TMM68_HUMAN
ID TMM68_HUMAN Reviewed; 324 AA.
AC Q96MH6; Q658X6; Q8WUD2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Transmembrane protein 68;
GN Name=TMEM68;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-257 (ISOFORM 1).
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96MH6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96MH6-2; Sequence=VSP_021246;
CC Name=3;
CC IsoId=Q96MH6-3; Sequence=VSP_021244, VSP_021245;
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DR EMBL; AK056932; BAB71312.1; -; mRNA.
DR EMBL; BC020835; AAH20835.1; -; mRNA.
DR EMBL; BC071636; AAH71636.1; -; mRNA.
DR EMBL; AL832935; CAH56335.1; -; mRNA.
DR CCDS; CCDS6161.1; -. [Q96MH6-2]
DR CCDS; CCDS75741.1; -. [Q96MH6-3]
DR CCDS; CCDS75742.1; -. [Q96MH6-1]
DR RefSeq; NP_001273586.1; NM_001286657.1. [Q96MH6-1]
DR RefSeq; NP_001273589.1; NM_001286660.1. [Q96MH6-3]
DR RefSeq; NP_689630.1; NM_152417.2. [Q96MH6-2]
DR RefSeq; XP_005251207.1; XM_005251150.1.
DR RefSeq; XP_011515756.1; XM_011517454.1.
DR AlphaFoldDB; Q96MH6; -.
DR SMR; Q96MH6; -.
DR BioGRID; 126482; 41.
DR IntAct; Q96MH6; 9.
DR STRING; 9606.ENSP00000395204; -.
DR iPTMnet; Q96MH6; -.
DR PhosphoSitePlus; Q96MH6; -.
DR BioMuta; TMEM68; -.
DR DMDM; 118574371; -.
DR EPD; Q96MH6; -.
DR jPOST; Q96MH6; -.
DR MassIVE; Q96MH6; -.
DR MaxQB; Q96MH6; -.
DR PaxDb; Q96MH6; -.
DR PeptideAtlas; Q96MH6; -.
DR PRIDE; Q96MH6; -.
DR ProteomicsDB; 77357; -. [Q96MH6-1]
DR ProteomicsDB; 77358; -. [Q96MH6-2]
DR ProteomicsDB; 77359; -. [Q96MH6-3]
DR Antibodypedia; 11708; 58 antibodies from 16 providers.
DR DNASU; 137695; -.
DR Ensembl; ENST00000334667.6; ENSP00000335416.2; ENSG00000167904.16. [Q96MH6-2]
DR Ensembl; ENST00000434581.7; ENSP00000395204.2; ENSG00000167904.16. [Q96MH6-1]
DR Ensembl; ENST00000521229.5; ENSP00000429210.1; ENSG00000167904.16. [Q96MH6-3]
DR Ensembl; ENST00000522576.5; ENSP00000431047.1; ENSG00000167904.16. [Q96MH6-3]
DR Ensembl; ENST00000617782.4; ENSP00000478242.1; ENSG00000167904.16. [Q96MH6-1]
DR GeneID; 137695; -.
DR KEGG; hsa:137695; -.
DR MANE-Select; ENST00000434581.7; ENSP00000395204.2; NM_001286657.2; NP_001273586.1.
DR UCSC; uc003xsg.2; human. [Q96MH6-1]
DR CTD; 137695; -.
DR GeneCards; TMEM68; -.
DR HGNC; HGNC:26510; TMEM68.
DR HPA; ENSG00000167904; Low tissue specificity.
DR neXtProt; NX_Q96MH6; -.
DR OpenTargets; ENSG00000167904; -.
DR PharmGKB; PA142670781; -.
DR VEuPathDB; HostDB:ENSG00000167904; -.
DR eggNOG; KOG4321; Eukaryota.
DR GeneTree; ENSGT00390000011782; -.
DR HOGENOM; CLU_056812_1_0_1; -.
DR InParanoid; Q96MH6; -.
DR OMA; SDEMYTI; -.
DR OrthoDB; 1558547at2759; -.
DR PhylomeDB; Q96MH6; -.
DR TreeFam; TF312828; -.
DR PathwayCommons; Q96MH6; -.
DR SignaLink; Q96MH6; -.
DR BioGRID-ORCS; 137695; 16 hits in 1080 CRISPR screens.
DR ChiTaRS; TMEM68; human.
DR GenomeRNAi; 137695; -.
DR Pharos; Q96MH6; Tdark.
DR PRO; PR:Q96MH6; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96MH6; protein.
DR Bgee; ENSG00000167904; Expressed in right uterine tube and 168 other tissues.
DR ExpressionAtlas; Q96MH6; baseline and differential.
DR Genevisible; Q96MH6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR Pfam; PF01553; Acyltransferase; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..324
FT /note="Transmembrane protein 68"
FT /id="PRO_0000254592"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 110..135
FT /note="YEVHGMEKIPEDGPALIIFYHGAIPI -> KQGYFHLCVAIHVCCIGTVLPF
FT HFID (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021244"
FT VAR_SEQ 136..324
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021245"
FT VAR_SEQ 230..296
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021246"
SQ SEQUENCE 324 AA; 37425 MW; 8A251314E727CE2E CRC64;
MIDKNQTCGV GQDSVPYMIC LIHILEEWFG VEQLEDYLNF ANYLLWVFTP LILLILPYFT
IFLLYLTIIF LHIYKRKNVL KEAYSHNLWD GARKTVATLW DGHAAVWHGY EVHGMEKIPE
DGPALIIFYH GAIPIDFYYF MAKIFIHKGR TCRVVADHFV FKIPGFSLLL DVFCALHGPR
EKCVEILRSG HLLAISPGGV REALISDETY NIVWGHRRGF AQVAIDAKVP IIPMFTQNIR
EGFRSLGGTR LFRWLYEKFR YPFAPMYGGF PVKLRTYLGD PIPYDPQITA EELAEKTKNA
VQALIDKHQR IPGNIMSALL ERFH
