TMM31_HUMAN
ID TMM31_HUMAN Reviewed; 168 AA.
AC Q5JXX7; Q8NHR4;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transmembrane protein 31;
GN Name=TMEM31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5JXX7; O43765: SGTA; NbExp=3; IntAct=EBI-10244617, EBI-347996;
CC Q5JXX7; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-10244617, EBI-741480;
CC Q5JXX7; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-10244617, EBI-10173939;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL049610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029575; AAH29575.1; -; mRNA.
DR CCDS; CCDS35359.1; -.
DR RefSeq; NP_872347.2; NM_182541.2.
DR AlphaFoldDB; Q5JXX7; -.
DR BioGRID; 128478; 197.
DR IntAct; Q5JXX7; 2.
DR STRING; 9606.ENSP00000316940; -.
DR TCDB; 9.B.356.1.1; the tmem31 (tmem31) family.
DR iPTMnet; Q5JXX7; -.
DR PhosphoSitePlus; Q5JXX7; -.
DR BioMuta; TMEM31; -.
DR MassIVE; Q5JXX7; -.
DR PaxDb; Q5JXX7; -.
DR PeptideAtlas; Q5JXX7; -.
DR PRIDE; Q5JXX7; -.
DR ProteomicsDB; 63478; -.
DR Antibodypedia; 65930; 28 antibodies from 5 providers.
DR DNASU; 203562; -.
DR Ensembl; ENST00000319560.7; ENSP00000316940.6; ENSG00000179363.7.
DR GeneID; 203562; -.
DR KEGG; hsa:203562; -.
DR MANE-Select; ENST00000319560.7; ENSP00000316940.6; NM_182541.2; NP_872347.2.
DR UCSC; uc004elh.4; human.
DR CTD; 203562; -.
DR DisGeNET; 203562; -.
DR GeneCards; TMEM31; -.
DR HGNC; HGNC:28601; TMEM31.
DR HPA; ENSG00000179363; Tissue enriched (testis).
DR neXtProt; NX_Q5JXX7; -.
DR OpenTargets; ENSG00000179363; -.
DR PharmGKB; PA134926659; -.
DR VEuPathDB; HostDB:ENSG00000179363; -.
DR eggNOG; ENOG502TM47; Eukaryota.
DR GeneTree; ENSGT00390000001638; -.
DR HOGENOM; CLU_136296_0_0_1; -.
DR InParanoid; Q5JXX7; -.
DR OMA; PIQWFAS; -.
DR OrthoDB; 614790at2759; -.
DR PhylomeDB; Q5JXX7; -.
DR TreeFam; TF353626; -.
DR PathwayCommons; Q5JXX7; -.
DR SignaLink; Q5JXX7; -.
DR BioGRID-ORCS; 203562; 10 hits in 660 CRISPR screens.
DR GenomeRNAi; 203562; -.
DR Pharos; Q5JXX7; Tdark.
DR PRO; PR:Q5JXX7; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5JXX7; protein.
DR Bgee; ENSG00000179363; Expressed in sperm and 103 other tissues.
DR ExpressionAtlas; Q5JXX7; baseline and differential.
DR Genevisible; Q5JXX7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..168
FT /note="Transmembrane protein 31"
FT /id="PRO_0000284800"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 154..155
FT /note="Missing (in Ref. 2; AAH29575)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 168 AA; 19813 MW; 7824918182ECAB48 CRC64;
MRLTEKSEGE QQLKPNNSNA PNEDQEEEIQ QSEQHTPARQ RTQRADTQPS RCRLPSRRTP
TTSSDRTINL LEVLPWPTEW IFNPYRLPAL FELYPEFLLV FKEAFHDISH CLKAQMEKIG
LPIILHLFAL STLYFYKFFL PTILSLSFFI LLVLLLLLFI IVFILIFF
