TMM26_MOUSE
ID TMM26_MOUSE Reviewed; 366 AA.
AC Q3UP23; Q149T3; Q8BN94;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Transmembrane protein 26;
GN Name=Tmem26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK143866; BAE25574.1; -; mRNA.
DR EMBL; AK084351; BAC39167.1; -; mRNA.
DR EMBL; BC117503; AAI17504.1; -; mRNA.
DR CCDS; CCDS23906.1; -.
DR RefSeq; NP_808462.2; NM_177794.3.
DR AlphaFoldDB; Q3UP23; -.
DR BioGRID; 236485; 1.
DR STRING; 10090.ENSMUSP00000079789; -.
DR GlyGen; Q3UP23; 1 site.
DR iPTMnet; Q3UP23; -.
DR PhosphoSitePlus; Q3UP23; -.
DR PaxDb; Q3UP23; -.
DR PRIDE; Q3UP23; -.
DR ProteomicsDB; 259031; -.
DR Antibodypedia; 3065; 37 antibodies from 12 providers.
DR Ensembl; ENSMUST00000080995; ENSMUSP00000079789; ENSMUSG00000060044.
DR GeneID; 327766; -.
DR KEGG; mmu:327766; -.
DR UCSC; uc007fmm.2; mouse.
DR CTD; 219623; -.
DR MGI; MGI:2143537; Tmem26.
DR VEuPathDB; HostDB:ENSMUSG00000060044; -.
DR eggNOG; KOG4610; Eukaryota.
DR GeneTree; ENSGT00390000014794; -.
DR HOGENOM; CLU_032511_0_0_1; -.
DR InParanoid; Q3UP23; -.
DR OMA; VQHIGCK; -.
DR OrthoDB; 1097257at2759; -.
DR PhylomeDB; Q3UP23; -.
DR TreeFam; TF314156; -.
DR BioGRID-ORCS; 327766; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q3UP23; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q3UP23; protein.
DR Bgee; ENSMUSG00000060044; Expressed in dorsal pancreas and 135 other tissues.
DR ExpressionAtlas; Q3UP23; baseline and differential.
DR Genevisible; Q3UP23; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019169; Transmembrane_26.
DR PANTHER; PTHR22168; PTHR22168; 1.
DR Pfam; PF09772; Tmem26; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..366
FT /note="Transmembrane protein 26"
FT /id="PRO_0000245866"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 319..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 45
FT /note="L -> M (in Ref. 1; BAE25574)"
FT /evidence="ECO:0000305"
FT CONFLICT 49
FT /note="E -> D (in Ref. 1; BAC39167)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 366 AA; 41637 MW; BF62E559BB0EE534 CRC64;
MEGLVLLKAL VTRLLFLLHS LVAVWRVTWV KEEHRYWLLA LLNLLLVLET VLTLKFKRGR
GYKWLSPAIF VYLVNIMPSL WLLEMHHGNQ YCSTQSERMA QNFSRRGDVN QTLSSHRATN
GMGNILELAR GFVDNLSMVC EPVWTLGLHQ TLLLILIIGR WLLPIGGTIT RDQLSELLLM
FVGTAADILE FTTETLKENN VRTNPTLVSG ILVVWTWSML QFPLDLAVQL KLVCPASVKA
RGFLRVFLCQ YSADLWAIGL SFFIQDGPFL VVRLVLMIYF KVINHMLVFF AVKNSLVMAL
HFYRLVALIM ATRDFMRDHP ESPKPEHSGP DQPSESGPSE WEDASPEALP LRTSPVTSEE
SYPTTP
