TMM60_HUMAN
ID TMM60_HUMAN Reviewed; 133 AA.
AC Q9H2L4; A4D1C3; Q86UM0;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transmembrane protein 60;
GN Name=TMEM60; Synonyms=C7orf35; ORFNames=DC32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Dendritic cell;
RA Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.;
RT "Novel genes expressed in human dendritic cell.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9H2L4; Q86WK6: AMIGO1; NbExp=3; IntAct=EBI-2852148, EBI-19125216;
CC Q9H2L4; Q68DC2: ANKS6; NbExp=3; IntAct=EBI-2852148, EBI-7054139;
CC Q9H2L4; Q9BQE5: APOL2; NbExp=3; IntAct=EBI-2852148, EBI-4290634;
CC Q9H2L4; P41181: AQP2; NbExp=3; IntAct=EBI-2852148, EBI-12701138;
CC Q9H2L4; Q13520: AQP6; NbExp=3; IntAct=EBI-2852148, EBI-13059134;
CC Q9H2L4; P07307-3: ASGR2; NbExp=3; IntAct=EBI-2852148, EBI-12808270;
CC Q9H2L4; Q8NFU1: BEST2; NbExp=3; IntAct=EBI-2852148, EBI-19947314;
CC Q9H2L4; Q13323: BIK; NbExp=3; IntAct=EBI-2852148, EBI-700794;
CC Q9H2L4; Q8WZ55: BSND; NbExp=3; IntAct=EBI-2852148, EBI-7996695;
CC Q9H2L4; Q9UGN4: CD300A; NbExp=3; IntAct=EBI-2852148, EBI-10320732;
CC Q9H2L4; P19397: CD53; NbExp=3; IntAct=EBI-2852148, EBI-6657396;
CC Q9H2L4; P04233-2: CD74; NbExp=3; IntAct=EBI-2852148, EBI-12222807;
CC Q9H2L4; O95471: CLDN7; NbExp=3; IntAct=EBI-2852148, EBI-740744;
CC Q9H2L4; P34972: CNR2; NbExp=3; IntAct=EBI-2852148, EBI-2835940;
CC Q9H2L4; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-2852148, EBI-18013275;
CC Q9H2L4; P00387: CYB5R3; NbExp=3; IntAct=EBI-2852148, EBI-1046040;
CC Q9H2L4; Q15125: EBP; NbExp=3; IntAct=EBI-2852148, EBI-3915253;
CC Q9H2L4; Q92838: EDA; NbExp=3; IntAct=EBI-2852148, EBI-529425;
CC Q9H2L4; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-2852148, EBI-781551;
CC Q9H2L4; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-2852148, EBI-17973325;
CC Q9H2L4; P34910-2: EVI2B; NbExp=3; IntAct=EBI-2852148, EBI-17640610;
CC Q9H2L4; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-2852148, EBI-18304435;
CC Q9H2L4; O15552: FFAR2; NbExp=3; IntAct=EBI-2852148, EBI-2833872;
CC Q9H2L4; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-2852148, EBI-12142257;
CC Q9H2L4; P48165: GJA8; NbExp=3; IntAct=EBI-2852148, EBI-17458373;
CC Q9H2L4; O95377: GJB5; NbExp=3; IntAct=EBI-2852148, EBI-3909454;
CC Q9H2L4; O95452: GJB6; NbExp=3; IntAct=EBI-2852148, EBI-13345609;
CC Q9H2L4; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-2852148, EBI-3917143;
CC Q9H2L4; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-2852148, EBI-13345167;
CC Q9H2L4; O15529: GPR42; NbExp=3; IntAct=EBI-2852148, EBI-18076404;
CC Q9H2L4; Q9BZJ8: GPR61; NbExp=3; IntAct=EBI-2852148, EBI-12808020;
CC Q9H2L4; Q8TED1: GPX8; NbExp=3; IntAct=EBI-2852148, EBI-11721746;
CC Q9H2L4; Q9BSE4: HERPUD2; NbExp=3; IntAct=EBI-2852148, EBI-2868124;
CC Q9H2L4; P31937: HIBADH; NbExp=3; IntAct=EBI-2852148, EBI-11427100;
CC Q9H2L4; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-2852148, EBI-1052304;
CC Q9H2L4; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-2852148, EBI-18053395;
CC Q9H2L4; P38484: IFNGR2; NbExp=3; IntAct=EBI-2852148, EBI-3905457;
CC Q9H2L4; Q13651: IL10RA; NbExp=3; IntAct=EBI-2852148, EBI-1031656;
CC Q9H2L4; P16871: IL7R; NbExp=3; IntAct=EBI-2852148, EBI-80490;
CC Q9H2L4; O95279: KCNK5; NbExp=3; IntAct=EBI-2852148, EBI-3934936;
CC Q9H2L4; Q8IYS2: KIAA2013; NbExp=3; IntAct=EBI-2852148, EBI-2866116;
CC Q9H2L4; O95214: LEPROTL1; NbExp=3; IntAct=EBI-2852148, EBI-750776;
CC Q9H2L4; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-2852148, EBI-17490413;
CC Q9H2L4; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-2852148, EBI-2820517;
CC Q9H2L4; Q96PB8: LRRC3B; NbExp=3; IntAct=EBI-2852148, EBI-17775622;
CC Q9H2L4; Q96AG4: LRRC59; NbExp=3; IntAct=EBI-2852148, EBI-358888;
CC Q9H2L4; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-2852148, EBI-11956541;
