TMM54_MOUSE
ID TMM54_MOUSE Reviewed; 219 AA.
AC Q9D7S1; A2A7R3; Q8VCL0;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transmembrane protein 54;
GN Name=Tmem54;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM54 family. {ECO:0000305}.
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DR EMBL; AK008935; BAB25977.1; -; mRNA.
DR EMBL; AL606977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC019563; AAH19563.1; -; mRNA.
DR CCDS; CCDS18681.1; -.
DR RefSeq; NP_001277635.1; NM_001290706.1.
DR RefSeq; NP_079728.2; NM_025452.4.
DR AlphaFoldDB; Q9D7S1; -.
DR STRING; 10090.ENSMUSP00000101679; -.
DR PhosphoSitePlus; Q9D7S1; -.
DR PaxDb; Q9D7S1; -.
DR PRIDE; Q9D7S1; -.
DR ProteomicsDB; 259130; -.
DR Antibodypedia; 31378; 17 antibodies from 11 providers.
DR DNASU; 66260; -.
DR Ensembl; ENSMUST00000106064; ENSMUSP00000101679; ENSMUSG00000028786.
DR GeneID; 66260; -.
DR KEGG; mmu:66260; -.
DR UCSC; uc008uvz.2; mouse.
DR CTD; 113452; -.
DR MGI; MGI:1913510; Tmem54.
DR VEuPathDB; HostDB:ENSMUSG00000028786; -.
DR eggNOG; ENOG502S0UN; Eukaryota.
DR GeneTree; ENSGT00390000004700; -.
DR InParanoid; Q9D7S1; -.
DR OMA; FAVRCSQ; -.
DR OrthoDB; 1133009at2759; -.
DR PhylomeDB; Q9D7S1; -.
DR TreeFam; TF332771; -.
DR BioGRID-ORCS; 66260; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem54; mouse.
DR PRO; PR:Q9D7S1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D7S1; protein.
DR Bgee; ENSMUSG00000028786; Expressed in duodenum and 101 other tissues.
DR ExpressionAtlas; Q9D7S1; baseline and differential.
DR Genevisible; Q9D7S1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR020977; Beta-casein-like.
DR PANTHER; PTHR31258; PTHR31258; 1.
DR Pfam; PF12304; BCLP; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..219
FT /note="Transmembrane protein 54"
FT /id="PRO_0000226990"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 195
FT /note="C -> Y (in Ref. 3; AAH19563)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 23427 MW; 5FC61DFE24085D9A CRC64;
MCLRIGSLNV DEFRKVLMKT GLVLVVLGHV SFIAAAVLHG TMLRFVATTS DAVVLQYCAV
DILSVTSAIV VIVAGISTIV LSRYLPSTPL RWTVFSLSVA CALLSLTCAL GLLASIAVTF
ATKGRALLAA CTFENPELPT LAPDCPFDPT RIYSSSLCLW AISLIFCLAE SMSAVRCAQL
MHGLLELRPW WGKSCHHTIQ ASPEPLDAHD LLSCASSCS
