ID   TMM53_DANRE             Reviewed;         281 AA.
AC   Q6DHN0;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Transmembrane protein 53;
GN   Name=tmem53; ORFNames=zgc:92204;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM53 family. {ECO:0000305}.
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DR   EMBL; BC075937; AAH75937.1; -; mRNA.
DR   RefSeq; NP_001002637.1; NM_001002637.1.
DR   AlphaFoldDB; Q6DHN0; -.
DR   SMR; Q6DHN0; -.
DR   STRING; 7955.ENSDARP00000056648; -.
DR   ESTHER; danre-tmm53; Duf_829.
DR   PaxDb; Q6DHN0; -.
DR   Ensembl; ENSDART00000056649; ENSDARP00000056648; ENSDARG00000038789.
DR   GeneID; 436910; -.
DR   KEGG; dre:436910; -.
DR   CTD; 79639; -.
DR   ZFIN; ZDB-GENE-040718-384; tmem53.
DR   eggNOG; KOG2521; Eukaryota.
DR   GeneTree; ENSGT00390000000715; -.
DR   HOGENOM; CLU_036503_1_0_1; -.
DR   InParanoid; Q6DHN0; -.
DR   OMA; SPHVKHY; -.
DR   OrthoDB; 916101at2759; -.
DR   PhylomeDB; Q6DHN0; -.
DR   TreeFam; TF313176; -.
DR   PRO; PR:Q6DHN0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000038789; Expressed in mature ovarian follicle and 26 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR008547; DUF829_TMEM53.
DR   PANTHER; PTHR12265; PTHR12265; 1.
DR   Pfam; PF05705; DUF829; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..281
FT                   /note="Transmembrane protein 53"
FT                   /id="PRO_0000284120"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   281 AA;  32512 MW;  87EF1267285219B6 CRC64;
     MGDDDLDYNI VFSEALISEK HWRGSKEPVV ILLGWAGSRD KHLAKYSSIY NEQGCTTLRY
     TAPLKTVFIS ESLGYKELRS TAHKLLELLY DYEVENNPIF FHVFSNGGFM LYRYMVELLH
     SHKQFSTLCV VGTVVDSAPG SQNVVGALRA LKTTLGPKVN VLLQYFLLAL FAVAVFLLRI
     VLYPLTKYFH RNHYDAMMEH PAPWPQMYLY SRADRVIRYR DVEKMVKGLQ EKGLMVESFD
     FITPAHVSLF RDCPEDYSNR CRTFLSHCMT TSEEILMKKH H