TMM18_BOVIN
ID TMM18_BOVIN Reviewed; 139 AA.
AC Q3SZ36;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Transmembrane protein 18;
GN Name=TMEM18;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription repressor. Sequence-specific ssDNA and dsDNA
CC binding protein, with preference for GCT end CTG repeats. Cell
CC migration modulator which enhances the glioma-specific migration
CC ability of neural stem cells (NSC) and neural precursor cells (NPC) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms homooligomers, independently of the DNA-binding domain.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B42}. Nucleus
CC membrane {ECO:0000250|UniProtKB:Q96B42}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM18 family. {ECO:0000305}.
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DR EMBL; BC103183; AAI03184.1; -; mRNA.
DR RefSeq; NP_001029965.1; NM_001034793.1.
DR AlphaFoldDB; Q3SZ36; -.
DR STRING; 9913.ENSBTAP00000029309; -.
DR PaxDb; Q3SZ36; -.
DR Ensembl; ENSBTAT00000083368; ENSBTAP00000060679; ENSBTAG00000050718.
DR GeneID; 616554; -.
DR KEGG; bta:616554; -.
DR CTD; 129787; -.
DR VEuPathDB; HostDB:ENSBTAG00000050718; -.
DR VGNC; VGNC:36006; TMEM18.
DR eggNOG; ENOG502RZ4T; Eukaryota.
DR GeneTree; ENSGT00390000015191; -.
DR HOGENOM; CLU_101161_1_1_1; -.
DR InParanoid; Q3SZ36; -.
DR OMA; IVVMWVR; -.
DR OrthoDB; 1575793at2759; -.
DR TreeFam; TF324883; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000050718; Expressed in floor plate of diencephalon and 100 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR InterPro; IPR026721; TMEM18.
DR Pfam; PF14770; TMEM18; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; DNA-binding; Membrane; Nucleus; Reference proteome;
KW Transcription; Transmembrane; Transmembrane helix.
FT CHAIN 1..139
FT /note="Transmembrane protein 18"
FT /id="PRO_0000284368"
FT TOPO_DOM 1..25
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..52
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..91
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..139
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT REGION 113..139
FT /note="DNA-binding"
FT /evidence="ECO:0000250"
FT COILED 116..139
FT /evidence="ECO:0000255"
FT MOTIF 130..138
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
SQ SEQUENCE 139 AA; 16053 MW; 9634460667CAF21A CRC64;
MPSAFSVSRF PVSIPAVITQ TDWTEPWLVG LAGFHVLCLL LTCFSSQRYR LQVGHFLCLV
TLVYCAEYIN EVAAMNWRLF SKHQYFDSRG MFISLVFSAP LLLNALVIVV LWVRKTLVVM
TDLRSLREQR RARARPKEE
