ID   TMM18_RAT               Reviewed;         140 AA.
AC   Q6DGF8;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Transmembrane protein 18;
GN   Name=Tmem18;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=18559506; DOI=10.1158/0008-5472.can-07-5291;
RA   Jurvansuu J., Zhao Y., Leung D.S., Boulaire J., Yu Y.H., Ahmed S., Wang S.;
RT   "Transmembrane protein 18 enhances the tropism of neural stem cells for
RT   glioma cells.";
RL   Cancer Res. 68:4614-4622(2008).
CC   -!- FUNCTION: Transcription repressor. Sequence-specific ssDNA and dsDNA
CC       binding protein, with preference for GCT end CTG repeats (By
CC       similarity). Cell migration modulator which enhances the glioma-
CC       specific migration ability of neural stem cells (NSC) and neural
CC       precursor cells (NPC). {ECO:0000250, ECO:0000269|PubMed:18559506}.
CC   -!- SUBUNIT: Forms homooligomers, independently of the DNA-binding domain.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B42}. Nucleus
CC       membrane {ECO:0000250|UniProtKB:Q96B42}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM18 family. {ECO:0000305}.
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DR   EMBL; BC076388; AAH76388.1; -; mRNA.
DR   RefSeq; NP_001007749.1; NM_001007748.1.
DR   AlphaFoldDB; Q6DGF8; -.
DR   STRING; 10116.ENSRNOP00000006836; -.
DR   PaxDb; Q6DGF8; -.
DR   Ensembl; ENSRNOT00000006836; ENSRNOP00000006836; ENSRNOG00000005144.
DR   GeneID; 362722; -.
DR   KEGG; rno:362722; -.
DR   UCSC; RGD:1359389; rat.
DR   CTD; 129787; -.
DR   RGD; 1359389; Tmem18.
DR   eggNOG; ENOG502RZ4T; Eukaryota.
DR   GeneTree; ENSGT00390000015191; -.
DR   HOGENOM; CLU_101161_1_1_1; -.
DR   InParanoid; Q6DGF8; -.
DR   OMA; IVVMWVR; -.
DR   OrthoDB; 1575793at2759; -.
DR   PhylomeDB; Q6DGF8; -.
DR   TreeFam; TF324883; -.
DR   PRO; PR:Q6DGF8; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000005144; Expressed in stomach and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016477; P:cell migration; IDA:UniProtKB.
DR   InterPro; IPR026721; TMEM18.
DR   Pfam; PF14770; TMEM18; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; DNA-binding; Membrane; Nucleus; Reference proteome;
KW   Transcription; Transmembrane; Transmembrane helix.
FT   CHAIN           1..140
FT                   /note="Transmembrane protein 18"
FT                   /id="PRO_0000284371"
FT   TOPO_DOM        1..25
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..52
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..91
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        113..140
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   REGION          113..140
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   COILED          117..140
FT                   /evidence="ECO:0000255"
FT   MOTIF           130..138
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   140 AA;  16548 MW;  96AA1819BC7BDE8B CRC64;
     MASPYSVRVF PVSIPAVIME TDWTEPWLLG LLAFHLLCLL LTCFSAQRYK LQIGHFLCLV
     VLVYCAEYIN EVAAMNWRLF AKYQYFDSRG MFISLVFSAP LLFNAMVIVI MWVRKTLTVM
     SDLKNLQERR KERKRRRKEE