TMM62_HUMAN
ID TMM62_HUMAN Reviewed; 643 AA.
AC Q0P6H9; Q6I9Y5; Q9H5J6;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Transmembrane protein 62;
GN Name=TMEM62;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-643.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 209-643.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-180.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15630.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC009981; AAH09981.2; -; mRNA.
DR EMBL; AK027028; BAB15630.1; ALT_INIT; mRNA.
DR EMBL; CR457370; CAG33651.1; -; mRNA.
DR CCDS; CCDS32210.1; -.
DR RefSeq; NP_079232.3; NM_024956.3.
DR RefSeq; XP_011520375.1; XM_011522073.1.
DR AlphaFoldDB; Q0P6H9; -.
DR BioGRID; 123075; 18.
DR IntAct; Q0P6H9; 9.
DR MINT; Q0P6H9; -.
DR STRING; 9606.ENSP00000260403; -.
DR GlyGen; Q0P6H9; 4 sites.
DR iPTMnet; Q0P6H9; -.
DR PhosphoSitePlus; Q0P6H9; -.
DR BioMuta; TMEM62; -.
DR DMDM; 126256322; -.
DR EPD; Q0P6H9; -.
DR jPOST; Q0P6H9; -.
DR MassIVE; Q0P6H9; -.
DR MaxQB; Q0P6H9; -.
DR PaxDb; Q0P6H9; -.
DR PeptideAtlas; Q0P6H9; -.
DR PRIDE; Q0P6H9; -.
DR ProteomicsDB; 58779; -.
DR Antibodypedia; 54904; 22 antibodies from 9 providers.
DR DNASU; 80021; -.
DR Ensembl; ENST00000260403.7; ENSP00000260403.2; ENSG00000137842.7.
DR GeneID; 80021; -.
DR KEGG; hsa:80021; -.
DR MANE-Select; ENST00000260403.7; ENSP00000260403.2; NM_024956.4; NP_079232.3.
DR UCSC; uc001zqr.4; human.
DR CTD; 80021; -.
DR GeneCards; TMEM62; -.
DR HGNC; HGNC:26269; TMEM62.
DR HPA; ENSG00000137842; Low tissue specificity.
DR neXtProt; NX_Q0P6H9; -.
DR OpenTargets; ENSG00000137842; -.
DR PharmGKB; PA142670775; -.
DR VEuPathDB; HostDB:ENSG00000137842; -.
DR eggNOG; ENOG502QTBN; Eukaryota.
DR GeneTree; ENSGT00390000016216; -.
DR InParanoid; Q0P6H9; -.
DR OMA; VEWQTYH; -.
DR OrthoDB; 986462at2759; -.
DR PhylomeDB; Q0P6H9; -.
DR TreeFam; TF323442; -.
DR PathwayCommons; Q0P6H9; -.
DR SignaLink; Q0P6H9; -.
DR BioGRID-ORCS; 80021; 9 hits in 1081 CRISPR screens.
DR ChiTaRS; TMEM62; human.
DR GenomeRNAi; 80021; -.
DR Pharos; Q0P6H9; Tdark.
DR PRO; PR:Q0P6H9; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q0P6H9; protein.
DR Bgee; ENSG00000137842; Expressed in sural nerve and 91 other tissues.
DR ExpressionAtlas; Q0P6H9; baseline and differential.
DR Genevisible; Q0P6H9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd07401; MPP_TMEM62_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041871; MPP_TMEM62.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..643
FT /note="Transmembrane protein 62"
FT /id="PRO_0000254136"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 599..619
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT CARBOHYD 467
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 626
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 427
FT /note="T -> A (in Ref. 2; BAB15630)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 643 AA; 73133 MW; E33D1C235DC33BC7 CRC64;
MAAVLALRVV AGLAAAALVA MLLEHYGLAG QPSPLPRPAP PRRPHPAPGP GDSNIFWGLQ
ISDIHLSRFR DPGRAVDLEK FCSETIDIIQ PALVLATGDL TDAKTKEQLG SRQHEVEWQT
YQGILKKTRV MEKTKWLDIK GNHDAFNIPS LDSIKNYYRK YSAVRRDGSF HYVHSTPFGN
YSFICVDATV NPGPKRPYNF FGILDKKKME ELLLLAKESS RSNHTIWFGH FTTSTILSPS
PGIRSIMSSA IAYLCGHLHT LGGLMPVLHT RHFQGTLELE VGDWKDNRRY RIFAFDHDLF
SFADLIFGKW PVVLITNPKS LLYSCGEHEP LERLLHSTHI RVLAFSLSSI TSVTVKIDGV
HLGQAVHVSG PIFVLKWNPR NYSSGTHNIE VIVQDSAGRS KSVHHIFSVQ ENNHLSFDPL
ASFILRTDHY IMARVLFVLI VLSQLTILII FRYRGYPELK EPSGFINLTS FSLHVLSKIN
IFYYSVLLLT LYTVLGPWFF GEIIDGKFGC CFSFGIFVNG HFLQGSITFI IGILQLAFFN
IPLMAYMCWS LLQRCFGHNF RSHLHQRKYL KIMPVHLLML LLYIWQVYSC YFLYATYGTL
AFLFSPLRTW LTLLTPVLIR YVWTLNSTKF GIFMVQLKSH LSS
