TMM18_MOUSE
ID TMM18_MOUSE Reviewed; 140 AA.
AC Q3TUD9; Q8CID7;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Transmembrane protein 18;
GN Name=Tmem18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Dendritic cell, Embryonic head, and Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcription repressor. Sequence-specific ssDNA and dsDNA
CC binding protein, with preference for GCT end CTG repeats. Cell
CC migration modulator which enhances the glioma-specific migration
CC ability of neural stem cells (NSC) and neural precursor cells (NPC) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms homooligomers, independently of the DNA-binding domain.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B42}. Nucleus
CC membrane {ECO:0000250|UniProtKB:Q96B42}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM18 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH24093.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK133493; BAE21685.1; -; mRNA.
DR EMBL; AK160817; BAE36032.1; -; mRNA.
DR EMBL; AK166323; BAE38705.1; -; mRNA.
DR EMBL; AK170496; BAE41835.1; -; mRNA.
DR EMBL; BC024093; AAH24093.3; ALT_INIT; mRNA.
DR CCDS; CCDS49043.1; -.
DR RefSeq; NP_742046.2; NM_172049.2.
DR AlphaFoldDB; Q3TUD9; -.
DR STRING; 10090.ENSMUSP00000050729; -.
DR PhosphoSitePlus; Q3TUD9; -.
DR PaxDb; Q3TUD9; -.
DR PRIDE; Q3TUD9; -.
DR ProteomicsDB; 259257; -.
DR Antibodypedia; 26187; 88 antibodies from 23 providers.
DR DNASU; 211986; -.
DR Ensembl; ENSMUST00000057151; ENSMUSP00000050729; ENSMUSG00000043061.
DR GeneID; 211986; -.
DR KEGG; mmu:211986; -.
DR UCSC; uc007ngu.2; mouse.
DR CTD; 129787; -.
DR MGI; MGI:2387176; Tmem18.
DR VEuPathDB; HostDB:ENSMUSG00000043061; -.
DR eggNOG; ENOG502RZ4T; Eukaryota.
DR GeneTree; ENSGT00390000015191; -.
DR HOGENOM; CLU_101161_1_1_1; -.
DR InParanoid; Q3TUD9; -.
DR OMA; IVVMWVR; -.
DR OrthoDB; 1575793at2759; -.
DR PhylomeDB; Q3TUD9; -.
DR TreeFam; TF324883; -.
DR BioGRID-ORCS; 211986; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q3TUD9; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q3TUD9; protein.
DR Bgee; ENSMUSG00000043061; Expressed in spermatocyte and 218 other tissues.
DR Genevisible; Q3TUD9; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR InterPro; IPR026721; TMEM18.
DR Pfam; PF14770; TMEM18; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; DNA-binding; Membrane; Nucleus; Reference proteome;
KW Transcription; Transmembrane; Transmembrane helix.
FT CHAIN 1..140
FT /note="Transmembrane protein 18"
FT /id="PRO_0000284370"
FT TOPO_DOM 1..25
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..52
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..91
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..140
FT /note="Nuclear"
FT /evidence="ECO:0000255"
FT REGION 113..140
FT /note="DNA-binding"
FT /evidence="ECO:0000250"
FT COILED 118..140
FT /evidence="ECO:0000255"
FT MOTIF 130..138
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
SQ SEQUENCE 140 AA; 16526 MW; 7551A1A7BC82E9D6 CRC64;
MSSAYSVRSF PVSIPAVIME TDWTEPWLLG LLAFHLLCLL LTCFSSQRYK LQIGHFLCLV
VLVYSAEYIN EVAAVNWRLF SKYQYFDSRG MFISLVFSAP LLFNAMLIVI MWVRKTLTVM
TDLKTLQEER KERRRRRKEE
