TMM71_HUMAN
ID TMM71_HUMAN Reviewed; 295 AA.
AC Q6P5X7; Q3KRC2; Q8WVZ4; Q96LX9;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transmembrane protein 71;
GN Name=TMEM71;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 105-295 (ISOFORM 1).
RC TISSUE=Lung, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6P5X7-2; Q92520: FAM3C; NbExp=3; IntAct=EBI-12886878, EBI-2876774;
CC Q6P5X7-2; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-12886878, EBI-8652744;
CC Q6P5X7-2; Q15560: TCEA2; NbExp=3; IntAct=EBI-12886878, EBI-710310;
CC Q6P5X7-2; Q9Y320: TMX2; NbExp=5; IntAct=EBI-12886878, EBI-6447886;
CC Q6P5X7-2; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12886878, EBI-11988865;
CC Q6P5X7-2; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-12886878, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6P5X7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P5X7-2; Sequence=VSP_023259;
CC Name=3;
CC IsoId=Q6P5X7-3; Sequence=VSP_023260;
CC -!- SIMILARITY: Belongs to the TMEM71 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK057631; BAB71537.1; -; mRNA.
DR EMBL; AF216667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF228727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF257497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF454949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022053; AAH22053.2; -; mRNA.
DR EMBL; BC062592; AAH62592.1; -; mRNA.
DR EMBL; BC105783; AAI05784.1; -; mRNA.
DR CCDS; CCDS47921.1; -. [Q6P5X7-3]
DR CCDS; CCDS6366.1; -. [Q6P5X7-2]
DR RefSeq; NP_001138625.1; NM_001145153.1. [Q6P5X7-3]
DR RefSeq; NP_653250.2; NM_144649.2. [Q6P5X7-2]
DR AlphaFoldDB; Q6P5X7; -.
DR SMR; Q6P5X7; -.
DR BioGRID; 126487; 19.
DR IntAct; Q6P5X7; 6.
DR STRING; 9606.ENSP00000349296; -.
DR iPTMnet; Q6P5X7; -.
DR PhosphoSitePlus; Q6P5X7; -.
DR BioMuta; TMEM71; -.
DR DMDM; 126253812; -.
DR PeptideAtlas; Q6P5X7; -.
DR PRIDE; Q6P5X7; -.
DR Antibodypedia; 74152; 42 antibodies from 12 providers.
DR DNASU; 137835; -.
DR Ensembl; ENST00000356838.7; ENSP00000349296.3; ENSG00000165071.15. [Q6P5X7-2]
DR Ensembl; ENST00000377901.8; ENSP00000367133.4; ENSG00000165071.15. [Q6P5X7-3]
DR Ensembl; ENST00000677595.1; ENSP00000504388.1; ENSG00000165071.15. [Q6P5X7-1]
DR GeneID; 137835; -.
DR KEGG; hsa:137835; -.
DR MANE-Select; ENST00000677595.1; ENSP00000504388.1; NM_001382403.1; NP_001369332.1.
DR UCSC; uc003ytn.4; human. [Q6P5X7-1]
DR CTD; 137835; -.
DR DisGeNET; 137835; -.
DR GeneCards; TMEM71; -.
DR HGNC; HGNC:26572; TMEM71.
DR HPA; ENSG00000165071; Tissue enhanced (bone marrow, heart muscle).
DR MalaCards; TMEM71; -.
DR neXtProt; NX_Q6P5X7; -.
DR OpenTargets; ENSG00000165071; -.
DR PharmGKB; PA142670784; -.
DR VEuPathDB; HostDB:ENSG00000165071; -.
DR eggNOG; ENOG502RZWR; Eukaryota.
DR GeneTree; ENSGT00390000011144; -.
DR HOGENOM; CLU_084224_0_0_1; -.
DR InParanoid; Q6P5X7; -.
DR OMA; QMVALIM; -.
DR OrthoDB; 1207731at2759; -.
DR PhylomeDB; Q6P5X7; -.
DR TreeFam; TF337383; -.
DR PathwayCommons; Q6P5X7; -.
DR SignaLink; Q6P5X7; -.
DR BioGRID-ORCS; 137835; 10 hits in 1067 CRISPR screens.
DR ChiTaRS; TMEM71; human.
DR GenomeRNAi; 137835; -.
DR Pharos; Q6P5X7; Tdark.
DR PRO; PR:Q6P5X7; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6P5X7; protein.
DR Bgee; ENSG00000165071; Expressed in blood and 127 other tissues.
DR ExpressionAtlas; Q6P5X7; baseline and differential.
DR Genevisible; Q6P5X7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR InterPro; IPR027975; TMEM71.
DR PANTHER; PTHR35255; PTHR35255; 1.
DR Pfam; PF15121; TMEM71; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..295
FT /note="Transmembrane protein 71"
FT /id="PRO_0000278283"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 105..123
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023259"
FT VAR_SEQ 163..225
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023260"
FT CONFLICT 156
FT /note="T -> A (in Ref. 3; AAH22053)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="I -> T (in Ref. 1; BAB71537)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 295 AA; 32983 MW; 0A6E95E154DC5F7E CRC64;
MYRISQLMST PVASSSRLER EYAGELSPTC IFPSFTCDSL DGYHSFECGS IDPLTGSHYT
CRRSPRLLTN GYYIWTEDSF LCDKDGNITL NPSQTSVMYK ENLVRIFRKK KRICHSFSSL
FNLSTSKSWL HGSIFGDINS SPSEDNWLKG TRRLDTDHCN GNADDLDCSS LTDDWESGKM
NAESVITSSS SHIISQPPGG NSHSLSLQSQ LTASERFQEN SSDHSETRLL QEVFFQAILL
AVCLIISACA RWFMGEILAS VFTCSLMITV AYVKSLFLSL ASYFKTTACA RFVKI
