TMM72_HUMAN
ID TMM72_HUMAN Reviewed; 275 AA.
AC A0PK05; A1L181; Q5T740;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Transmembrane protein 72;
DE AltName: Full=Kidney-specific secretory protein of 37 kDa;
GN Name=TMEM72; Synonyms=C10orf127, KSP37;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Higuchi T., Katsuya K., Nakanishi S., Orita T., Kobayashi Y., Munger W.,
RA Sun H.W., Falk R.J., Jennette J.C., Alcorta D.A., Li H., Yamamoto T.,
RA Saito Y., Nakamura M.;
RT "TMEM72, a novel transmembranous protein, expressed in distal and
RT collecting tubules.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A0PK05; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-12878352, EBI-747430;
CC A0PK05; Q9HA82: CERS4; NbExp=3; IntAct=EBI-12878352, EBI-2622997;
CC A0PK05; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12878352, EBI-18304435;
CC A0PK05; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-12878352, EBI-713304;
CC A0PK05; P48165: GJA8; NbExp=3; IntAct=EBI-12878352, EBI-17458373;
CC A0PK05; Q9Y5L5: LENEP; NbExp=3; IntAct=EBI-12878352, EBI-12913546;
CC A0PK05; P11836: MS4A1; NbExp=3; IntAct=EBI-12878352, EBI-2808234;
CC A0PK05; Q3MUY2: PIGY; NbExp=3; IntAct=EBI-12878352, EBI-3920125;
CC A0PK05; Q9BS91: SLC35A5; NbExp=3; IntAct=EBI-12878352, EBI-18915901;
CC A0PK05; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12878352, EBI-10982110;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A0PK05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0PK05-2; Sequence=VSP_031343;
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DR EMBL; AL353801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB235418; BAF97794.1; -; mRNA.
DR EMBL; BC127789; AAI27790.1; -; mRNA.
DR EMBL; BC127790; AAI27791.1; -; mRNA.
DR CCDS; CCDS41504.1; -. [A0PK05-1]
DR CCDS; CCDS86085.1; -. [A0PK05-2]
DR RefSeq; NP_001116848.1; NM_001123376.2. [A0PK05-1]
DR RefSeq; NP_001332855.1; NM_001345926.1. [A0PK05-2]
DR RefSeq; XP_011538371.1; XM_011540069.2. [A0PK05-2]
DR RefSeq; XP_011538373.1; XM_011540071.2. [A0PK05-2]
DR AlphaFoldDB; A0PK05; -.
DR BioGRID; 568613; 49.
DR IntAct; A0PK05; 10.
DR STRING; 9606.ENSP00000374234; -.
DR iPTMnet; A0PK05; -.
DR PhosphoSitePlus; A0PK05; -.
DR BioMuta; TMEM72; -.
DR MassIVE; A0PK05; -.
DR PaxDb; A0PK05; -.
DR PeptideAtlas; A0PK05; -.
DR PRIDE; A0PK05; -.
DR ProteomicsDB; 78; -. [A0PK05-1]
DR ProteomicsDB; 79; -. [A0PK05-2]
DR Antibodypedia; 50461; 22 antibodies from 11 providers.
DR DNASU; 643236; -.
DR Ensembl; ENST00000389583.5; ENSP00000374234.4; ENSG00000187783.12. [A0PK05-1]
DR Ensembl; ENST00000544540.5; ENSP00000439911.1; ENSG00000187783.12. [A0PK05-2]
DR GeneID; 643236; -.
DR KEGG; hsa:643236; -.
DR MANE-Select; ENST00000389583.5; ENSP00000374234.4; NM_001123376.3; NP_001116848.1.
DR UCSC; uc001jbn.3; human. [A0PK05-1]
DR CTD; 643236; -.
DR DisGeNET; 643236; -.
DR GeneCards; TMEM72; -.
DR HGNC; HGNC:31658; TMEM72.
DR HPA; ENSG00000187783; Group enriched (choroid plexus, kidney).
DR neXtProt; NX_A0PK05; -.
DR OpenTargets; ENSG00000187783; -.
DR PharmGKB; PA164726549; -.
DR VEuPathDB; HostDB:ENSG00000187783; -.
DR eggNOG; ENOG502RXMX; Eukaryota.
DR GeneTree; ENSGT00390000006888; -.
DR HOGENOM; CLU_067357_0_0_1; -.
DR InParanoid; A0PK05; -.
DR OMA; FKCQPGS; -.
DR OrthoDB; 1128211at2759; -.
DR PhylomeDB; A0PK05; -.
DR TreeFam; TF336492; -.
DR PathwayCommons; A0PK05; -.
DR SignaLink; A0PK05; -.
DR BioGRID-ORCS; 643236; 3 hits in 1010 CRISPR screens.
DR GenomeRNAi; 643236; -.
DR Pharos; A0PK05; Tdark.
DR PRO; PR:A0PK05; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; A0PK05; protein.
DR Bgee; ENSG00000187783; Expressed in renal medulla and 80 other tissues.
DR Genevisible; A0PK05; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR032055; TMEM72.
DR PANTHER; PTHR28474; PTHR28474; 1.
DR Pfam; PF16054; TMEM72; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..275
FT /note="Transmembrane protein 72"
FT /id="PRO_0000319055"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 141..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..118
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031343"
SQ SEQUENCE 275 AA; 29891 MW; 37F5996499CA8F65 CRC64;
MQLQVFWTGL EYTCRLLGIT TAAVLIGVGT ETFLQGQFKS LAFYLLFTGA AVSICEGAYF
VAQLLAICFQ CQPGSLADRV REKAHWLGCF QKFLAYLLLS VACFLHPVLV WHVTIPGSML
IITGLAYFLL SKRKKRKAAP EVLASPEQYT DPSSSAVSTT GSGDTEQTYT FHGALKEGPS
SLFIHMKSIL KGTKKPSALQ PPNTLMELSL EPADSLAKKK QVHFEDNLVR IVPSLAEGLD
DGDSEPEETT SDTTPIIPPP QAPLFLSSLT ATGLF
