ID   TMM33_CAEEL             Reviewed;         271 AA.
AC   Q9XWV0;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Transmembrane protein 33 homolog;
GN   Name=npp-25 {ECO:0000312|WormBase:Y37D8A.17a};
GN   ORFNames=Y37D8A.17 {ECO:0000312|WormBase:Y37D8A.17a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PER33/POM33 family. {ECO:0000305}.
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DR   EMBL; BX284603; CAA21541.1; -; Genomic_DNA.
DR   PIR; T26640; T26640.
DR   RefSeq; NP_499684.1; NM_067283.1.
DR   AlphaFoldDB; Q9XWV0; -.
DR   SMR; Q9XWV0; -.
DR   BioGRID; 54250; 3.
DR   DIP; DIP-25499N; -.
DR   IntAct; Q9XWV0; 2.
DR   STRING; 6239.Y37D8A.17; -.
DR   EPD; Q9XWV0; -.
DR   PaxDb; Q9XWV0; -.
DR   PeptideAtlas; Q9XWV0; -.
DR   EnsemblMetazoa; Y37D8A.17a.1; Y37D8A.17a.1; WBGene00012555.
DR   GeneID; 189617; -.
DR   KEGG; cel:CELE_Y37D8A.17; -.
DR   UCSC; Y37D8A.17; c. elegans.
DR   CTD; 189617; -.
DR   WormBase; Y37D8A.17a; CE20221; WBGene00012555; npp-25.
DR   eggNOG; KOG4002; Eukaryota.
DR   GeneTree; ENSGT00390000011368; -.
DR   HOGENOM; CLU_071391_0_0_1; -.
DR   InParanoid; Q9XWV0; -.
DR   OMA; FFSIRPT; -.
DR   OrthoDB; 1360050at2759; -.
DR   PhylomeDB; Q9XWV0; -.
DR   PRO; PR:Q9XWV0; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00012555; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q9XWV0; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR   GO; GO:0061024; P:membrane organization; IBA:GO_Central.
DR   InterPro; IPR005344; TMEM33/Pom33.
DR   Pfam; PF03661; TMEM33_Pom33; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..271
FT                   /note="Transmembrane protein 33 homolog"
FT                   /id="PRO_0000220902"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  29615 MW;  231B67EA3A3D215B CRC64;
     MVEIVEEPDD HQSSSTGAGS SGSSSAPPPP PPPAYSSISQ YVSANTMECV LFAARVLTVF
     FALNYMIPFI GLVPAHSAYY KIFAASAATF ALRLHTRIQG QFALNAQFIQ RLIIEDSFHY
     LVYSVVFLMA APVSMAALPV TIYAALHACT FMTKILRETG HTSSIIPKLE QFTAHQTQNA
     LGIIACSEIF LVPLLVSLIF SGKGSLLLPF AYYRFLSLRY ASRRNPSTRQ AFAQMRGSLQ
     NVAMSSSCPR PISSLIYRAI DFISARAPPV M