ID   TMM70_CHICK             Reviewed;         246 AA.
AC   Q5ZLJ4;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Transmembrane protein 70, mitochondrial {ECO:0000250|UniProtKB:Q9BUB7};
DE   Flags: Precursor;
GN   Name=TMEM70 {ECO:0000250|UniProtKB:Q9BUB7}; ORFNames=RCJMB04_5o22;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Scaffold protein that participates in the c-ring assembly of
CC       mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by
CC       facilitating the membrane insertion and oligomer formation of the
CC       subunit c/ATP5MC1. Therefore, participates in the early stage of
CC       mitochondrial ATP synthase biogenesis and also protects subunit
CC       c/ATP5MC1 against intramitochondrial proteolysis.
CC       {ECO:0000250|UniProtKB:Q9BUB7}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q9BUB7}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9BUB7}. Note=Mostly located within the inner
CC       cristae membrane. {ECO:0000250|UniProtKB:Q9BUB7}.
CC   -!- SIMILARITY: Belongs to the TMEM70 family. {ECO:0000305}.
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DR   EMBL; AJ719740; CAG31399.1; -; mRNA.
DR   RefSeq; NP_001012866.1; NM_001012848.1.
DR   AlphaFoldDB; Q5ZLJ4; -.
DR   STRING; 9031.ENSGALP00000030240; -.
DR   PaxDb; Q5ZLJ4; -.
DR   GeneID; 420188; -.
DR   KEGG; gga:420188; -.
DR   CTD; 54968; -.
DR   VEuPathDB; HostDB:geneid_420188; -.
DR   eggNOG; KOG4478; Eukaryota.
DR   InParanoid; Q5ZLJ4; -.
DR   OrthoDB; 1513532at2759; -.
DR   PhylomeDB; Q5ZLJ4; -.
DR   PRO; PR:Q5ZLJ4; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0032592; C:integral component of mitochondrial membrane; ISS:UniProtKB.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0140260; F:mitochondrial proton-transporting ATP synthase complex binding; ISS:UniProtKB.
DR   GO; GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; ISS:UniProtKB.
DR   GO; GO:0051259; P:protein complex oligomerization; ISS:UniProtKB.
DR   InterPro; IPR009724; TMEM70.
DR   InterPro; IPR045325; TMEM70/TMEM186/TMEM223.
DR   PANTHER; PTHR13281; PTHR13281; 1.
DR   Pfam; PF06979; TMEM70; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..79
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           80..246
FT                   /note="Transmembrane protein 70, mitochondrial"
FT                   /id="PRO_0000361547"
FT   TOPO_DOM        80..96
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BUB7"
FT   TRANSMEM        97..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..131
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BUB7"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..246
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BUB7"
SQ   SEQUENCE   246 AA;  27432 MW;  78D0E3A2A468407C CRC64;
     MLLRAAGCWR AAASRPGPVW LRGAEHRGLP LASRRLGLPL PLPLAAGGRR LRSGCGALPE
     VASFQGVAVR SLSTSAPSDH PEHGRLVYKG NLAKAVLGVR FFSYSTSIFN LFMAPYLMLK
     TGIGFDSLFL QAAFYGLIGF FTFVTPVTLH ILTKGYVIRL YYKEEMDTYT AITYNAILAE
     KATVFHQKDV KIPDITKMFT TFYAKTKSML VNPTLFPDPQ DYNRLMGYDK AFCFDFEEEE
     KDGESK