ID   TMM11_RAT               Reviewed;         190 AA.
AC   B0BN86;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Transmembrane protein 11, mitochondrial;
GN   Name=Tmem11;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in mitochondrial morphogenesis.
CC       {ECO:0000250|UniProtKB:P17152}.
CC   -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex, composed of at least MICOS10/MIC10,
CC       CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26
CC       and QIL1/MIC13. This complex was also known under the names MINOS or
CC       MitOS complex. The MICOS complex associates with mitochondrial outer
CC       membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner
CC       membrane protein TMEM11 and with HSPA9. Interacts with IMMT/MIC60.
CC       {ECO:0000250|UniProtKB:P17152}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P17152}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P17152}.
CC   -!- SIMILARITY: Belongs to the TMEM11 family. {ECO:0000305}.
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DR   EMBL; BC158725; AAI58726.1; -; mRNA.
DR   RefSeq; NP_001158015.1; NM_001164543.1.
DR   RefSeq; NP_001159637.1; NM_001166165.1.
DR   AlphaFoldDB; B0BN86; -.
DR   STRING; 10116.ENSRNOP00000007158; -.
DR   PaxDb; B0BN86; -.
DR   PeptideAtlas; B0BN86; -.
DR   PRIDE; B0BN86; -.
DR   Ensembl; ENSRNOT00000007158; ENSRNOP00000007158; ENSRNOG00000005377.
DR   GeneID; 303196; -.
DR   KEGG; rno:303196; -.
DR   UCSC; RGD:1309817; rat.
DR   CTD; 8834; -.
DR   RGD; 1309817; Tmem11.
DR   eggNOG; ENOG502QUAI; Eukaryota.
DR   GeneTree; ENSGT00390000006617; -.
DR   HOGENOM; CLU_095460_0_0_1; -.
DR   InParanoid; B0BN86; -.
DR   OMA; LYTVSWQ; -.
DR   OrthoDB; 1222072at2759; -.
DR   PhylomeDB; B0BN86; -.
DR   TreeFam; TF324685; -.
DR   PRO; PR:B0BN86; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000005377; Expressed in quadriceps femoris and 20 other tissues.
DR   ExpressionAtlas; B0BN86; baseline and differential.
DR   Genevisible; B0BN86; RN.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR   InterPro; IPR026120; TMEM11.
DR   PANTHER; PTHR15099; PTHR15099; 1.
DR   Pfam; PF14972; Mito_morph_reg; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..190
FT                   /note="Transmembrane protein 11, mitochondrial"
FT                   /id="PRO_0000367037"
FT   TRANSMEM        84..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   190 AA;  21342 MW;  F238D7B546605875 CRC64;
     MAAWGRRRLG PGGGSSRERV SLSATDCYIV HEIYSGENAQ DQFEYELEQA LEAQYKYIVI
     EPTRIGDETA RWITVGNCLH KTAVLAGTAC LFTPLALPLD YSHYISLPAG VLSLACCTLY
     GISWQFDPCC KYQVEYDAYK LSRLPLHTLT SSTPVVLVRK DDLHRKRLHN TIALAALVYC
     VKKVYELYAV