BTBD8_MOUSE
ID BTBD8_MOUSE Reviewed; 377 AA.
AC D3YUB6;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=BTB/POZ domain-containing protein 8;
GN Name=Btbd8; Synonyms=Gm16115;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5XKL5}.
CC Note=Localized to nucleus in fetal cells.
CC {ECO:0000250|UniProtKB:Q5XKL5}.
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DR EMBL; AC126598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC134411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001242920.1; NM_001255991.1.
DR AlphaFoldDB; D3YUB6; -.
DR SMR; D3YUB6; -.
DR STRING; 10090.ENSMUSP00000092119; -.
DR PaxDb; D3YUB6; -.
DR PRIDE; D3YUB6; -.
DR Ensembl; ENSMUST00000094541; ENSMUSP00000092119; ENSMUSG00000111375.
DR GeneID; 100503185; -.
DR UCSC; uc029vkf.1; mouse.
DR CTD; 284697; -.
DR MGI; MGI:3646208; Btbd8.
DR VEuPathDB; HostDB:ENSMUSG00000111375; -.
DR eggNOG; ENOG502S0TN; Eukaryota.
DR GeneTree; ENSGT00940000154382; -.
DR HOGENOM; CLU_062039_0_0_1; -.
DR InParanoid; D3YUB6; -.
DR OrthoDB; 761810at2759; -.
DR PhylomeDB; D3YUB6; -.
DR TreeFam; TF330633; -.
DR BioGRID-ORCS; 100503185; 2 hits in 72 CRISPR screens.
DR PRO; PR:D3YUB6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; D3YUB6; protein.
DR Bgee; ENSMUSG00000111375; Expressed in habenula and 201 other tissues.
DR ExpressionAtlas; D3YUB6; baseline and differential.
DR GO; GO:0030122; C:AP-2 adaptor complex; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR CDD; cd18490; BACK_BTBD8; 1.
DR Gene3D; 3.30.710.10; -; 2.
DR InterPro; IPR043225; BACK_BTBD8.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 2.
DR SMART; SM00225; BTB; 2.
DR SUPFAM; SSF54695; SSF54695; 2.
DR PROSITE; PS50097; BTB; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..377
FT /note="BTB/POZ domain-containing protein 8"
FT /id="PRO_0000416101"
FT DOMAIN 58..126
FT /note="BTB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 205..272
FT /note="BTB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REGION 13..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 41583 MW; 28EAA569083B79D2 CRC64;
MAHCGAGGAA PVALLSSPGH GRKGLPRKGP GERRRLKAAV SEQLSRDVLR LLREEIHTDT
ILSVSGSLFK VHKAVLLARA PGFHSHIIEH TSSDLTNELV PVDGVEASEF KAFLQIVYSS
NKNIKNYEEE IVKKLKVGSL MPEKGPDVSF PRYRTSSDCF LGKGEIPEDI TGGGDCFISK
ADSDLEPASE LGGDLLKLYL SQHYPDIDIC VDGRSFRAHR AILSARSSYF AAMLSGCWAE
SSQECITLQG ITHVEMNVMM HFIYGGTLDF PEKANVGQIL NVADMYGLEG LREVAIYVLR
RDYCNFFQKP VPRTWASILE CLIIAHSVGV ESLFADCMNC IISHFARFWS ERSFANVPPE
IQKTCLSMQI QSLVSIV
