ID   TMM18_DANRE             Reviewed;         152 AA.
AC   Q641M3;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Transmembrane protein 18;
GN   Name=tmem18; ORFNames=zgc:101011;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q96B42};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM18 family. {ECO:0000305}.
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DR   EMBL; BC082297; AAH82297.1; -; mRNA.
DR   RefSeq; NP_001005601.1; NM_001005601.2.
DR   AlphaFoldDB; Q641M3; -.
DR   STRING; 7955.ENSDARP00000053309; -.
DR   PaxDb; Q641M3; -.
DR   Ensembl; ENSDART00000053310; ENSDARP00000053309; ENSDARG00000036704.
DR   GeneID; 449559; -.
DR   KEGG; dre:449559; -.
DR   CTD; 129787; -.
DR   ZFIN; ZDB-GENE-040927-26; tmem18.
DR   eggNOG; ENOG502RZ4T; Eukaryota.
DR   GeneTree; ENSGT00390000015191; -.
DR   HOGENOM; CLU_101161_1_1_1; -.
DR   InParanoid; Q641M3; -.
DR   OMA; IVVMWVR; -.
DR   OrthoDB; 1575793at2759; -.
DR   PhylomeDB; Q641M3; -.
DR   TreeFam; TF324883; -.
DR   PRO; PR:Q641M3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000036704; Expressed in pharyngeal gill and 27 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR026721; TMEM18.
DR   Pfam; PF14770; TMEM18; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..152
FT                   /note="Transmembrane protein 18"
FT                   /id="PRO_0000284373"
FT   TOPO_DOM        1..36
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..63
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..102
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..152
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   REGION          124..152
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   COILED          129..152
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   152 AA;  17817 MW;  0D810BE9D4BA090B CRC64;
     MTASNTKNAS AIPIDKFSNV RITSIWTFLQ SVDWSEPWLM ALLAFHVFCF AFTLLSCKYY
     RIQICHFLLM VAMVYSAEYL NELAAMNWRS FSKFQYFDSK GMFISLVYSV PLLLNTVIIV
     AVWVWRTFST MTELKILQLK RKAARENHKK TQ