TMM18_CHICK
ID TMM18_CHICK Reviewed; 142 AA.
AC Q5F410;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Transmembrane protein 18;
GN Name=TMEM18; ORFNames=RCJMB04_3n22;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q96B42};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM18 family. {ECO:0000305}.
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DR EMBL; AJ851490; CAH65124.1; -; mRNA.
DR RefSeq; NP_001012716.1; NM_001012698.1.
DR AlphaFoldDB; Q5F410; -.
DR STRING; 9031.ENSGALP00000043187; -.
DR PaxDb; Q5F410; -.
DR Ensembl; ENSGALT00000045991; ENSGALP00000043187; ENSGALG00000028744.
DR GeneID; 421911; -.
DR KEGG; gga:421911; -.
DR CTD; 129787; -.
DR VEuPathDB; HostDB:geneid_421911; -.
DR eggNOG; ENOG502S2NZ; Eukaryota.
DR GeneTree; ENSGT00390000015191; -.
DR HOGENOM; CLU_101161_1_1_1; -.
DR InParanoid; Q5F410; -.
DR OMA; IVVMWVR; -.
DR OrthoDB; 1575793at2759; -.
DR PhylomeDB; Q5F410; -.
DR TreeFam; TF324883; -.
DR PRO; PR:Q5F410; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000028744; Expressed in spermatid and 14 other tissues.
DR ExpressionAtlas; Q5F410; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR026721; TMEM18.
DR Pfam; PF14770; TMEM18; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; DNA-binding; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..142
FT /note="Transmembrane protein 18"
FT /id="PRO_0000284372"
FT TOPO_DOM 1..29
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..56
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..93
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..142
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT REGION 115..142
FT /note="DNA-binding"
FT /evidence="ECO:0000250"
FT COILED 120..142
FT /evidence="ECO:0000255"
SQ SEQUENCE 142 AA; 16469 MW; EB55F6CC51376F1A CRC64;
MRSVAVAMEQ PLHGPPGLST ILARTDWAEP WLLGLAGFHV LCFLLTCFSF QHYRVQIGHF
LCMVCLVYCA EYINELAAMN WRLFSKYQYF DSRGMFISLV FSAPLLVNTI IIVVNWVYRT
LNVMTELKTL QQRIKAEKDK KK
