TMM26_HUMAN
ID TMM26_HUMAN Reviewed; 368 AA.
AC Q6ZUK4; Q6ZVM0; Q8IVN9;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transmembrane protein 26;
GN Name=TMEM26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZUK4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZUK4-2; Sequence=VSP_019806, VSP_019807;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
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DR EMBL; AK125611; BAC86218.1; -; mRNA.
DR EMBL; CR749606; CAH18401.1; -; mRNA.
DR EMBL; AC068892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC042872; AAH42872.1; -; mRNA.
DR CCDS; CCDS41530.1; -. [Q6ZUK4-1]
DR RefSeq; NP_848600.2; NM_178505.7. [Q6ZUK4-1]
DR RefSeq; XP_011537753.1; XM_011539451.1. [Q6ZUK4-2]
DR AlphaFoldDB; Q6ZUK4; -.
DR STRING; 9606.ENSP00000382237; -.
DR TCDB; 9.B.422.1.1; the transmembrane protein-26 (tmem26) family.
DR GlyGen; Q6ZUK4; 1 site.
DR iPTMnet; Q6ZUK4; -.
DR PhosphoSitePlus; Q6ZUK4; -.
DR BioMuta; TMEM26; -.
DR DMDM; 74749674; -.
DR jPOST; Q6ZUK4; -.
DR MassIVE; Q6ZUK4; -.
DR PaxDb; Q6ZUK4; -.
DR PeptideAtlas; Q6ZUK4; -.
DR PRIDE; Q6ZUK4; -.
DR ProteomicsDB; 68337; -. [Q6ZUK4-1]
DR ProteomicsDB; 68338; -. [Q6ZUK4-2]
DR Antibodypedia; 3065; 37 antibodies from 12 providers.
DR DNASU; 219623; -.
DR Ensembl; ENST00000399298.8; ENSP00000382237.3; ENSG00000196932.12. [Q6ZUK4-1]
DR Ensembl; ENST00000488505.2; ENSP00000426071.1; ENSG00000196932.12. [Q6ZUK4-2]
DR Ensembl; ENST00000503886.5; ENSP00000425286.1; ENSG00000196932.12. [Q6ZUK4-1]
DR GeneID; 219623; -.
DR KEGG; hsa:219623; -.
DR MANE-Select; ENST00000399298.8; ENSP00000382237.3; NM_178505.8; NP_848600.2.
DR UCSC; uc001jlo.3; human. [Q6ZUK4-1]
DR CTD; 219623; -.
DR DisGeNET; 219623; -.
DR GeneCards; TMEM26; -.
DR HGNC; HGNC:28550; TMEM26.
DR HPA; ENSG00000196932; Tissue enhanced (lymphoid).
DR MIM; 617803; gene.
DR neXtProt; NX_Q6ZUK4; -.
DR OpenTargets; ENSG00000196932; -.
DR PharmGKB; PA134887276; -.
DR VEuPathDB; HostDB:ENSG00000196932; -.
DR eggNOG; KOG4610; Eukaryota.
DR GeneTree; ENSGT00390000014794; -.
DR HOGENOM; CLU_032511_0_0_1; -.
DR InParanoid; Q6ZUK4; -.
DR OMA; VQHIGCK; -.
DR OrthoDB; 1097257at2759; -.
DR PhylomeDB; Q6ZUK4; -.
DR TreeFam; TF314156; -.
DR PathwayCommons; Q6ZUK4; -.
DR BioGRID-ORCS; 219623; 12 hits in 1073 CRISPR screens.
DR ChiTaRS; TMEM26; human.
DR GenomeRNAi; 219623; -.
DR Pharos; Q6ZUK4; Tdark.
DR PRO; PR:Q6ZUK4; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q6ZUK4; protein.
DR Bgee; ENSG00000196932; Expressed in adrenal tissue and 95 other tissues.
DR ExpressionAtlas; Q6ZUK4; baseline and differential.
DR Genevisible; Q6ZUK4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019169; Transmembrane_26.
DR PANTHER; PTHR22168; PTHR22168; 1.
DR Pfam; PF09772; Tmem26; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..368
FT /note="Transmembrane protein 26"
FT /id="PRO_0000245865"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 324..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT VAR_SEQ 203..223
FT /note="NSPALVYAILVIWTWSMLQFP -> LCWKNSTNRRHTNPKWQLVLF (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019806"
FT VAR_SEQ 224..368
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019807"
SQ SEQUENCE 368 AA; 41672 MW; 2B1F82FEF0C1CCED CRC64;
MEGLVFLNAL ATRLLFLLHS LVGVWRVTEV KKEPRYWLLA LLNLLLFLET ALTLKFKRGR
GYKWFSPAIF LYLISIVPSL WLLELHHETQ YCSIQAEGTS QNTSRKEDFN QTLTSNEQTS
RADDLIETAK VFVNNLSTVC EKVWTLGLHQ TFLLMLIIGR WLLPIGGGIT RDQLSQLLLM
FVGTAADILE FTSETLEEQN VRNSPALVYA ILVIWTWSML QFPLDLAVQN VVCPVSVTER
GFPSLFFCQY SADLWNIGIS VFIQDGPFLV VRLILMTYFK VINQMLVFFA AKNFLVVVLQ
LYRLVVLALA VRASLRSQSE GLKGEHGCRA QTSESGPSQR DWQNESKEGL AIPLRGSPVT
SDDSHHTP
