TMM42_HUMAN
ID TMM42_HUMAN Reviewed; 159 AA.
AC Q69YG0; Q8WUQ6;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transmembrane protein 42;
GN Name=TMEM42;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q69YG0; Q92482: AQP3; NbExp=3; IntAct=EBI-12038591, EBI-2808854;
CC Q69YG0; Q13520: AQP6; NbExp=3; IntAct=EBI-12038591, EBI-13059134;
CC Q69YG0; P11912: CD79A; NbExp=3; IntAct=EBI-12038591, EBI-7797864;
CC Q69YG0; Q86UW9: DTX2; NbExp=3; IntAct=EBI-12038591, EBI-740376;
CC Q69YG0; Q15125: EBP; NbExp=3; IntAct=EBI-12038591, EBI-3915253;
CC Q69YG0; Q92838: EDA; NbExp=3; IntAct=EBI-12038591, EBI-529425;
CC Q69YG0; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-12038591, EBI-18535450;
CC Q69YG0; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12038591, EBI-781551;
CC Q69YG0; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-12038591, EBI-18636064;
CC Q69YG0; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12038591, EBI-18304435;
CC Q69YG0; O00258: GET1; NbExp=3; IntAct=EBI-12038591, EBI-18908258;
CC Q69YG0; P48165: GJA8; NbExp=3; IntAct=EBI-12038591, EBI-17458373;
CC Q69YG0; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-12038591, EBI-13345167;
CC Q69YG0; Q8TED1: GPX8; NbExp=3; IntAct=EBI-12038591, EBI-11721746;
CC Q69YG0; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-12038591, EBI-1052304;
CC Q69YG0; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12038591, EBI-18053395;
CC Q69YG0; O95214: LEPROTL1; NbExp=3; IntAct=EBI-12038591, EBI-750776;
CC Q69YG0; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-12038591, EBI-2820517;
CC Q69YG0; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-12038591, EBI-11956541;
CC Q69YG0; Q15546: MMD; NbExp=3; IntAct=EBI-12038591, EBI-17873222;
CC Q69YG0; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-12038591, EBI-6163737;
CC Q69YG0; Q6IN84: MRM1; NbExp=3; IntAct=EBI-12038591, EBI-5454865;
CC Q69YG0; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-12038591, EBI-3923617;
CC Q69YG0; O14524-2: NEMP1; NbExp=3; IntAct=EBI-12038591, EBI-10969203;
CC Q69YG0; O75360: PROP1; NbExp=3; IntAct=EBI-12038591, EBI-9027467;
CC Q69YG0; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-12038591, EBI-712367;
CC Q69YG0; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-12038591, EBI-740343;
CC Q69YG0; Q9H902: REEP1; NbExp=3; IntAct=EBI-12038591, EBI-1644241;
CC Q69YG0; Q9BRK0: REEP2; NbExp=3; IntAct=EBI-12038591, EBI-11337973;
CC Q69YG0; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-12038591, EBI-10192441;
CC Q69YG0; Q8TEB9: RHBDD1; NbExp=3; IntAct=EBI-12038591, EBI-9916444;
CC Q69YG0; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-12038591, EBI-3920694;
CC Q69YG0; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12038591, EBI-17247926;
CC Q69YG0; Q9BY50: SEC11C; NbExp=3; IntAct=EBI-12038591, EBI-2855401;
CC Q69YG0; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-12038591, EBI-18037857;
CC Q69YG0; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-12038591, EBI-17595455;
CC Q69YG0; O95436-2: SLC34A2; NbExp=3; IntAct=EBI-12038591, EBI-12811757;
CC Q69YG0; Q96QK8: SMIM14; NbExp=3; IntAct=EBI-12038591, EBI-373430;
CC Q69YG0; Q8N434-2: SVOPL; NbExp=3; IntAct=EBI-12038591, EBI-23750686;
CC Q69YG0; O43711: TLX3; NbExp=3; IntAct=EBI-12038591, EBI-3939165;
CC Q69YG0; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-12038591, EBI-6448756;
CC Q69YG0; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-12038591, EBI-348587;
CC Q69YG0; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12038591, EBI-8638294;
CC Q69YG0; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12038591, EBI-10982110;
CC Q69YG0; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-12038591, EBI-11722971;
CC Q69YG0; Q96NL1: TMEM74; NbExp=3; IntAct=EBI-12038591, EBI-10292091;
CC Q69YG0; O95231: VENTX; NbExp=3; IntAct=EBI-12038591, EBI-10191303;
CC Q69YG0; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-12038591, EBI-12837904;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL834253; CAH10689.1; -; mRNA.
