ID   TMM17_RAT               Reviewed;         198 AA.
AC   Q5HZE5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Transmembrane protein 17;
GN   Name=Tmem17;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transmembrane component of the tectonic-like complex, a
CC       complex localized at the transition zone of primary cilia and acting as
CC       a barrier that prevents diffusion of transmembrane proteins between the
CC       cilia and plasma membranes. Required for ciliogenesis and sonic
CC       hedgehog/SHH signaling (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the
CC       transition zone of primary cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM17 family. {ECO:0000305}.
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DR   EMBL; BC089059; AAH89059.1; -; mRNA.
DR   RefSeq; NP_001010961.1; NM_001010961.1.
DR   RefSeq; XP_017454809.1; XM_017599320.1.
DR   RefSeq; XP_017454810.1; XM_017599321.1.
DR   AlphaFoldDB; Q5HZE5; -.
DR   STRING; 10116.ENSRNOP00000012224; -.
DR   GlyGen; Q5HZE5; 1 site.
DR   PaxDb; Q5HZE5; -.
DR   Ensembl; ENSRNOT00000012224; ENSRNOP00000012224; ENSRNOG00000009220.
DR   GeneID; 360985; -.
DR   KEGG; rno:360985; -.
DR   UCSC; RGD:1310566; rat.
DR   CTD; 200728; -.
DR   RGD; 1310566; Tmem17.
DR   eggNOG; KOG4694; Eukaryota.
DR   GeneTree; ENSGT00940000153899; -.
DR   HOGENOM; CLU_092836_0_0_1; -.
DR   InParanoid; Q5HZE5; -.
DR   OMA; YFFPFWW; -.
DR   OrthoDB; 1544916at2759; -.
DR   PhylomeDB; Q5HZE5; -.
DR   TreeFam; TF323824; -.
DR   PRO; PR:Q5HZE5; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000009220; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; Q5HZE5; RN.
DR   GO; GO:0060170; C:ciliary membrane; ISS:UniProtKB.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0036038; C:MKS complex; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019184; Uncharacterised_TM-17.
DR   PANTHER; PTHR13531; PTHR13531; 1.
DR   Pfam; PF09799; Transmemb_17; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..198
FT                   /note="Transmembrane protein 17"
FT                   /id="PRO_0000255262"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        13
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  22555 MW;  5640DFA8C44FA164 CRC64;
     MELPDPVRQR LSNLSLTMFG DSSRTGPESS EAADNEMVSS LPLQMSLYFN SYFFPLWWVS
     CIVMLHLKYS VLPDYYKFIV ITVVILITLI EAIRLYLGCM GNLQEKVPEL AGFWLLSLLL
     QLPLLLFLLL NEGLKNLPLE KAIHSIFTVF LTFQVISAFL TLKKMVNQLA ARFHLQDFDQ
     LSASSATGRR ARQSSEEL