TMM69_MOUSE
ID TMM69_MOUSE Reviewed; 245 AA.
AC Q3KQJ0; A2ACZ7; Q8C9K2;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Transmembrane protein 69;
GN Name=Tmem69;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31112.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AK041960; BAC31112.1; ALT_SEQ; mRNA.
DR EMBL; AL669953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC106178; AAI06179.1; -; mRNA.
DR CCDS; CCDS51277.1; -.
DR RefSeq; NP_808338.2; NM_177670.4.
DR RefSeq; XP_006503070.1; XM_006503007.3.
DR AlphaFoldDB; Q3KQJ0; -.
DR STRING; 10090.ENSMUSP00000065821; -.
DR PhosphoSitePlus; Q3KQJ0; -.
DR MaxQB; Q3KQJ0; -.
DR PaxDb; Q3KQJ0; -.
DR PRIDE; Q3KQJ0; -.
DR ProteomicsDB; 259039; -.
DR Antibodypedia; 32710; 28 antibodies from 16 providers.
DR Ensembl; ENSMUST00000069674; ENSMUSP00000065821; ENSMUSG00000055900.
DR Ensembl; ENSMUST00000106478; ENSMUSP00000102087; ENSMUSG00000055900.
DR GeneID; 230657; -.
DR KEGG; mmu:230657; -.
DR UCSC; uc012djj.1; mouse.
DR CTD; 51249; -.
DR MGI; MGI:3045357; Tmem69.
DR VEuPathDB; HostDB:ENSMUSG00000055900; -.
DR eggNOG; ENOG502RYSE; Eukaryota.
DR GeneTree; ENSGT00390000015318; -.
DR HOGENOM; CLU_095371_0_0_1; -.
DR InParanoid; Q3KQJ0; -.
DR OMA; PCSFKKQ; -.
DR OrthoDB; 1516042at2759; -.
DR PhylomeDB; Q3KQJ0; -.
DR TreeFam; TF336126; -.
DR BioGRID-ORCS; 230657; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q3KQJ0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q3KQJ0; protein.
DR Bgee; ENSMUSG00000055900; Expressed in manus and 221 other tissues.
DR Genevisible; Q3KQJ0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR021836; DUF3429.
DR PANTHER; PTHR15887; PTHR15887; 1.
DR Pfam; PF11911; DUF3429; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..245
FT /note="Transmembrane protein 69"
FT /id="PRO_0000282851"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 27
FT /note="G -> S (in Ref. 3; AAI06179)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 245 AA; 27313 MW; CDA54A127FCA97F7 CRC64;
MLHFIQKVSG ASSKMLKNPF TVRLGAGRID ILSLKTCLLQ NFSSLPPRTW LSPSFQVCMR
KIQCYHVSPC NFKKQKAVLP PKKRSTITYL LDSPKPALYI TLAGLIPFTA PPLLMVITKS
YIPVLAFTQM AYGAGFLAFL GGIRWGFVLP ESSPAKPDYI NLASSMSPIL FSWAAILFSE
RLNEAIVTLI IGLGIALHNE LFLLPHYPNW FKALRIVSTL VAFISFVVTL ILENIYPEKG
PKRPD