DR EMBL; BC019851; AAH19851.1; -; mRNA.
DR CCDS; CCDS2722.1; -.
DR RefSeq; NP_653239.1; NM_144638.2.
DR AlphaFoldDB; Q69YG0; -.
DR BioGRID; 126290; 54.
DR IntAct; Q69YG0; 49.
DR MINT; Q69YG0; -.
DR STRING; 9606.ENSP00000306564; -.
DR iPTMnet; Q69YG0; -.
DR PhosphoSitePlus; Q69YG0; -.
DR BioMuta; TMEM42; -.
DR DMDM; 145572734; -.
DR MassIVE; Q69YG0; -.
DR PaxDb; Q69YG0; -.
DR PeptideAtlas; Q69YG0; -.
DR PRIDE; Q69YG0; -.
DR ProteomicsDB; 66153; -.
DR Antibodypedia; 29508; 27 antibodies from 11 providers.
DR DNASU; 131616; -.
DR Ensembl; ENST00000302392.5; ENSP00000306564.4; ENSG00000169964.8.
DR Ensembl; ENST00000626748.2; ENSP00000486141.1; ENSG00000280516.4.
DR GeneID; 131616; -.
DR KEGG; hsa:131616; -.
DR MANE-Select; ENST00000302392.5; ENSP00000306564.4; NM_144638.3; NP_653239.1.
DR UCSC; uc003cnz.4; human.
DR CTD; 131616; -.
DR GeneCards; TMEM42; -.
DR HGNC; HGNC:28444; TMEM42.
DR HPA; ENSG00000169964; Low tissue specificity.
DR neXtProt; NX_Q69YG0; -.
DR OpenTargets; ENSG00000169964; -.
DR PharmGKB; PA134914008; -.
DR VEuPathDB; HostDB:ENSG00000169964; -.
DR eggNOG; ENOG502RY7R; Eukaryota.
DR GeneTree; ENSGT00390000012690; -.
DR HOGENOM; CLU_076687_2_0_1; -.
DR InParanoid; Q69YG0; -.
DR OMA; WTFLSKA; -.
DR OrthoDB; 1405877at2759; -.
DR PhylomeDB; Q69YG0; -.
DR TreeFam; TF336306; -.
DR PathwayCommons; Q69YG0; -.
DR SignaLink; Q69YG0; -.
DR BioGRID-ORCS; 131616; 14 hits in 1076 CRISPR screens.
DR ChiTaRS; TMEM42; human.
DR GenomeRNAi; 131616; -.
DR Pharos; Q69YG0; Tdark.
DR PRO; PR:Q69YG0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q69YG0; protein.
DR Bgee; ENSG00000169964; Expressed in C1 segment of cervical spinal cord and 95 other tissues.
DR Genevisible; Q69YG0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039632; TMEM42.
DR PANTHER; PTHR31965; PTHR31965; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..159
FT /note="Transmembrane protein 42"
FT /id="PRO_0000284495"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 65
FT /note="V -> VV (in Ref. 1; CAH10689)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 16991 MW; A8572BF4BC9CF44E CRC64;
MAERPGPPGG AVSATAYPDT PAEFPPHLQA GAMRRRFWGV FNCLCAGAFG ALAAASAKLA
FGSEVSMGLC VLGIIVMAST NSLMWTFFSR GLSFSMSSAI ASVTVTFSNI LSSAFLGYVL
YGECQEVLWW GGVFLILCGL TLIHRKLPPT WKPLPHKQQ
