAALVYC
VKKVYELYAV
