TMM19_MOUSE
ID TMM19_MOUSE Reviewed; 336 AA.
AC Q91W52; Q3UU09; Q8BY23; Q8BZK7;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transmembrane protein 19;
GN Name=Tmem19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, Diencephalon, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91W52-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91W52-2; Sequence=VSP_024661;
CC -!- SIMILARITY: Belongs to the TMEM19 family. {ECO:0000305}.
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DR EMBL; AK034298; BAC28663.1; -; mRNA.
DR EMBL; AK042426; BAC31256.1; -; mRNA.
DR EMBL; AK138931; BAE23820.1; -; mRNA.
DR EMBL; AK155275; BAE33158.1; -; mRNA.
DR EMBL; AK170143; BAE41594.1; -; mRNA.
DR EMBL; AK171087; BAE42240.1; -; mRNA.
DR EMBL; BC016895; AAH16895.1; -; mRNA.
DR CCDS; CCDS24178.1; -. [Q91W52-1]
DR CCDS; CCDS88087.1; -. [Q91W52-2]
DR RefSeq; NP_598444.1; NM_133683.3. [Q91W52-1]
DR RefSeq; XP_006514038.1; XM_006513975.1.
DR RefSeq; XP_006514039.1; XM_006513976.1.
DR RefSeq; XP_017169556.1; XM_017314067.1.
DR AlphaFoldDB; Q91W52; -.
DR BioGRID; 212031; 1.
DR STRING; 10090.ENSMUSP00000089808; -.
DR PhosphoSitePlus; Q91W52; -.
DR EPD; Q91W52; -.
DR jPOST; Q91W52; -.
DR MaxQB; Q91W52; -.
DR PaxDb; Q91W52; -.
DR PeptideAtlas; Q91W52; -.
DR PRIDE; Q91W52; -.
DR ProteomicsDB; 259580; -. [Q91W52-1]
DR ProteomicsDB; 259581; -. [Q91W52-2]
DR Antibodypedia; 17095; 39 antibodies from 11 providers.
DR DNASU; 67226; -.
DR Ensembl; ENSMUST00000092170; ENSMUSP00000089808; ENSMUSG00000069520. [Q91W52-1]
DR Ensembl; ENSMUST00000217887; ENSMUSP00000151334; ENSMUSG00000069520. [Q91W52-2]
DR GeneID; 67226; -.
DR KEGG; mmu:67226; -.
DR UCSC; uc007hba.1; mouse. [Q91W52-1]
DR UCSC; uc007hbc.1; mouse. [Q91W52-2]
DR CTD; 55266; -.
DR MGI; MGI:1914476; Tmem19.
DR VEuPathDB; HostDB:ENSMUSG00000069520; -.
DR eggNOG; KOG4491; Eukaryota.
DR GeneTree; ENSGT00390000017998; -.
DR HOGENOM; CLU_036918_3_1_1; -.
DR InParanoid; Q91W52; -.
DR OMA; VISPWRW; -.
DR OrthoDB; 1476886at2759; -.
DR PhylomeDB; Q91W52; -.
DR TreeFam; TF300063; -.
DR BioGRID-ORCS; 67226; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem19; mouse.
DR PRO; PR:Q91W52; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q91W52; protein.
DR Bgee; ENSMUSG00000069520; Expressed in right kidney and 247 other tissues.
DR ExpressionAtlas; Q91W52; baseline and differential.
DR Genevisible; Q91W52; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR002794; DUF92_TMEM19.
DR PANTHER; PTHR13353; PTHR13353; 1.
DR Pfam; PF01940; DUF92; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..336
FT /note="Transmembrane protein 19"
FT /id="PRO_0000284795"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MLSIPPPQVLVALFSM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024661"
FT CONFLICT 182
FT /note="S -> G (in Ref. 1; BAE23820)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 36296 MW; 51A809EBEDE978ED CRC64;
MTDSDDTTCK RYIKMITNIV ILSLIICISL AFWIMSMTAS TYYGNFRPVS PWRWLFSVVV
PVVIACNGFK KKSLDHSGAL GGLVVGFILT IANFSFFTSL MTFFLSSSKL TKWRGNIKKQ
LDSEYKEGGQ RNWVQVFCNG AVPTELALLY MIENGPGEMP IDFSKQHTAS WMCLSLLAAL
ASSAGDTWAS EVAPVLSKSS PRLITTWEKV PVGTNGGVTA VGLASSLLGG TFVGLAYFLT
QLVFVNDLDI SAPQWPIIAF GGVAGLFGSL VDSFLGATMQ FSGLDERTGL VVSSPTQETK
HIAGKPILDN NAVNLFSSVL VALLLPTAAS GFWPRE
