ID   TMM18_XENTR             Reviewed;         136 AA.
AC   Q28GF5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Transmembrane protein 18;
GN   Name=tmem18; ORFNames=TEgg098f11.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q96B42};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM18 family. {ECO:0000305}.
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DR   EMBL; CR761408; CAJ82209.1; -; mRNA.
DR   RefSeq; NP_001016335.1; NM_001016335.2.
DR   AlphaFoldDB; Q28GF5; -.
DR   STRING; 8364.ENSXETP00000058106; -.
DR   PaxDb; Q28GF5; -.
DR   GeneID; 549089; -.
DR   KEGG; xtr:549089; -.
DR   CTD; 129787; -.
DR   Xenbase; XB-GENE-5729343; tmem18.
DR   eggNOG; ENOG502S2NZ; Eukaryota.
DR   InParanoid; Q28GF5; -.
DR   OrthoDB; 1575793at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000037122; Expressed in ovary and 12 other tissues.
DR   ExpressionAtlas; Q28GF5; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR026721; TMEM18.
DR   Pfam; PF14770; TMEM18; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..136
FT                   /note="Transmembrane protein 18"
FT                   /id="PRO_0000284375"
FT   TOPO_DOM        1..20
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..43
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..84
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106
FT                   /note="Nuclear"
FT                   /evidence="ECO:0000255"
FT   REGION          106
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   COILED          112..136
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   136 AA;  15995 MW;  B5CBAC493582547D CRC64;
     MAEDPGLWTL LERAPIDWKE PWLIGLAVFH ILCLIVTYVS FKSYPLQICH FLLMVVLVSC
     AEYINEFAAM HWRSYSKQQY FDSSGMFISL AFSAPLLCNT IIIVVHWVYK TLCVMTELKT
     LQQKRKESRE KRKKKE