ID   TMM47_DANRE             Reviewed;         181 AA.
AC   Q6PFT6;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Transmembrane protein 47;
DE   AltName: Full=Transmembrane 4 superfamily member 10;
GN   Name=tmem47; Synonyms=tm4sf10; ORFNames=zgc:63990;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates cell junction organization in epithelial cells.
CC       {ECO:0000250|UniProtKB:Q9JJG6, ECO:0000250|UniProtKB:Q9XSV3}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Cell junction, adherens junction
CC       {ECO:0000250|UniProtKB:Q9XSV3}.
CC   -!- SIMILARITY: Belongs to the TMEM47 family. {ECO:0000305}.
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DR   EMBL; BC057424; AAH57424.1; -; mRNA.
DR   RefSeq; NP_999928.1; NM_214763.2.
DR   AlphaFoldDB; Q6PFT6; -.
DR   SMR; Q6PFT6; -.
DR   STRING; 7955.ENSDARP00000104833; -.
DR   PaxDb; Q6PFT6; -.
DR   Ensembl; ENSDART00000123917; ENSDARP00000104833; ENSDARG00000057322.
DR   GeneID; 406640; -.
DR   KEGG; dre:406640; -.
DR   CTD; 83604; -.
DR   ZFIN; ZDB-GENE-040426-2644; tmem47.
DR   eggNOG; KOG4671; Eukaryota.
DR   GeneTree; ENSGT00530000063484; -.
DR   HOGENOM; CLU_120054_1_0_1; -.
DR   InParanoid; Q6PFT6; -.
DR   OMA; EWSCNST; -.
DR   OrthoDB; 1307601at2759; -.
DR   PhylomeDB; Q6PFT6; -.
DR   TreeFam; TF312855; -.
DR   PRO; PR:Q6PFT6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000057322; Expressed in swim bladder and 26 other tissues.
DR   ExpressionAtlas; Q6PFT6; baseline and differential.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   InterPro; IPR015664; P53_induced.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR14399; PTHR14399; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..181
FT                   /note="Transmembrane protein 47"
FT                   /id="PRO_0000072571"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   181 AA;  19947 MW;  1DA80DCE9524B753 CRC64;
     MASSVSGAEE VRVSALTPLK LVGLVCVFLA LCLDVGAVLS PAWVTADDQY HLSLWKSCSK
     PAASATWRCN STLGTDWQIA TLALLLGGAF LILLSFLVAL VSVCIRSRRR FYRPVAIMLF
     AAVVLQACCL VLYPIKFIET ISLRIYHEFN WGYGLAWGAT IFSFGGAILY CLNPKNYEDY
     Y