TMM53_MOUSE
ID TMM53_MOUSE Reviewed; 276 AA.
AC Q9D0Z3; A2AE66; Q8VDW5; Q9DAF0;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transmembrane protein 53;
GN Name=Tmem53;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9D0Z3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D0Z3-2; Sequence=VSP_024449;
CC Name=3;
CC IsoId=Q9D0Z3-3; Sequence=VSP_024447, VSP_024448;
CC -!- SIMILARITY: Belongs to the TMEM53 family. {ECO:0000305}.
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DR EMBL; AK004164; BAB23200.1; -; mRNA.
DR EMBL; AK005885; BAB24300.1; -; mRNA.
DR EMBL; AL671866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL844169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019937; AAH19937.1; -; mRNA.
DR EMBL; BC020121; AAH20121.1; -; mRNA.
DR CCDS; CCDS18533.1; -. [Q9D0Z3-1]
DR CCDS; CCDS71453.1; -. [Q9D0Z3-2]
DR CCDS; CCDS71454.1; -. [Q9D0Z3-3]
DR RefSeq; NP_001272741.1; NM_001285812.1. [Q9D0Z3-2]
DR RefSeq; NP_001272743.1; NM_001285814.1. [Q9D0Z3-3]
DR RefSeq; NP_001272744.1; NM_001285815.1.
DR RefSeq; NP_001272745.1; NM_001285816.1.
DR RefSeq; NP_081113.1; NM_026837.3. [Q9D0Z3-1]
DR RefSeq; NP_083865.1; NM_029589.1. [Q9D0Z3-3]
DR AlphaFoldDB; Q9D0Z3; -.
DR BioGRID; 213046; 2.
DR STRING; 10090.ENSMUSP00000061523; -.
DR ESTHER; mouse-tmm53; Duf_829.
DR iPTMnet; Q9D0Z3; -.
DR PhosphoSitePlus; Q9D0Z3; -.
DR MaxQB; Q9D0Z3; -.
DR PaxDb; Q9D0Z3; -.
DR PRIDE; Q9D0Z3; -.
DR ProteomicsDB; 259259; -. [Q9D0Z3-1]
DR ProteomicsDB; 259260; -. [Q9D0Z3-2]
DR ProteomicsDB; 259261; -. [Q9D0Z3-3]
DR Antibodypedia; 18471; 53 antibodies from 13 providers.
DR DNASU; 68777; -.
DR Ensembl; ENSMUST00000062824; ENSMUSP00000061523; ENSMUSG00000048772. [Q9D0Z3-1]
DR Ensembl; ENSMUST00000106433; ENSMUSP00000102041; ENSMUSG00000048772. [Q9D0Z3-3]
DR Ensembl; ENSMUST00000106434; ENSMUSP00000102042; ENSMUSG00000048772. [Q9D0Z3-2]
DR GeneID; 68777; -.
DR KEGG; mmu:68777; -.
DR UCSC; uc008uii.2; mouse. [Q9D0Z3-1]
DR UCSC; uc008uij.2; mouse. [Q9D0Z3-2]
DR UCSC; uc008uik.2; mouse. [Q9D0Z3-3]
DR CTD; 79639; -.
DR MGI; MGI:1916027; Tmem53.
DR VEuPathDB; HostDB:ENSMUSG00000048772; -.
DR eggNOG; KOG2521; Eukaryota.
DR GeneTree; ENSGT00390000000715; -.
DR HOGENOM; CLU_036503_1_0_1; -.
DR InParanoid; Q9D0Z3; -.
DR OMA; SPHVKHY; -.
DR OrthoDB; 916101at2759; -.
DR PhylomeDB; Q9D0Z3; -.
DR TreeFam; TF313176; -.
DR BioGRID-ORCS; 68777; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tmem53; mouse.
DR PRO; PR:Q9D0Z3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D0Z3; protein.
DR Bgee; ENSMUSG00000048772; Expressed in seminiferous tubule of testis and 112 other tissues.
DR ExpressionAtlas; Q9D0Z3; baseline and differential.
DR Genevisible; Q9D0Z3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR008547; DUF829_TMEM53.
DR PANTHER; PTHR12265; PTHR12265; 1.
DR Pfam; PF05705; DUF829; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..276
FT /note="Transmembrane protein 53"
FT /id="PRO_0000284119"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..15
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024447"
FT VAR_SEQ 16..20
FT /note="PCWSQ -> MNPDG (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024448"
FT VAR_SEQ 21
FT /note="K -> SMEGDWEE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024449"
SQ SEQUENCE 276 AA; 31589 MW; 58FF99CF4A580CE9 CRC64;
MASAELDYSI EIPDQPCWSQ KNRQGGKEAG KQQPVVILLG WGGCRDKNLA KYSAIYHKRG
CIVIRYTAPW HMVFFSESLG IPSLRVIAQK LLELLFDYEI EREPLLFHVF SNAGVMLYRY
VLELLQTHQR FRHLHVVGTI FDSGPGDSNL IGALRALATI LERRPAVLRL LLLAAFALVV
ILFHFLLAPF TALFHTHFYD RLQDSGSCWP ELYLYSRADK VVSARDVERM VEARLAHQVM
VRGVDFVSSA HVSHLRDYPT YYTSLCVDFM HNCVQC