CC Q9H2L4; O14880: MGST3; NbExp=3; IntAct=EBI-2852148, EBI-724754;
CC Q9H2L4; Q15546: MMD; NbExp=3; IntAct=EBI-2852148, EBI-17873222;
CC Q9H2L4; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-2852148, EBI-6163737;
CC Q9H2L4; O75459: PAGE1; NbExp=3; IntAct=EBI-2852148, EBI-2559100;
CC Q9H2L4; O15173: PGRMC2; NbExp=3; IntAct=EBI-2852148, EBI-1050125;
CC Q9H2L4; Q6UXB8: PI16; NbExp=3; IntAct=EBI-2852148, EBI-12810028;
CC Q9H2L4; Q9BRK0: REEP2; NbExp=3; IntAct=EBI-2852148, EBI-11337973;
CC Q9H2L4; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-2852148, EBI-7545592;
CC Q9H2L4; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-2852148, EBI-10192441;
CC Q9H2L4; Q9UBD6: RHCG; NbExp=3; IntAct=EBI-2852148, EBI-15853497;
CC Q9H2L4; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-2852148, EBI-18397230;
CC Q9H2L4; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-2852148, EBI-3920694;
CC Q9H2L4; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-2852148, EBI-17247926;
CC Q9H2L4; Q14973: SLC10A1; NbExp=3; IntAct=EBI-2852148, EBI-3923031;
CC Q9H2L4; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-2852148, EBI-18159983;
CC Q9H2L4; Q9UKG4: SLC13A4; NbExp=3; IntAct=EBI-2852148, EBI-12808018;
CC Q9H2L4; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-2852148, EBI-17595455;
CC Q9H2L4; Q9BRI3: SLC30A2; NbExp=5; IntAct=EBI-2852148, EBI-8644112;
CC Q9H2L4; O14863: SLC30A4; NbExp=3; IntAct=EBI-2852148, EBI-13918058;
CC Q9H2L4; Q7Z769: SLC35E3; NbExp=3; IntAct=EBI-2852148, EBI-13389236;
CC Q9H2L4; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-2852148, EBI-9978441;
CC Q9H2L4; Q9NY26: SLC39A1; NbExp=3; IntAct=EBI-2852148, EBI-726491;
CC Q9H2L4; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-2852148, EBI-12898013;
CC Q9H2L4; P02730: SLC4A1; NbExp=3; IntAct=EBI-2852148, EBI-7576138;
CC Q9H2L4; Q9H2J7: SLC6A15; NbExp=3; IntAct=EBI-2852148, EBI-11343466;
CC Q9H2L4; Q9UHI5: SLC7A8; NbExp=3; IntAct=EBI-2852148, EBI-13292283;
CC Q9H2L4; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-2852148, EBI-10819434;
CC Q9H2L4; Q6ZMD2-2: SPNS3; NbExp=3; IntAct=EBI-2852148, EBI-17848320;
CC Q9H2L4; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-2852148, EBI-17280858;
CC Q9H2L4; P27105: STOM; NbExp=3; IntAct=EBI-2852148, EBI-1211440;
CC Q9H2L4; Q16623: STX1A; NbExp=3; IntAct=EBI-2852148, EBI-712466;
CC Q9H2L4; P21579: SYT1; NbExp=3; IntAct=EBI-2852148, EBI-524909;
CC Q9H2L4; Q8WY91: THAP4; NbExp=3; IntAct=EBI-2852148, EBI-726691;
CC Q9H2L4; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-2852148, EBI-12947623;
CC Q9H2L4; Q8N6Q1: TMCO5A; NbExp=3; IntAct=EBI-2852148, EBI-12821895;
CC Q9H2L4; Q9BVK6: TMED9; NbExp=3; IntAct=EBI-2852148, EBI-1056827;
CC Q9H2L4; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-2852148, EBI-7238458;
CC Q9H2L4; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-2852148, EBI-8638294;
CC Q9H2L4; Q969S6: TMEM203; NbExp=3; IntAct=EBI-2852148, EBI-12274070;
CC Q9H2L4; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-2852148, EBI-10982110;
CC Q9H2L4; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-2852148, EBI-3923061;
CC Q9H2L4; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-2852148, EBI-18178701;
CC Q9H2L4; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-2852148, EBI-2548832;
CC Q9H2L4; Q9P0T7: TMEM9; NbExp=3; IntAct=EBI-2852148, EBI-723976;
CC Q9H2L4; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-2852148, EBI-11724433;
CC Q9H2L4; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-2852148, EBI-12345267;
CC Q9H2L4; Q9H313-4: TTYH1; NbExp=3; IntAct=EBI-2852148, EBI-17671298;
CC Q9H2L4; Q3ZAQ7: VMA21; NbExp=3; IntAct=EBI-2852148, EBI-1055364;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH65930.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF260336; AAG44667.1; -; mRNA.
