TMM61_HUMAN
ID TMM61_HUMAN Reviewed; 210 AA.
AC Q8N0U2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Transmembrane protein 61;
GN Name=TMEM61;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N0U2; P07550: ADRB2; NbExp=3; IntAct=EBI-25830583, EBI-491169;
CC Q8N0U2; G5E9A7: DMWD; NbExp=3; IntAct=EBI-25830583, EBI-10976677;
CC Q8N0U2; P22607: FGFR3; NbExp=3; IntAct=EBI-25830583, EBI-348399;
CC Q8N0U2; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-25830583, EBI-10226858;
CC Q8N0U2; Q14957: GRIN2C; NbExp=3; IntAct=EBI-25830583, EBI-8285963;
CC Q8N0U2; P28799: GRN; NbExp=3; IntAct=EBI-25830583, EBI-747754;
CC Q8N0U2; P06396: GSN; NbExp=3; IntAct=EBI-25830583, EBI-351506;
CC Q8N0U2; P54652: HSPA2; NbExp=3; IntAct=EBI-25830583, EBI-356991;
CC Q8N0U2; O60333-2: KIF1B; NbExp=3; IntAct=EBI-25830583, EBI-10975473;
CC Q8N0U2; D3DTS7: PMP22; NbExp=3; IntAct=EBI-25830583, EBI-25882629;
CC Q8N0U2; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-25830583, EBI-396669;
CC Q8N0U2; P49591: SARS1; NbExp=3; IntAct=EBI-25830583, EBI-1053431;
CC Q8N0U2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-25830583, EBI-5235340;
CC Q8N0U2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-25830583, EBI-12806590;
CC Q8N0U2; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-25830583, EBI-741480;
CC Q8N0U2; O76024: WFS1; NbExp=3; IntAct=EBI-25830583, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL590440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029775; AAH29775.1; -; mRNA.
DR CCDS; CCDS601.1; -.
DR RefSeq; NP_872338.1; NM_182532.2.
DR RefSeq; XP_011539213.1; XM_011540911.2.
DR AlphaFoldDB; Q8N0U2; -.
DR IntAct; Q8N0U2; 18.
DR STRING; 9606.ENSP00000360315; -.
DR BioMuta; TMEM61; -.
DR DMDM; 74750872; -.
DR MassIVE; Q8N0U2; -.
DR PaxDb; Q8N0U2; -.
DR PeptideAtlas; Q8N0U2; -.
DR PRIDE; Q8N0U2; -.
DR Antibodypedia; 33228; 41 antibodies from 13 providers.
DR DNASU; 199964; -.
DR Ensembl; ENST00000371268.4; ENSP00000360315.3; ENSG00000143001.5.
DR GeneID; 199964; -.
DR KEGG; hsa:199964; -.
DR MANE-Select; ENST00000371268.4; ENSP00000360315.3; NM_182532.3; NP_872338.1.
DR UCSC; uc001cyd.3; human.
DR CTD; 199964; -.
DR GeneCards; TMEM61; -.
DR HGNC; HGNC:27296; TMEM61.
DR HPA; ENSG00000143001; Group enriched (kidney, parathyroid gland, pituitary gland, salivary gland).
DR neXtProt; NX_Q8N0U2; -.
DR OpenTargets; ENSG00000143001; -.
DR PharmGKB; PA142670774; -.
DR VEuPathDB; HostDB:ENSG00000143001; -.
DR eggNOG; ENOG502SNNX; Eukaryota.
DR GeneTree; ENSGT00390000007464; -.
DR HOGENOM; CLU_095363_0_0_1; -.
DR InParanoid; Q8N0U2; -.
DR OMA; LGTQPPW; -.
DR OrthoDB; 1527408at2759; -.
DR PhylomeDB; Q8N0U2; -.
DR TreeFam; TF336350; -.
DR PathwayCommons; Q8N0U2; -.
DR SignaLink; Q8N0U2; -.
DR BioGRID-ORCS; 199964; 13 hits in 1062 CRISPR screens.
DR GenomeRNAi; 199964; -.
DR Pharos; Q8N0U2; Tdark.
DR PRO; PR:Q8N0U2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N0U2; protein.
DR Bgee; ENSG00000143001; Expressed in parotid gland and 106 other tissues.
DR Genevisible; Q8N0U2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028164; TMEM61.
DR PANTHER; PTHR37151; PTHR37151; 1.
DR Pfam; PF15105; TMEM61; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..210
FT /note="Transmembrane protein 61"
FT /id="PRO_0000254130"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 140..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 40
FT /note="E -> K (in dbSNP:rs3737832)"
FT /id="VAR_028820"
SQ SEQUENCE 210 AA; 22170 MW; 44E412BA0E8E84EF CRC64;
MALPQMCDGS HLASTLRYCM TVSGTVVLVA GTLCFAWWSE GDATAQPGQL APPTEYPVPE
GPSPLLRSVS FVCCGAGGLL LLIGLLWSVK ASIPGPPRWD PYHLSRDLYY LTVESSEKES
CRTPKVVDIP TYEEAVSFPV AEGPPTPPAY PTEEALEPSG SRDALLSTQP AWPPPSYESI
SLALDAVSAE TTPSATRSCS GLVQTARGGS
