ID   BTBD9_RAT               Reviewed;         612 AA.
AC   Q5PQR3;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=BTB/POZ domain-containing protein 9;
GN   Name=Btbd9;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=22658601; DOI=10.1016/j.cub.2012.04.027;
RA   Freeman A., Pranski E., Miller R.D., Radmard S., Bernhard D., Jinnah H.A.,
RA   Betarbet R., Rye D.B., Sanyal S.;
RT   "Sleep fragmentation and motor restlessness in a Drosophila model of
RT   Restless Legs Syndrome.";
RL   Curr. Biol. 22:1142-1148(2012).
CC   -!- TISSUE SPECIFICITY: Detected throughout the gray matter of the spinal
CC       cord including the motor neurons (at protein level). In the brain,
CC       detected in the neurons of the hippocampus and in the Purkinje cells of
CC       the cerebellum (at protein level). Also detected in the terospenial
CC       cortex, bed nucleus of the stria terminalis (BST) and the ventrolateral
CC       thalamus (VL) (at protein level). {ECO:0000269|PubMed:22658601}.
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DR   EMBL; BC087068; AAH87068.1; -; mRNA.
DR   RefSeq; NP_001013091.1; NM_001013073.1.
DR   RefSeq; XP_006256247.1; XM_006256185.3.
DR   AlphaFoldDB; Q5PQR3; -.
DR   SMR; Q5PQR3; -.
DR   STRING; 10116.ENSRNOP00000000649; -.
DR   PaxDb; Q5PQR3; -.
DR   Ensembl; ENSRNOT00000000649; ENSRNOP00000000649; ENSRNOG00000000540.
DR   GeneID; 294318; -.
DR   KEGG; rno:294318; -.
DR   CTD; 114781; -.
DR   RGD; 1306975; Btbd9.
DR   eggNOG; KOG4350; Eukaryota.
DR   GeneTree; ENSGT00940000158298; -.
DR   HOGENOM; CLU_004253_0_2_1; -.
DR   InParanoid; Q5PQR3; -.
DR   OMA; YFCRSWQ; -.
DR   OrthoDB; 607923at2759; -.
DR   PhylomeDB; Q5PQR3; -.
DR   PRO; PR:Q5PQR3; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000540; Expressed in testis and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR   GO; GO:0048512; P:circadian behavior; ISO:RGD.
DR   GO; GO:0042748; P:circadian sleep/wake cycle, non-REM sleep; ISO:RGD.
DR   GO; GO:0007616; P:long-term memory; ISO:RGD.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0060586; P:multicellular organismal iron ion homeostasis; ISO:RGD.
DR   GO; GO:1900242; P:regulation of synaptic vesicle endocytosis; ISO:RGD.
DR   GO; GO:0050951; P:sensory perception of temperature stimulus; ISO:RGD.
DR   GO; GO:0042428; P:serotonin metabolic process; ISO:RGD.
DR   CDD; cd14822; BACK_BTBD9; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR034091; BTBD9_BACK-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..612
FT                   /note="BTB/POZ domain-containing protein 9"
FT                   /id="PRO_0000356175"
FT   DOMAIN          36..104
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          142..240
FT                   /note="BACK"
FT   REGION          559..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..588
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   612 AA;  69158 MW;  668A012D97B3B434 CRC64;
     MSNSHPLRPF TAVGEIDHVH ILSEHIGALL IGEEYGDVTF VVEKKRFPAH RVILAARCQY
     FRALLYGGMR ESQPEAEIPL QDTTAEAFTM LLRYIYTGRA TLTDEKEEVL LDFLSLAHKY
     GFPELEDSTS EYLCTILNIQ NVCMTFDVAS LYSLPKLTCM CCMFMDRNAQ EVLASDGFLS
     LSKTALLNIV LRDSFAAPEK DIFLALLNWC KHNAKENHAE IMQAVRLPLM SLTELLNVVR
     PSGLLSPDAI LDAIKVRSES RDMDLNYRGM LIPEENIATM KYGAQVVKGE LKSALLDGDT
     QNYDLDHGFS RHPIDDDCRS GIEIKLGQPS IINHIRLLLW DRDSRSYSYF IEVSMDELDW
     IRVIDHSHYL CRSWQKLYFP ARVCRYIRIV GTHNTVNKIF HIVAFECMFT NKAFTLEKGL
     IAPMENVATI ADCASVIEGV SRSRNALLNG DTKNYDWDSG YTCHQLGSGA IVVQLAQPYM
     IGSIRLLLWD CDDRSYSYYV EVSTNQQQWT MVADRTKVSC KSWQSVTFER QPASFIRIVG
     THNTANEVFH CVHFECPEQQ STQKEDSSEE PGTGDLSTPS QQLDPHAPRA PSASSLPPSP
     GPNLHSPNQQ NQ