ID   TMM50_DICDI             Reviewed;         156 AA.
AC   Q54T60;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Transmembrane protein 50 homolog;
GN   Name=tmem50; ORFNames=DDB_G0281983;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0220 family. {ECO:0000305}.
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DR   EMBL; AAFI02000044; EAL66413.1; -; Genomic_DNA.
DR   RefSeq; XP_640391.1; XM_635299.1.
DR   AlphaFoldDB; Q54T60; -.
DR   STRING; 44689.DDB0233326; -.
DR   PaxDb; Q54T60; -.
DR   EnsemblProtists; EAL66413; EAL66413; DDB_G0281983.
DR   GeneID; 8623346; -.
DR   KEGG; ddi:DDB_G0281983; -.
DR   dictyBase; DDB_G0281983; tmem50.
DR   eggNOG; KOG3393; Eukaryota.
DR   HOGENOM; CLU_156199_0_0_1; -.
DR   InParanoid; Q54T60; -.
DR   OMA; VHITFVD; -.
DR   PhylomeDB; Q54T60; -.
DR   PRO; PR:Q54T60; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   InterPro; IPR007919; UPF0220.
DR   PANTHER; PTHR13180; PTHR13180; 1.
DR   Pfam; PF05255; UPF0220; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..156
FT                   /note="Transmembrane protein 50 homolog"
FT                   /id="PRO_0000328501"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   156 AA;  17495 MW;  A4699E67F883A774 CRC64;
     MRKTIMKYLP ALAGIIFTAG WFLWIDGHVY ENTNNKNADF DGPHIQWIYY LPGIFATLGM
     VMANIVDLSA LNSNSLLFDG GATKVRVWLF ISFAISFGCI GAALWIMVAV FLPPHNTNDA
     AQWPGIAITL QTSLIFLSSL LLVFKKVRQD DEYDQF