TMM19_HUMAN
ID TMM19_HUMAN Reviewed; 336 AA.
AC Q96HH6; B2RDL2; Q53FY3; Q9NV41;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Transmembrane protein 19;
GN Name=TMEM19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Ovarian carcinoma, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96HH6; Q6Q788: APOA5; NbExp=3; IntAct=EBI-741829, EBI-3936819;
CC Q96HH6; Q13520: AQP6; NbExp=3; IntAct=EBI-741829, EBI-13059134;
CC Q96HH6; J3KQ12: BSCL2; NbExp=6; IntAct=EBI-741829, EBI-11532900;
CC Q96HH6; Q96G97: BSCL2; NbExp=4; IntAct=EBI-741829, EBI-741806;
CC Q96HH6; Q96G97-4: BSCL2; NbExp=4; IntAct=EBI-741829, EBI-10178113;
CC Q96HH6; Q8IYJ2-2: C10orf67; NbExp=3; IntAct=EBI-741829, EBI-13381098;
CC Q96HH6; P09693: CD3G; NbExp=3; IntAct=EBI-741829, EBI-3862428;
CC Q96HH6; P11912: CD79A; NbExp=3; IntAct=EBI-741829, EBI-7797864;
CC Q96HH6; P34972: CNR2; NbExp=3; IntAct=EBI-741829, EBI-2835940;
CC Q96HH6; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-741829, EBI-18013275;
CC Q96HH6; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-741829, EBI-6942903;
CC Q96HH6; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-741829, EBI-18535450;
CC Q96HH6; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-741829, EBI-18938272;
CC Q96HH6; P08034: GJB1; NbExp=3; IntAct=EBI-741829, EBI-17565645;
CC Q96HH6; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-741829, EBI-3917143;
CC Q96HH6; O15529: GPR42; NbExp=3; IntAct=EBI-741829, EBI-18076404;
CC Q96HH6; Q9NZD1: GPRC5D; NbExp=3; IntAct=EBI-741829, EBI-13067820;
CC Q96HH6; Q8TED1: GPX8; NbExp=3; IntAct=EBI-741829, EBI-11721746;
CC Q96HH6; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-741829, EBI-18053395;
CC Q96HH6; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-741829, EBI-749265;
CC Q96HH6; Q96B96: LDAF1; NbExp=3; IntAct=EBI-741829, EBI-7055862;
CC Q96HH6; O95214: LEPROTL1; NbExp=3; IntAct=EBI-741829, EBI-750776;
CC Q96HH6; Q16553: LY6E; NbExp=3; IntAct=EBI-741829, EBI-18234679;
CC Q96HH6; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-741829, EBI-373355;
CC Q96HH6; O15173: PGRMC2; NbExp=3; IntAct=EBI-741829, EBI-1050125;
CC Q96HH6; P57054: PIGP; NbExp=3; IntAct=EBI-741829, EBI-17630288;
CC Q96HH6; O14684: PTGES; NbExp=3; IntAct=EBI-741829, EBI-11161398;
CC Q96HH6; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-741829, EBI-7545592;
CC Q96HH6; Q96GF1: RNF185; NbExp=3; IntAct=EBI-741829, EBI-2340249;
CC Q96HH6; A2A2V5: SERTM1; NbExp=3; IntAct=EBI-741829, EBI-17284533;
CC Q96HH6; P30825: SLC7A1; NbExp=3; IntAct=EBI-741829, EBI-4289564;
CC Q96HH6; Q92537: SUSD6; NbExp=3; IntAct=EBI-741829, EBI-2866213;
CC Q96HH6; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-741829, EBI-19027521;
CC Q96HH6; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-741829, EBI-12947623;
CC Q96HH6; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-741829, EBI-7238458;
CC Q96HH6; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-741829, EBI-8638294;
CC Q96HH6; Q9NWC5: TMEM45A; NbExp=3; IntAct=EBI-741829, EBI-10823938;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96HH6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96HH6-2; Sequence=VSP_024659, VSP_024660;
CC -!- SIMILARITY: Belongs to the TMEM19 family. {ECO:0000305}.
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DR EMBL; AK001798; BAA91918.1; -; mRNA.
DR EMBL; AK223148; BAD96868.1; -; mRNA.
