TMM62_MOUSE
ID TMM62_MOUSE Reviewed; 643 AA.
AC Q8BXJ9; A2AQ55;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Transmembrane protein 62;
GN Name=Tmem62;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK046793; BAC32871.1; -; mRNA.
DR EMBL; AL844548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC070410; AAH70410.1; -; mRNA.
DR CCDS; CCDS16629.1; -.
DR RefSeq; NP_780494.1; NM_175285.3.
DR AlphaFoldDB; Q8BXJ9; -.
DR STRING; 10090.ENSMUSP00000064310; -.
DR GlyConnect; 2796; 2 N-Linked glycans (1 site).
DR GlyGen; Q8BXJ9; 2 sites, 2 N-linked glycans (1 site).
DR PhosphoSitePlus; Q8BXJ9; -.
DR MaxQB; Q8BXJ9; -.
DR PaxDb; Q8BXJ9; -.
DR PeptideAtlas; Q8BXJ9; -.
DR PRIDE; Q8BXJ9; -.
DR ProteomicsDB; 259037; -.
DR Antibodypedia; 54904; 22 antibodies from 9 providers.
DR DNASU; 96957; -.
DR Ensembl; ENSMUST00000067582; ENSMUSP00000064310; ENSMUSG00000054484.
DR GeneID; 96957; -.
DR KEGG; mmu:96957; -.
DR UCSC; uc008lxe.1; mouse.
DR CTD; 80021; -.
DR MGI; MGI:2139461; Tmem62.
DR VEuPathDB; HostDB:ENSMUSG00000054484; -.
DR eggNOG; ENOG502QTBN; Eukaryota.
DR GeneTree; ENSGT00390000016216; -.
DR InParanoid; Q8BXJ9; -.
DR OMA; VEWQTYH; -.
DR OrthoDB; 986462at2759; -.
DR PhylomeDB; Q8BXJ9; -.
DR TreeFam; TF323442; -.
DR BioGRID-ORCS; 96957; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tmem62; mouse.
DR PRO; PR:Q8BXJ9; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BXJ9; protein.
DR Bgee; ENSMUSG00000054484; Expressed in cerebellar vermis and 217 other tissues.
DR ExpressionAtlas; Q8BXJ9; baseline and differential.
DR Genevisible; Q8BXJ9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd07401; MPP_TMEM62_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041871; MPP_TMEM62.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..643
FT /note="Transmembrane protein 62"
FT /id="PRO_0000254137"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 484..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 532..552
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 643 AA; 72862 MW; D3E6E8DAFDFB8D46 CRC64;
MARMLAVRVV AGLAAAAVAA LLLEHYGLAG PTTPLPKPRG SQRPHPAPGS EANNIFWGLQ
ISDIHLSRFQ DPGRALALEK FCSETIDIIQ PALVLATGDL TDAKTKEHLG SRQHEVEWQT
YQRILKKTRV MEKTKWLDIK GNHDAYNIPS LESIANYYRK YSAVRKDGAF HHIHSTPFGN
YSFISVDATQ RPGPKRPYNF FGILDEKQME ELVEFSKKSS QSNQTIWFGH FTTSTIMSPS
PGIRTVMGSA TAYLCGHLHT LGGLMPVLHT RHFTGTLELE VGDWKDNRRY RIFAFDHDLF
SFADVTFDKW PVVLITNPKS LLYSCAKHEP LERLFHSTHI RVLAFSLSPI TSVTVKIDGG
DIGQASHLSG PIFILKWNPR NYSNGTHTIE VFVQDSAGRS RTAHHIFSAQ EDAHLTFDPL
ASFILLTDHY IVARVLFVLI VLIQLTTLIT FRYLAYPELK EPLGFANMTT FSLHILSKIN
ISYYSVLLLT LYTVLGPWFV GEIIDGKLGC CFSFGIFVDG HFLQGGLTFI NGIIQLVFFN
IPLMAYVCWS LLHRCFGHSF RSHLHQGKYW KIIPVYLLIL LLYIWQVYSC YFLHVTYGSL
AFTFSPLRTW LTLLTPVLIY RVWTLNSTEL GIFMVQLKSH LSS
