TMM51_HUMAN
ID TMM51_HUMAN Reviewed; 253 AA.
AC Q9NW97; A8K819;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Transmembrane protein 51;
GN Name=TMEM51; Synonyms=C1orf72;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115; SER-182 AND SER-192, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9NW97; Q13520: AQP6; NbExp=3; IntAct=EBI-726044, EBI-13059134;
CC Q9NW97; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-726044, EBI-747430;
CC Q9NW97; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-726044, EBI-12003442;
CC Q9NW97; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-726044, EBI-9083477;
CC Q9NW97; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-726044, EBI-10271156;
CC Q9NW97; P00387: CYB5R3; NbExp=3; IntAct=EBI-726044, EBI-1046040;
CC Q9NW97; P78329: CYP4F2; NbExp=3; IntAct=EBI-726044, EBI-1752413;
CC Q9NW97; Q15125: EBP; NbExp=3; IntAct=EBI-726044, EBI-3915253;
CC Q9NW97; P54852: EMP3; NbExp=3; IntAct=EBI-726044, EBI-3907816;
CC Q9NW97; O43681: GET3; NbExp=3; IntAct=EBI-726044, EBI-2515857;
CC Q9NW97; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-726044, EBI-10317425;
CC Q9NW97; Q8N912: NRAC; NbExp=3; IntAct=EBI-726044, EBI-12051377;
CC Q9NW97; Q04941: PLP2; NbExp=3; IntAct=EBI-726044, EBI-608347;
CC Q9NW97; P54829: PTPN5; NbExp=3; IntAct=EBI-726044, EBI-1220572;
CC Q9NW97; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-726044, EBI-7545592;
CC Q9NW97; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-726044, EBI-10244780;
CC Q9NW97; P60059: SEC61G; NbExp=3; IntAct=EBI-726044, EBI-4402709;
CC Q9NW97; O95562: SFT2D2; NbExp=3; IntAct=EBI-726044, EBI-4402330;
CC Q9NW97; A0A1P0AYU5: SFXN3; NbExp=3; IntAct=EBI-726044, EBI-14193895;
CC Q9NW97; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-726044, EBI-10226799;
CC Q9NW97; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-726044, EBI-12188413;
CC Q9NW97; P0DN84: STRIT1; NbExp=3; IntAct=EBI-726044, EBI-12200293;
CC Q9NW97; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-726044, EBI-12845616;
CC Q9NW97; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-726044, EBI-2800360;
CC Q9NW97; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-726044, EBI-8638294;
CC Q9NW97; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-726044, EBI-10315004;
CC Q9NW97; Q8TBM7: TMEM254; NbExp=3; IntAct=EBI-726044, EBI-11956809;
CC Q9NW97; Q9Y320: TMX2; NbExp=3; IntAct=EBI-726044, EBI-6447886;
CC Q9NW97; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-726044, EBI-12003468;
CC Q9NW97; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-726044, EBI-988826;
CC Q9NW97; O75379: VAMP4; NbExp=3; IntAct=EBI-726044, EBI-744953;
CC Q9NW97; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-726044, EBI-723716;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK001061; BAA91486.1; -; mRNA.
DR EMBL; AK292184; BAF84873.1; -; mRNA.
DR EMBL; CR457120; CAG33401.1; -; mRNA.
DR EMBL; AL391094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471167; EAW51711.1; -; Genomic_DNA.
DR EMBL; BC000202; AAH00202.1; -; mRNA.
DR EMBL; BC000593; AAH00593.1; -; mRNA.
DR CCDS; CCDS154.1; -.
DR RefSeq; NP_001129688.1; NM_001136216.1.
DR RefSeq; NP_001129689.1; NM_001136217.1.
DR RefSeq; NP_001129690.1; NM_001136218.1.
DR RefSeq; NP_001306594.1; NM_001319665.1.
DR RefSeq; NP_060492.1; NM_018022.2.
DR RefSeq; XP_005245976.1; XM_005245919.1.
DR RefSeq; XP_011539978.1; XM_011541676.1.
DR RefSeq; XP_016857079.1; XM_017001590.1.
DR AlphaFoldDB; Q9NW97; -.