DR EMBL; AK315587; BAG37959.1; -; mRNA.
DR EMBL; CH471054; EAW97266.1; -; Genomic_DNA.
DR EMBL; BC008596; AAH08596.1; -; mRNA.
DR CCDS; CCDS9002.1; -. [Q96HH6-1]
DR RefSeq; NP_060749.2; NM_018279.3. [Q96HH6-1]
DR AlphaFoldDB; Q96HH6; -.
DR BioGRID; 120555; 41.
DR IntAct; Q96HH6; 38.
DR MINT; Q96HH6; -.
DR STRING; 9606.ENSP00000266673; -.
DR iPTMnet; Q96HH6; -.
DR PhosphoSitePlus; Q96HH6; -.
DR BioMuta; TMEM19; -.
DR DMDM; 74731932; -.
DR MassIVE; Q96HH6; -.
DR MaxQB; Q96HH6; -.
DR PaxDb; Q96HH6; -.
DR PeptideAtlas; Q96HH6; -.
DR PRIDE; Q96HH6; -.
DR ProteomicsDB; 76747; -. [Q96HH6-1]
DR ProteomicsDB; 76748; -. [Q96HH6-2]
DR Antibodypedia; 17095; 39 antibodies from 11 providers.
DR DNASU; 55266; -.
DR Ensembl; ENST00000266673.10; ENSP00000266673.5; ENSG00000139291.14. [Q96HH6-1]
DR Ensembl; ENST00000549735.5; ENSP00000449955.1; ENSG00000139291.14. [Q96HH6-2]
DR GeneID; 55266; -.
DR KEGG; hsa:55266; -.
DR MANE-Select; ENST00000266673.10; ENSP00000266673.5; NM_018279.4; NP_060749.2.
DR UCSC; uc001sws.4; human. [Q96HH6-1]
DR CTD; 55266; -.
DR DisGeNET; 55266; -.
DR GeneCards; TMEM19; -.
DR HGNC; HGNC:25605; TMEM19.
DR HPA; ENSG00000139291; Low tissue specificity.
DR neXtProt; NX_Q96HH6; -.
DR OpenTargets; ENSG00000139291; -.
DR PharmGKB; PA134909388; -.
DR VEuPathDB; HostDB:ENSG00000139291; -.
DR eggNOG; KOG4491; Eukaryota.
DR GeneTree; ENSGT00390000017998; -.
DR HOGENOM; CLU_036918_3_1_1; -.
DR InParanoid; Q96HH6; -.
DR OMA; VISPWRW; -.
DR PhylomeDB; Q96HH6; -.
DR TreeFam; TF300063; -.
DR PathwayCommons; Q96HH6; -.
DR SignaLink; Q96HH6; -.
DR BioGRID-ORCS; 55266; 8 hits in 1081 CRISPR screens.
DR GenomeRNAi; 55266; -.
DR Pharos; Q96HH6; Tdark.
DR PRO; PR:Q96HH6; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q96HH6; protein.
DR Bgee; ENSG00000139291; Expressed in ileal mucosa and 184 other tissues.
DR ExpressionAtlas; Q96HH6; baseline and differential.
DR Genevisible; Q96HH6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR002794; DUF92_TMEM19.
DR PANTHER; PTHR13353; PTHR13353; 1.
DR Pfam; PF01940; DUF92; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..336
FT /note="Transmembrane protein 19"
FT /id="PRO_0000284794"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 284..298
FT /note="LDESTGMVVNSPTNK -> KNIPSFLQLIGMLKK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024659"
FT VAR_SEQ 299..336
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024660"
FT CONFLICT 58
FT /note="V -> A (in Ref. 1; BAA91918)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="V -> L (in Ref. 2; BAD96868)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="A -> V (in Ref. 2; BAD96868)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 36392 MW; 95DCD6FAEED621E6 CRC64;
MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS PWRWLFSVVV
PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL LMFFLSSSKL TKWKGEVKKR
LDSEYKEGGQ RNWVQVFCNG AVPTELALLY MIENGPGEIP VDFSKQYSAS WMCLSLLAAL
ACSAGDTWAS EVGPVLSKSS PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT
QLIFVNDLDI SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR
HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG
