ID   TMM33_DICDI             Reviewed;         290 AA.
AC   Q54ME7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Transmembrane protein 33 homolog;
GN   Name=tmem33; ORFNames=DDB_G0286009;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PER33/POM33 family. {ECO:0000305}.
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DR   EMBL; AAFI02000084; EAL64438.1; -; Genomic_DNA.
DR   RefSeq; XP_637942.1; XM_632850.1.
DR   AlphaFoldDB; Q54ME7; -.
DR   STRING; 44689.DDB0266865; -.
DR   TCDB; 1.I.1.1.5; the nuclear pore complex (npc) family.
DR   PaxDb; Q54ME7; -.
DR   PRIDE; Q54ME7; -.
DR   EnsemblProtists; EAL64438; EAL64438; DDB_G0286009.
DR   GeneID; 8625395; -.
DR   KEGG; ddi:DDB_G0286009; -.
DR   dictyBase; DDB_G0286009; tmem33.
DR   eggNOG; KOG4002; Eukaryota.
DR   HOGENOM; CLU_961163_0_0_1; -.
DR   InParanoid; Q54ME7; -.
DR   OMA; FFSIRPT; -.
DR   PhylomeDB; Q54ME7; -.
DR   PRO; PR:Q54ME7; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IBA:GO_Central.
DR   GO; GO:0061024; P:membrane organization; IBA:GO_Central.
DR   InterPro; IPR005344; TMEM33/Pom33.
DR   Pfam; PF03661; TMEM33_Pom33; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..290
FT                   /note="Transmembrane protein 33 homolog"
FT                   /id="PRO_0000345004"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   290 AA;  33485 MW;  2D006611D43AEB1A CRC64;
     MSSPKFDSYD WENDPNWKEF TGTSTSINKL KEEYFKKNID PNYKSSNNTT TQRPSTSSSS
     RTSSSSTSSP RATRAKPTFR RFLYGAWVIA QISVILFTLF YFISGNPYFF YKALLGATIA
     YSIPIFNTFE GRKPDRALAA QLVQDENAQF VFYCMIFYFF GSSSLVYLLP NFIYSFFHML
     KIVIPYTSSV PFIKNLLEKV NSTNAKAIDF AISVEINIVL IAFFGIFSSF SNILLVFIYF
     RYLKLRYQFS QKIKSKINEY SQMVDQLSAH PSCPTFIRNI IPKIKMVLSR