ID   TMM17_BOVIN             Reviewed;         198 AA.
AC   A4FUY9;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Transmembrane protein 17;
GN   Name=TMEM17;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC       complex localized at the transition zone of primary cilia and acting as
CC       a barrier that prevents diffusion of transmembrane proteins between the
CC       cilia and plasma membranes. Required for ciliogenesis and sonic
CC       hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC       transition zone of primary cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM17 family. {ECO:0000305}.
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DR   EMBL; DAAA02031394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC123468; AAI23469.1; -; mRNA.
DR   RefSeq; NP_001076902.1; NM_001083433.1.
DR   AlphaFoldDB; A4FUY9; -.
DR   STRING; 9913.ENSBTAP00000042266; -.
DR   PaxDb; A4FUY9; -.
DR   PRIDE; A4FUY9; -.
DR   Ensembl; ENSBTAT00000044807; ENSBTAP00000042266; ENSBTAG00000000899.
DR   GeneID; 514758; -.
DR   KEGG; bta:514758; -.
DR   CTD; 200728; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000899; -.
DR   VGNC; VGNC:35995; TMEM17.
DR   eggNOG; KOG4694; Eukaryota.
DR   GeneTree; ENSGT00940000153899; -.
DR   HOGENOM; CLU_092836_0_0_1; -.
DR   InParanoid; A4FUY9; -.
DR   OMA; YFFPFWW; -.
DR   OrthoDB; 1544916at2759; -.
DR   TreeFam; TF323824; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000000899; Expressed in spermatocyte and 105 other tissues.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019184; Uncharacterised_TM-17.
DR   PANTHER; PTHR13531; PTHR13531; 1.
DR   Pfam; PF09799; Transmemb_17; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..198
FT                   /note="Transmembrane protein 17"
FT                   /id="PRO_0000415836"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  23120 MW;  F255B2ACC44EBA74 CRC64;
     MELPDPVRQR LGNFSRTVFS DSNRTGPEYN EGPDNEMVSS LALQMSLYFN TYFFPLWWVS
     SIMMLQMKYS ILPDYYKFIV VTIIILITLI EAIRLYLGYM GNLQEKVPEL AGFWLLSLLL
     QLPLILFLLF NEGLTNLPLE KAVHIIFTIF LTFQVVSAFL TLRKMVNQLA TRFHLQDFDR
     LSASRGDMRR VRSCIEEI