TMM68_MOUSE
ID TMM68_MOUSE Reviewed; 329 AA.
AC Q9D850; Q3UGT4; Q8BTV3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transmembrane protein 68;
GN Name=Tmem68;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Cerebellum, Head, Lung, Mammary gland, Small intestine, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D850-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D850-2; Sequence=VSP_021247, VSP_021248;
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DR EMBL; AK008493; BAB25698.1; -; mRNA.
DR EMBL; AK048210; BAC33273.1; -; mRNA.
DR EMBL; AK084881; BAC39301.1; -; mRNA.
DR EMBL; AK088600; BAC40445.1; -; mRNA.
DR EMBL; AK147765; BAE28123.1; -; mRNA.
DR EMBL; AK162563; BAE36969.1; -; mRNA.
DR EMBL; AK165916; BAE38459.1; -; mRNA.
DR EMBL; AK166237; BAE38652.1; -; mRNA.
DR EMBL; BC016240; AAH16240.1; -; mRNA.
DR CCDS; CCDS17937.1; -. [Q9D850-1]
DR RefSeq; NP_082373.1; NM_028097.3. [Q9D850-1]
DR AlphaFoldDB; Q9D850; -.
DR SMR; Q9D850; -.
DR STRING; 10090.ENSMUSP00000029891; -.
DR PhosphoSitePlus; Q9D850; -.
DR SwissPalm; Q9D850; -.
DR EPD; Q9D850; -.
DR MaxQB; Q9D850; -.
DR PaxDb; Q9D850; -.
DR PeptideAtlas; Q9D850; -.
DR PRIDE; Q9D850; -.
DR ProteomicsDB; 259587; -. [Q9D850-1]
DR ProteomicsDB; 259588; -. [Q9D850-2]
DR Antibodypedia; 11708; 58 antibodies from 16 providers.
DR DNASU; 72098; -.
DR Ensembl; ENSMUST00000029891; ENSMUSP00000029891; ENSMUSG00000028232. [Q9D850-1]
DR Ensembl; ENSMUST00000154922; ENSMUSP00000123591; ENSMUSG00000028232. [Q9D850-2]
DR GeneID; 72098; -.
DR KEGG; mmu:72098; -.
DR UCSC; uc008rwh.1; mouse. [Q9D850-1]
DR CTD; 137695; -.
DR MGI; MGI:1919348; Tmem68.
DR VEuPathDB; HostDB:ENSMUSG00000028232; -.
DR eggNOG; KOG4321; Eukaryota.
DR GeneTree; ENSGT00390000011782; -.
DR HOGENOM; CLU_136529_0_0_1; -.
DR InParanoid; Q9D850; -.
DR OMA; SDEMYTI; -.
DR OrthoDB; 1558547at2759; -.
DR PhylomeDB; Q9D850; -.
DR TreeFam; TF312828; -.
DR BioGRID-ORCS; 72098; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q9D850; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D850; protein.
DR Bgee; ENSMUSG00000028232; Expressed in metanephric cortical collecting duct and 257 other tissues.
DR ExpressionAtlas; Q9D850; baseline and differential.
DR Genevisible; Q9D850; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR Pfam; PF01553; Acyltransferase; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..329
FT /note="Transmembrane protein 68"
FT /id="PRO_0000254593"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 164..170
FT /note="GFSLLLD -> VETSQES (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021247"
FT VAR_SEQ 171..329
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021248"
FT CONFLICT 24
FT /note="V -> M (in Ref. 1; BAE28123)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 37810 MW; 764A967BED835758 CRC64;
MIDNNQTCAA GQDSVPYVTC MIYVLEEWLG VEQLEDYLNF ANHLLWVFTP LILLILPYFT
IFLLYLTIIF LHIYKRKNVL KEAYSHNLWD GARKTVATLW DGHAAVWHGY EVHGMEKIPE
GAALIIFYHG AIPIDFYYFM AKIFIQKGRT CRVVADHFVF KIPGFSLLLD VFCALHGPRE
KCVEILRSGH LLAISPGGVR EALLSDETYN IIWGNRKGFA QVAIDAKVPI IPMFTQNIRE
GFRSLGGTRL FKWLYEKFRY PFAPMYGGFP VKLRTFLGDP IPYDPKVTAE ELAEKTKNAV
QALIDKHQRI PGNIRSALLD RFHKEQKAH
