TMM42_MOUSE
ID TMM42_MOUSE Reviewed; 157 AA.
AC Q9CR22;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transmembrane protein 42;
GN Name=Tmem42;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK002688; BAB22284.1; -; mRNA.
DR EMBL; AK012820; BAB28493.1; -; mRNA.
DR EMBL; BC049583; AAH49583.1; -; mRNA.
DR CCDS; CCDS23652.1; -.
DR RefSeq; NP_001158295.1; NM_001164823.1.
DR RefSeq; NP_079615.1; NM_025339.4.
DR RefSeq; XP_006512268.1; XM_006512205.1.
DR RefSeq; XP_006512269.1; XM_006512206.3.
DR AlphaFoldDB; Q9CR22; -.
DR STRING; 10090.ENSMUSP00000081784; -.
DR iPTMnet; Q9CR22; -.
DR PhosphoSitePlus; Q9CR22; -.
DR EPD; Q9CR22; -.
DR MaxQB; Q9CR22; -.
DR PaxDb; Q9CR22; -.
DR PRIDE; Q9CR22; -.
DR ProteomicsDB; 259034; -.
DR Antibodypedia; 29508; 27 antibodies from 11 providers.
DR DNASU; 66079; -.
DR Ensembl; ENSMUST00000084733; ENSMUSP00000081784; ENSMUSG00000066233.
DR GeneID; 66079; -.
DR KEGG; mmu:66079; -.
DR UCSC; uc009sfn.2; mouse.
DR CTD; 131616; -.
DR MGI; MGI:1277176; Tmem42.
DR VEuPathDB; HostDB:ENSMUSG00000066233; -.
DR eggNOG; ENOG502RY7R; Eukaryota.
DR GeneTree; ENSGT00390000012690; -.
DR HOGENOM; CLU_076687_2_0_1; -.
DR InParanoid; Q9CR22; -.
DR OMA; WTFLSKA; -.
DR OrthoDB; 1405877at2759; -.
DR PhylomeDB; Q9CR22; -.
DR TreeFam; TF336306; -.
DR BioGRID-ORCS; 66079; 2 hits in 70 CRISPR screens.
DR ChiTaRS; Tmem42; mouse.
DR PRO; PR:Q9CR22; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9CR22; protein.
DR Bgee; ENSMUSG00000066233; Expressed in interventricular septum and 244 other tissues.
DR ExpressionAtlas; Q9CR22; baseline and differential.
DR Genevisible; Q9CR22; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039632; TMEM42.
DR PANTHER; PTHR31965; PTHR31965; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..157
FT /note="Transmembrane protein 42"
FT /id="PRO_0000284496"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 157 AA; 16636 MW; 2FBD60615DB29A8A CRC64;
MAAGPQSSGA AVSAAAYPDS PVELPARLQK GAMRRRFWGV FNCLCAGAFG ALAAAAAKLA
FGSQVNIGLC VLGIVAMASA NSLMWTFFSR GLSFSMSSAI ASVTVTFSNI LCSAILGYLL
YGECQEILWW GGVFLILCGL TLIHRKFPPT WKESKEQ
