TMM17_MOUSE
ID TMM17_MOUSE Reviewed; 198 AA.
AC Q8K0U3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transmembrane protein 17;
GN Name=Tmem17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION IN THE TECTONIC-LIKE COMPLEX, FUNCTION, AND SUBCELLULAR
RP LOCATION.
RX PubMed=22179047; DOI=10.1038/ncb2410;
RA Chih B., Liu P., Chinn Y., Chalouni C., Komuves L.G., Hass P.E.,
RA Sandoval W., Peterson A.S.;
RT "A ciliopathy complex at the transition zone protects the cilia as a
RT privileged membrane domain.";
RL Nat. Cell Biol. 14:61-72(2012).
CC -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC complex localized at the transition zone of primary cilia and acting as
CC a barrier that prevents diffusion of transmembrane proteins between the
CC cilia and plasma membranes. Required for ciliogenesis and sonic
CC hedgehog/SHH signaling. {ECO:0000269|PubMed:22179047}.
CC -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC {ECO:0000269|PubMed:22179047}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000269|PubMed:22179047}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:22179047}. Note=Localizes to the transition zone of
CC primary cilia.
CC -!- SIMILARITY: Belongs to the TMEM17 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL731818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030386; AAH30386.1; -; mRNA.
DR CCDS; CCDS24470.1; -.
DR RefSeq; NP_705824.1; NM_153596.3.
DR AlphaFoldDB; Q8K0U3; -.
DR CORUM; Q8K0U3; -.
DR IntAct; Q8K0U3; 4.
DR STRING; 10090.ENSMUSP00000051414; -.
DR GlyGen; Q8K0U3; 1 site.
DR PhosphoSitePlus; Q8K0U3; -.
DR PaxDb; Q8K0U3; -.
DR PeptideAtlas; Q8K0U3; -.
DR PRIDE; Q8K0U3; -.
DR ProteomicsDB; 259256; -.
DR Antibodypedia; 15953; 57 antibodies from 12 providers.
DR DNASU; 103765; -.
DR Ensembl; ENSMUST00000059319; ENSMUSP00000051414; ENSMUSG00000049904.
DR GeneID; 103765; -.
DR KEGG; mmu:103765; -.
DR UCSC; uc007iee.1; mouse.
DR CTD; 200728; -.
DR MGI; MGI:2144205; Tmem17.
DR VEuPathDB; HostDB:ENSMUSG00000049904; -.
DR eggNOG; KOG4694; Eukaryota.
DR GeneTree; ENSGT00940000153899; -.
DR HOGENOM; CLU_092836_0_0_1; -.
DR InParanoid; Q8K0U3; -.
DR OMA; YFFPFWW; -.
DR OrthoDB; 1544916at2759; -.
DR PhylomeDB; Q8K0U3; -.
DR TreeFam; TF323824; -.
DR BioGRID-ORCS; 103765; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Tmem17; mouse.
DR PRO; PR:Q8K0U3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8K0U3; protein.
DR Bgee; ENSMUSG00000049904; Expressed in neural tube and 158 other tissues.
DR Genevisible; Q8K0U3; MM.
DR GO; GO:0060170; C:ciliary membrane; IDA:UniProtKB.
DR GO; GO:0035869; C:ciliary transition zone; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0036038; C:MKS complex; IDA:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR GO; GO:1905515; P:non-motile cilium assembly; ISO:MGI.
DR GO; GO:0007224; P:smoothened signaling pathway; IMP:UniProtKB.
DR InterPro; IPR019184; Uncharacterised_TM-17.
DR PANTHER; PTHR13531; PTHR13531; 1.
DR Pfam; PF09799; Transmemb_17; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..198
FT /note="Transmembrane protein 17"
FT /id="PRO_0000255261"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 198 AA; 22623 MW; 579F21284F6AE18B CRC64;
MELPDPVRQR LSNLSLTVFG DSSRTGPESS DAADNEMVSS LALQMSLYFN SYFFPLWWVS
CIVMLHLKYS ILPDYYKFIV VTVVILITLI EAIRLYLGCM GNLQEKVPEL AGFWLLSLLL
QLPLILFLLL NDGLRNLPLE KAIHIIFTIF LTFQVISAFL TLKKMVNQLA ARFHLQDFDQ
LSSSSAAVRR VRQCTEEL