DR EMBL; AC004955; AAP21882.1; -; Genomic_DNA.
DR EMBL; AC004955; AAP21883.1; -; Genomic_DNA.
DR EMBL; CH236949; EAL24196.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW77032.1; -; Genomic_DNA.
DR EMBL; BC065930; AAH65930.1; ALT_INIT; mRNA.
DR CCDS; CCDS5593.1; -.
DR RefSeq; NP_116325.1; NM_032936.3.
DR AlphaFoldDB; Q9H2L4; -.
DR BioGRID; 124434; 89.
DR IntAct; Q9H2L4; 96.
DR STRING; 9606.ENSP00000257663; -.
DR TCDB; 8.A.76.1.2; the tmem203 or pf14967 (tmem203) family.
DR BioMuta; TMEM60; -.
DR DMDM; 47605551; -.
DR PaxDb; Q9H2L4; -.
DR PRIDE; Q9H2L4; -.
DR ProteomicsDB; 80561; -.
DR Antibodypedia; 71000; 4 antibodies from 4 providers.
DR DNASU; 85025; -.
DR Ensembl; ENST00000257663.4; ENSP00000257663.3; ENSG00000135211.6.
DR GeneID; 85025; -.
DR KEGG; hsa:85025; -.
DR MANE-Select; ENST00000257663.4; ENSP00000257663.3; NM_032936.4; NP_116325.1.
DR UCSC; uc003ugn.4; human.
DR CTD; 85025; -.
DR DisGeNET; 85025; -.
DR GeneCards; TMEM60; -.
DR HGNC; HGNC:21754; TMEM60.
DR HPA; ENSG00000135211; Low tissue specificity.
DR neXtProt; NX_Q9H2L4; -.
DR OpenTargets; ENSG00000135211; -.
DR PharmGKB; PA134910139; -.
DR VEuPathDB; HostDB:ENSG00000135211; -.
DR eggNOG; KOG3879; Eukaryota.
DR GeneTree; ENSGT00390000007283; -.
DR HOGENOM; CLU_152149_0_0_1; -.
DR InParanoid; Q9H2L4; -.
DR OMA; FIPLWLY; -.
DR OrthoDB; 1512798at2759; -.
DR PhylomeDB; Q9H2L4; -.
DR TreeFam; TF325897; -.
DR PathwayCommons; Q9H2L4; -.
DR SignaLink; Q9H2L4; -.
DR BioGRID-ORCS; 85025; 14 hits in 1082 CRISPR screens.
DR ChiTaRS; TMEM60; human.
DR GenomeRNAi; 85025; -.
DR Pharos; Q9H2L4; Tdark.
DR PRO; PR:Q9H2L4; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9H2L4; protein.
DR Bgee; ENSG00000135211; Expressed in secondary oocyte and 183 other tissues.
DR Genevisible; Q9H2L4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019396; TM_Fragile-X-F-assoc.
DR PANTHER; PTHR13568; PTHR13568; 1.
DR Pfam; PF10269; Tmemb_185A; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..133
FT /note="Transmembrane protein 60"
FT /id="PRO_0000072581"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 42
FT /note="V -> G (in dbSNP:rs34580932)"
FT /id="VAR_051449"
SQ SEQUENCE 133 AA; 15500 MW; 9E4064FF94F70A7D CRC64;
MRMSLAQRVL LTWLFTLLFL IMLVLKLDEK APWNWFLIFI PVWIFDTILL VLLIVKMAGR
CKSGFDPRHG SHNIKKKAWY LIAMLLKLAF CLALCAKLEQ FTTMNLSYVF IPLWALLAGA
LTELGYNVFF VRD
