TMM43_DROME
ID TMM43_DROME Reviewed; 376 AA.
AC Q9VSB9; Q8SZN7;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Transmembrane protein 43 homolog;
GN ORFNames=CG8111;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM43 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF50506.1; -; Genomic_DNA.
DR EMBL; AY070625; AAL48096.1; -; mRNA.
DR RefSeq; NP_648162.2; NM_139905.4.
DR AlphaFoldDB; Q9VSB9; -.
DR BioGRID; 64308; 1.
DR IntAct; Q9VSB9; 1.
DR STRING; 7227.FBpp0076485; -.
DR PaxDb; Q9VSB9; -.
DR DNASU; 38881; -.
DR EnsemblMetazoa; FBtr0076770; FBpp0076485; FBgn0035825.
DR GeneID; 38881; -.
DR KEGG; dme:Dmel_CG8111; -.
DR UCSC; CG8111-RA; d. melanogaster.
DR FlyBase; FBgn0035825; CG8111.
DR VEuPathDB; VectorBase:FBgn0035825; -.
DR eggNOG; ENOG502QSR2; Eukaryota.
DR GeneTree; ENSGT00390000009671; -.
DR HOGENOM; CLU_042602_1_0_1; -.
DR InParanoid; Q9VSB9; -.
DR OMA; DWFPVVR; -.
DR OrthoDB; 866982at2759; -.
DR PhylomeDB; Q9VSB9; -.
DR BioGRID-ORCS; 38881; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38881; -.
DR PRO; PR:Q9VSB9; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035825; Expressed in embryonic/larval hemocyte (Drosophila) and 24 other tissues.
DR ExpressionAtlas; Q9VSB9; baseline and differential.
DR Genevisible; Q9VSB9; DM.
DR GO; GO:0005639; C:integral component of nuclear inner membrane; IBA:GO_Central.
DR GO; GO:0071763; P:nuclear membrane organization; IBA:GO_Central.
DR InterPro; IPR012430; TMEM43_fam.
DR PANTHER; PTHR13416; PTHR13416; 1.
DR Pfam; PF07787; TMEM43; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..376
FT /note="Transmembrane protein 43 homolog"
FT /id="PRO_0000284502"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 13
FT /note="P -> H (in Ref. 3; AAL48096)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 376 AA; 42773 MW; 900C5FA56C8FFC07 CRC64;
MASLSETLRS HWPIALFGVI LFVAGGTELY WNEGRAVHNM MALDEAHADI YSVRFTEEEQ
EVGLEGRIVH LSGPILVGEP LTEPDYNIQL LAVKLRRRVQ MYQWVEEAVE HNYGDSVGTT
HSDSRTYYYT REWRDKIVDS RNFYNRHGHT NPSHFPIESH VQVADAVFIG RYELGAEVKE
KFNNYQELTS DIRPEDSGVK LHLGIYYHTN DVFNPEVGDL RLLFSFAGME GEVFSVVGKL
SGNKLVPYIT SRGVPVLLVY PGGLSVQEVF RLEARAQVLH TWWWRFVGWL LIFFGVTCNT
KILRLLFVRV PLLVALAPDP QFPVTGNLLI AFSLALTIAA VAWILHRPVI GACLLLAGAS
PYVWFTRNLV DYHRLD