DR BioGRID; 120404; 110.
DR IntAct; Q9NW97; 60.
DR MINT; Q9NW97; -.
DR STRING; 9606.ENSP00000394899; -.
DR iPTMnet; Q9NW97; -.
DR PhosphoSitePlus; Q9NW97; -.
DR BioMuta; TMEM51; -.
DR DMDM; 68053240; -.
DR EPD; Q9NW97; -.
DR jPOST; Q9NW97; -.
DR MassIVE; Q9NW97; -.
DR MaxQB; Q9NW97; -.
DR PaxDb; Q9NW97; -.
DR PeptideAtlas; Q9NW97; -.
DR PRIDE; Q9NW97; -.
DR ProteomicsDB; 82915; -.
DR Antibodypedia; 3057; 40 antibodies from 16 providers.
DR DNASU; 55092; -.
DR Ensembl; ENST00000376008.3; ENSP00000365176.1; ENSG00000171729.14.
DR Ensembl; ENST00000376014.7; ENSP00000365182.3; ENSG00000171729.14.
DR Ensembl; ENST00000400796.7; ENSP00000383600.2; ENSG00000171729.14.
DR Ensembl; ENST00000428417.5; ENSP00000394899.1; ENSG00000171729.14.
DR GeneID; 55092; -.
DR KEGG; hsa:55092; -.
DR MANE-Select; ENST00000376008.3; ENSP00000365176.1; NM_001136218.2; NP_001129690.1.
DR UCSC; uc001avw.5; human.
DR CTD; 55092; -.
DR DisGeNET; 55092; -.
DR GeneCards; TMEM51; -.
DR HGNC; HGNC:25488; TMEM51.
DR HPA; ENSG00000171729; Low tissue specificity.
DR neXtProt; NX_Q9NW97; -.
DR OpenTargets; ENSG00000171729; -.
DR PharmGKB; PA142670767; -.
DR VEuPathDB; HostDB:ENSG00000171729; -.
DR eggNOG; ENOG502QU2P; Eukaryota.
DR GeneTree; ENSGT00390000009278; -.
DR HOGENOM; CLU_1115460_0_0_1; -.
DR InParanoid; Q9NW97; -.
DR OMA; MIVWTMV; -.
DR OrthoDB; 1229287at2759; -.
DR PhylomeDB; Q9NW97; -.
DR TreeFam; TF332361; -.
DR PathwayCommons; Q9NW97; -.
DR SignaLink; Q9NW97; -.
DR BioGRID-ORCS; 55092; 10 hits in 1078 CRISPR screens.
DR ChiTaRS; TMEM51; human.
DR GeneWiki; TMEM51_(gene); -.
DR GenomeRNAi; 55092; -.
DR Pharos; Q9NW97; Tdark.
DR PRO; PR:Q9NW97; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NW97; protein.
DR Bgee; ENSG00000171729; Expressed in body of pancreas and 132 other tissues.
DR ExpressionAtlas; Q9NW97; baseline and differential.
DR Genevisible; Q9NW97; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029265; TMEM51.
DR PANTHER; PTHR16015; PTHR16015; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..253
FT /note="Transmembrane protein 51"
FT /id="PRO_0000072577"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 93..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 115
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 192
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 34
FT /note="V -> A (in dbSNP:rs17405421)"
FT /id="VAR_051446"
FT VARIANT 92
FT /note="R -> Q (in dbSNP:rs3766158)"
FT /id="VAR_051447"
SQ SEQUENCE 253 AA; 27759 MW; C0CC36D41C57157C CRC64;
MMAQSKANGS HYALTAIGLG MLVLGVIMAM WNLVPGFSAA EKPTAQGSNK TEVGGGILKS
KTFSVAYVLV GAGVMLLLLS ICLSIRDKRK QRQGEDLAHV QHPTGAGPHA QEEDSQEEEE
EDEEAASRYY VPSYEEVMNT NYSEARGEEQ NPRLSISLPS YESLTGLDET TPTSTRADVE
ASPGNPPDRQ NSKLAKRLKP LKVRRIKSEK LHLKDFRINL PDKNVPPPSI EPLTPPPQYD
EVQEKAPDTR PPD
